Inclusion Criteria:

- Physically inactive

- C-reactive protein level at least 2.0 mg/L but less than 10.0 mg/L upon study entry

- Body mass index between 18.5 kg/square meter and 40.0 kg/square meter as measured at
study entry

- Does not smoke

- Total cholesterol at least 240 mg/dl with LDL-C at least 160 mg/dl OR LDL less than
190 mg/dl and Framingham less than 10%

- Triglyceride levels no higher than 300 mg/dl

- Fasting glucose level less than 126

- Systolic blood pressure less than 140 mm Hg and/or diastolic blood pressure less than
90 mm Hg as measured at study entry

- If taking an oral contraceptive, aspirin, ibuprofen, or other anti-inflammatory
medications, must be on a stable dose for 6 months prior to study entry

- If taking a cholesterol medication, including statins, blood pressure medication
(including ace inhibitors), or multi-vitamins, must be on a stable dose for 2 months
prior to study entry

Exclusion Criteria:

- Using a beta blocker, hormone replacement therapy, or corticosteroids (except
inhalers)

- Any rheumatologic, orthopedic, neurological, or autoimmune diseases, or seizure
disorder

- Any significant cardiovascular disease or disorders including, but not limited to,
stent or coronary artery bypass grafting

- Cardiac dysrhythmias including, but not limited to, left bundle branch block, atrial
fibrillation, pacemaker, or automatic implantable cardioverter defibrillator

- Any surgery, broken bones, blood donation, or anaphylactic shock within 6 months of
study entry

- Any sprain or strain, removal of wisdom teeth, or use of antibiotics within 3 months
of study entry

- History of stroke or TIA

- History of cancer within at least 5 years of study entry

- Diabetes or glucose intolerance

- Planning on participating in any other research trials during the next year

- Currently pregnant

- Planning to becoming pregnant during the next year