Inclusion Criteria

Inclusion Criteria

- Voluntary written informed consent before performance of any study-related procedure
not part of normal medical care, with the understanding that consent may be withdrawn
by the subject at any time without prejudice to future medical care.

- Female subject is either post-menopausal or surgically sterilized or willing to use
an acceptable method of birth control (ie, a hormonal contraceptive, intra-uterine
device, diaphragm with spermicide, condom with spermicide, or abstinence) for the
duration of the study.

- age > 18

- Karnofsky performance status > 60%

- Measurable disease on clinical exam or by RECIST criteria

- One prior platinum-based systemic chemotherapy regimen for advanced disease is
allowed but not required. Chemotherapy administered as a radiosensitizer in
conjunction with primary radiotherapy is not considered a systemic chemotherapy
regimen and is also allowed. Patients eligible for a higher priority study will be
excluded.

- Life expectancy > 6 weeks

- Peripheral neuropathy ≤ Grade 2 by CTC 3.0 criteria

- Women of child-bearing potential must have a negative pregnancy test

- Adequate hematopoietic function defined as: ANC ≥ 1500/mm3; Platelets ≥ 100,000/mm3;
Hemoglobin ≥ 8 g/dL.

- Adequate renal and hepatic function defined as: Bilirubin ≤ 1.5 times upper limit of
normal (ULN); SGOT ≤ 2.5 times ULN; Alkaline phosphatase ≤ 2.5 times ULN; Creatinine
≤ 2 times ULN.

Exclusion Criteria

- Patient has hypersensitivity to bortezomib, boron or mannitol.

- Female subject is pregnant or breast-feeding.

- Patient has received other investigational drugs with 14 days before enrollment

- Serious medical or psychiatric illness likely to interfere with participation in this
clinical study.

- Prior treatment with CAMPTOSAR or VELCADE

- More than one prior treatment for metastatic disease.

- Concurrent uncontrolled illness

- Ongoing or active infection

- History or active secondary cancer within the last 5 years, except for superficial
basal cell skin cancers

- Psychiatric illness or social situation that would preclude study compliance.