Inclusion Criteria:

- Males and females of at least 18 years of age with stage IV or unresectable stage III
non-ocular melanoma who may have received 0 to 2 prior regimens for metastatic
disease with a biological therapy or immunotherapy (e.g., IL-2 or interferon-alfa).

- Measurable disease according to Response Criteria for Solid Tumors (RECIST).

- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 1.

- Estimated survival is greater or equal to 4 months.

- Negative pregnancy test (women of childbearing potential only).

- Pretreatment laboratory levels that meet specific criteria.

- Signed informed consent, including permission to use protected health information.

Exclusion Criteria:

- Prior treatment with M200 or a5b1 inhibitors and murine or chimeric monoclonal
antibodies.

- Prior treatment with DTIC, temozolomide, or other chemotherapeutic regimens.

- Known sensitivity to murine proteins or chimeric antibodies or other components of
the product.

- Use of any investigational drug within 4 weeks prior to screening or 5 half-lives of
the prior investigational drug (whichever is longer).

- Systemic biologic, immunotherapy, and/or radiation therapy within 4 weeks of the
first dose of M200.

- Documented central nervous system (CNS) tumor or CNS metastasis.

- History of thromboembolic events and bleeding disorders within the past year.

- Medical conditions that may be exacerbated by bleeding.