Selective Venous Catheterization for the Localization of Phosphaturic Mesenchymal Tumors
Phosphaturic mesenchymal tumors elaborate phosphate lowering factors (phosphatonins) which
lead to tumor induced osteomalacia/osteogenic osteomalacia (TIO/OOM). Patients with TIO/OOM
suffer years of significant morbidity and debilitation unless their tumors, which are
notoriously difficult to locate, are removed.
Selective venous catheterization has been used to localize hormonally active neoplasms by
demonstrating a gradient in the concentration of the hormone of interest between the vessel
immediately draining the tumor site and the peripheral circulation. The primary objective
of this protocol is to evaluate the utility of combining selective venous catheterization
with biochemical assays that identify phosphatonins in the serum as a way to identify
phosphatonin gradients and thereby localize phosphaturic tumors.
Our study population will consist of TIO/OOM patients with non-localized phosphaturic tumors
as well as five patients whose lesions have been identified with some certainty by
conventional imaging techniques. These individuals will undergo selective venous
catheterization during which blood samples will be obtained and processed for the presence
of phosphatonins. The primary endpoint will be met if a gradient indicating a possible
tumor is found, focused clinical imaging in the appropriate anatomical sub-region identifies
a lesion, and the lesion is confirmed to be a phosphaturic mesenchymal tumor upon surgical
removal.
Observational
N/A
United States: Federal Government
050050
NCT00099762
December 2004
Name | Location |
---|---|
National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda, Maryland 20892 |