Dietary Energy Restriction and Metabolic Aging in Humans
25 Years
50 Years
Both
Aging
Trial Information
Dietary Energy Restriction and Metabolic Aging in Humans
Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts
University are enrolling overweight men and women aged 20-42 in a 1-year study to develop an
effective calorie restricted regimen that minimizes hunger and prevents weight regain. The
study also examines the effects of weight loss on body composition, metabolism and aging.
Two different diets containing usual foods and a healthy balance of nutrients will be tested
at 2 levels of caloric restriction, 10% and 30% (in other words, 90% or 70% of what one
would normally eat). Weight loss is expected for most volunteers participating in this
study, but cannot be guaranteed.
Inclusion Criteria
Inclusion Criteria
- Healthy men and women
- Body mass index (BMI) = 25-30
- Slightly overweight, < 275 lbs
- Women 25-45, pre-menopause
- Men 25-50
- Not traveling often or planning to move
Exclusions:
- Cardiovascular disease or blood pressure greater than 160/90
- Diabetes
- Major psychiatric disorders
- Eating disorders
- Post obese; previous BMI > 32
- Weight change of more than ten pounds in the past 90 days
- Over 275 pounds
- Smoking
- Regular exercise, more than twice per week
- Current prescription drug use, except oral contraceptives
- Alcoholism or substance abuse
- Pregnant or lactating (breast feeding), planning to become pregnant, or not regularly
using contraception
- Abnormal electrocardiogram (EKG)
- Local resident for less than one year
- Occupations requiring full alertness and motor skills, with no allowance for a chance
of postural dizziness (airline pilots, etc.)
- Injuries by any metallic object that is still present in the body
- Braces, non-removable dentures, or non-removable bridgework
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention
Principal Investigator
Susan B. Roberts, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Jean Mayer USDA HNRCA at Tufts University
Authority:
United States: Federal Government
Study ID:
AG0006
NCT ID:
NCT00099099
Start Date:
March 2002
Completion Date:
December 2004
Related Keywords:
- Aging
- Longevity
- Calorie restriction
- Physical activity
- Weight loss
Name | Location |
|---|---|
| Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University | Boston, Massachusetts 02111-1524 |
