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Dietary Energy Restriction and Metabolic Aging in Humans


Phase 1
25 Years
50 Years
Not Enrolling
Both
Aging

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Trial Information

Dietary Energy Restriction and Metabolic Aging in Humans


Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts
University are enrolling overweight men and women aged 20-42 in a 1-year study to develop an
effective calorie restricted regimen that minimizes hunger and prevents weight regain. The
study also examines the effects of weight loss on body composition, metabolism and aging.
Two different diets containing usual foods and a healthy balance of nutrients will be tested
at 2 levels of caloric restriction, 10% and 30% (in other words, 90% or 70% of what one
would normally eat). Weight loss is expected for most volunteers participating in this
study, but cannot be guaranteed.

Inclusion Criteria


Inclusion Criteria

- Healthy men and women

- Body mass index (BMI) = 25-30

- Slightly overweight, < 275 lbs

- Women 25-45, pre-menopause

- Men 25-50

- Not traveling often or planning to move

Exclusions:

- Cardiovascular disease or blood pressure greater than 160/90

- Diabetes

- Major psychiatric disorders

- Eating disorders

- Post obese; previous BMI > 32

- Weight change of more than ten pounds in the past 90 days

- Over 275 pounds

- Smoking

- Regular exercise, more than twice per week

- Current prescription drug use, except oral contraceptives

- Alcoholism or substance abuse

- Pregnant or lactating (breast feeding), planning to become pregnant, or not regularly
using contraception

- Abnormal electrocardiogram (EKG)

- Local resident for less than one year

- Occupations requiring full alertness and motor skills, with no allowance for a chance
of postural dizziness (airline pilots, etc.)

- Injuries by any metallic object that is still present in the body

- Braces, non-removable dentures, or non-removable bridgework

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention

Principal Investigator

Susan B. Roberts, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Jean Mayer USDA HNRCA at Tufts University

Authority:

United States: Federal Government

Study ID:

AG0006

NCT ID:

NCT00099099

Start Date:

March 2002

Completion Date:

December 2004

Related Keywords:

  • Aging
  • Longevity
  • Calorie restriction
  • Physical activity
  • Weight loss

Name

Location

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts UniversityBoston, Massachusetts  02111-1524