A Long-Term Follow-Up Study Evaluating the Efficacy and Delayed Toxicities of Radioiodinated Tositumomab (Anti-CD20 Antibody) Followed by Autologous Transplantation for Relapsed or Refractory Non-Hodgkin's Lymphoma
- Determine the progression-free survival and overall survival of patients with relapsed
or refractory B-cell non-Hodgkin's lymphoma previously treated with iodine I^131
tositumomab followed by autologous bone marrow or stem cell transplantation on FHCRC
protocols 296, 521, 792, or 915.
- Determine the long-term toxic effects of this regimen in these patients.
- Determine the quality of life of patients treated with this regimen.
OUTLINE: This is a long-term, follow-up study.
Patients undergo testing for human anti-mouse antibody at 1, 3 and 12 months. Patients
undergo physical examinations, blood tests, and immune system assessments every 3 months for
1 year and then annually thereafter. Thyroid, pulmonary, and cardiac function are assessed
at 1 year and then annually as needed. Patients also undergo CT scans and bone marrow biopsy
(if clinically indicated) annually for up to 10 years.
Quality of life is assessed annually.
PROJECTED ACCRUAL: A total of 47 patients will be accrued for this study.
Observational Model: Cohort, Time Perspective: Prospective
Progression-free and overall survival of patients on phase I and II trials by Kaplan Meier survival analyses annually
Annual throughout survival
Oliver W. Press, MD, PhD
Fred Hutchinson Cancer Research Center
United States: Federal Government
|Fred Hutchinson Cancer Research Center||Seattle, Washington 98109|