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A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon

Phase 3
18 Years
Open (Enrolling)
Colorectal Cancer

Thank you

Trial Information

A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon



- Compare disease-free survival of patients with resected stage II or III adenocarcinoma
of the colon treated with adjuvant chemotherapy comprising fluorouracil, leucovorin
calcium, and oxaliplatin with vs without bevacizumab.


- Compare overall survival of patients treated with these regimens.


- Determine the persistence of proteinuria after completion of bevacizumab in patients
treated with bevacizumab.

- Correlate the development of proteinuria with clinical sequelae in patients treated
with bevacizumab.

- Determine risk factors for development of proteinuria in patients treated with

- Determine the effect of discontinuing bevacizumab on hypertension in these patients.

- Determine the incidence of delayed vascular events (e.g., myocardial infarction,
Central Nervous System (CNS) ischemia, and thrombosis) in patients treated with
chemotherapy in combination with bevacizumab.

- Determine the effect of this drug on ovarian function in premenopausal women.

- Determine the incidence rate of immunogenicity and serum levels of bevacizumab in these

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
participating center and number of positive lymph nodes (0 vs 1-3 vs > 3). Patients are
randomized to 1 of 2 treatment arms.

- Arm I: Patients receive adjuvant chemotherapy comprising concurrent oxaliplatin and
leucovorin calcium IV over 2 hours on day 1. Patients also receive adjuvant
fluorouracil IV over 2-4 minutes on day 1 followed by fluorouracil IV continuously over
46 hours on days 1 and 2. Treatment repeats every 14 days for 12 courses in the absence
of disease progression or unacceptable toxicity.

- Arm II: Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also
receive adjuvant oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Treatment repeats every 14 days for 12 courses in the absence of disease progression or
unacceptable toxicity. After completion of adjuvant chemotherapy, patients continue to
receive bevacizumab alone every 14 days for 6 months in the absence of disease
progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 2,632 patients (1,316 per treatment arm) will be accrued for
this study within 2.5 years.

Inclusion Criteria


- Histologically confirmed adenocarcinoma of the colon, meeting 1 of the following
stage criteria:

- Stage II disease (T3 or 4, N0, M0)

- Stage III disease (any T, N1 or 2, M0)

- No rectal tumors

- Distal extent of tumor ≥ 12 cm from the anal verge by endoscopy or surgical

- T4 tumors involving an adjacent structure (e.g., bladder, small intestine, or ovary)
by direct extension from the primary tumor are eligible provided the following
criteria are met:

- All or a portion of the adjacent structure was removed en bloc with the primary

- All grossly visible tumor was completely resected (i.e., curative resection) in
the opinion of the surgeon

- Margins of the resected specimen not involved with malignant cells by pathology

- Not planning local radiotherapy

- En bloc complete gross resection of tumor by open laparotomy or
laparoscopically-assisted colectomy within the past 29-50 days

- Two-stage surgical procedure allowed (i.e., decompressive colostomy followed by
definitive surgical resection)

- Patients with > 1 synchronous primary colon tumor are eligible

- Disease staging based on more advanced primary tumor

- No isolated, distant, or non-contiguous intra-abdominal metastases, even if resected



- 18 and over

Performance status

- Eastern Cooperative Oncology Group (ECOG) 0-1

Life expectancy

- At least 5 years


- Absolute granulocyte count ≥ 1,500/mm^3 (unless it represents an ethnic or racial
variation of normal)

- Postoperative platelet count ≥ 100,000/mm^3

- No significant bleeding unrelated to the primary colon tumor within the past 6 months


- Bilirubin ≤ upper limit of normal (ULN) (unless due to slow conjugation of bilirubin
caused by Gilbert's disease or a similar syndrome)

- Alkaline phosphatase < 2.5 times ULN

- Aspartate Aminotransferase (AST) < 1.5 times ULN

- If AST > normal, serologic testing for hepatitis B and C is required and the
results must be negative

- No Prothrombin Time and International Normalized Ratio (PT/INR) > 1.5 unless patient
is on full-dose anticoagulants AND the following criteria are met:

- INR 2-3 on a stable dose of warfarin

- No active bleeding

- No pathological condition associated with a high risk of bleeding

- No hepatic disease that would preclude study participation

- No history of viral hepatitis or other chronic liver disease


- Serum creatinine ≤ 1.5 times ULN

- Urine protein/creatinine ratio < 1.0 OR

- < 1 g of protein on 24-hour urine collection

- No renal disease that would preclude study participation


- No uncontrolled blood pressure, defined as > 150/90 mm Hg

- No cardiovascular disease that would preclude study participation, including any of
the following:

- New York Heart Association class III or IV myocardial disease

- Myocardial infarction within the past 12 months

- Unstable angina within the past 12 months

- Symptomatic arrhythmia

- No history of transient ischemic attack or cerebrovascular accident

- No arterial thrombotic event within the past 12 months

- No symptomatic peripheral vascular disease


- No other malignancy within the past 5 years except effectively treated squamous cell
or basal cell skin cancer, melanoma in situ, carcinoma in situ of the cervix, or
carcinoma in situ of the colon or rectum

- Must be at low risk of recurrence from any prior malignancy

- No serious or non-healing wound, skin ulcer, or bone fracture

- No active gastroduodenal ulcer by endoscopy

- No clinically significant peripheral neuropathy (i.e., neurosensory or neuromotor
toxicity ≥ grade 2)

- No significant traumatic injury within the past 4 weeks

- No other nonmalignant systemic disease that would preclude study participation

- No psychiatric or addictive disorder or other condition that would preclude study

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Patients randomized to receive bevacizumab must use effective contraception
during and for 3 months after study treatment


Biologic therapy

- No concurrent prophylactic growth factors

- No concurrent biological response modifiers


- Not specified

Endocrine therapy

- Not specified


- See Disease Characteristics

- No prior radiotherapy for this malignancy

- No concurrent radiotherapy for this malignancy


- See Disease Characteristics

- Recovered from prior surgery

- More than 4 weeks since prior major surgery or open biopsy

- More than 7 days since prior core biopsy or other minor surgery (except placement of
a vascular access device)

- No concurrent or anticipated concurrent major surgery


- No prior systemic therapy for this malignancy

- No concurrent halogenated antiviral agents (e.g., sorivudine)

- No other concurrent investigational drugs

- No other concurrent antineoplastic agents

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free Survival

Outcome Description:

Where events are defined as recurrence, second primary cancer, or death from any cause

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

September 2004

Completion Date:

March 2014

Related Keywords:

  • Colorectal Cancer
  • adenocarcinoma of the colon
  • stage II colon cancer
  • stage III colon cancer
  • Colonic Neoplasms
  • Colorectal Neoplasms



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St. Joseph Mercy Cancer Center at St. Joseph Mercy HospitalAnn Arbor, Michigan  48106-0995
Mecosta County Medical CenterBig Rapids, Michigan  49307
Green Bay Oncology, Limited - Iron MountainIron Mountain, Michigan  49801
Upper Michigan Cancer Center at Marquette General HospitalMarquette, Michigan  49855
Community Cancer Center of MonroeMonroe, Michigan  48162
Mercy Memorial Hospital SystemMonroe, Michigan  48162
MeritCare Clinic - BemidjiBemidji, Minnesota  56601
Virginia Piper Cancer Institute at Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Chippewa County - Montevideo HospitalMontevideo, Minnesota  56265
Hubert H. Humphrey Cancer Center at North Memorial Medical CenterRobbinsdale, Minnesota  55422-2900
Coborn Cancer CenterSaint Cloud, Minnesota  56303
CentraCare Clinic - River CampusSt. Cloud, Minnesota  56303
Park Nicollet Health ServicesSt. Louis Park, Minnesota  55416
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Immanuel Medical CenterOmaha, Nebraska  68122
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Mountainside Hospital Cancer CenterMontclair, New Jersey  07042
Fox Chase Cancer Center at St. Francis Medical CenterTrenton, New Jersey  08629
Iredell Memorial HospitalStatesville, North Carolina  28677
Cancer Care Center at Medcenter One HospitalBismarck, North Dakota  58501
Bismarck Cancer CenterBismarck, North Dakota  58501
St. Alexius Medical CenterBismarck, North Dakota  58502
Mid Dakota Clinic, P. C.Bismarck, North Dakota  58501
MeritCare Medical GroupFargo, North Dakota  58122
Wood County Oncology CenterBowling Green, Ohio  43402
Grandview HospitalDayton, Ohio  45405
David L. Rike Cancer Center at Miami Valley HospitalDayton, Ohio  45409
Good Samaritan HospitalDayton, Ohio  45406
Fremont Memorial HospitalFremont, Ohio  43420
Charles F. Kettering Memorial HospitalKettering, Ohio  45429
Lima Memorial HospitalLima, Ohio  45804
St. Luke's HospitalMaumee, Ohio  43537
Northwest Ohio Oncology CenterMaumee, Ohio  43537
Middletown Regional HospitalMiddletown, Ohio  45044
Toledo Clinic - OregonOregon, Ohio  43616
St. Charles Mercy HospitalOregon, Ohio  43616
North Coast Cancer Care, IncorporatedSandusky, Ohio  44870
Firelands Regional Medical CenterSandusky, Ohio  44870
Mercy Medical CenterSpringfield, Ohio  45504
Mercy Hospital of TiffinTiffin, Ohio  44883
Toledo Clinic, Incorporated - Main ClinicToledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical CenterTroy, Ohio  45373-1300
Fulton County Health CenterWauseon, Ohio  43567
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXenia, Ohio  45385
LaFortune Cancer Center at St. John Medical CenterTulsa, Oklahoma  74104
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer CenterPortland, Oregon  97210
Kaiser Permanente Health Care - PortlandPortland, Oregon  97232
Providence Cancer Center at Providence Portland Medical CenterPortland, Oregon  97213-2967
Providence St. Vincent Medical CenterPortland, Oregon  97225
Legacy Meridian Park HospitalTualatin, Oregon  97062
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
St. Mary Regional Cancer CenterLanghorne, Pennsylvania  19047
Hematology and Oncology AssociatesScranton, Pennsylvania  18510
Lankenau Cancer Center at Lankenau HospitalWynnewood, Pennsylvania  19096
Bon Secours St. Francis Health SystemGreenville, South Carolina  29601
Oncology Services of AberdeenAberdeen, South Dakota  57401
Baptist Regional Cancer Center at Baptist Hospital of East TennesseeKnoxville, Tennessee  37901
UMC Southwest Cancer and Research CenterLubbock, Texas  79415-3364
Dixie Regional Medical Center - East CampusSaint George, Utah  84770
Mountainview MedicalBerlin, Vermont  05602
Danville Regional Medical CenterDanville, Virginia  24541
Southwest Washington Medical Center Cancer CenterVancouver, Washington  98668
North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, Washington  98902
Washington Hematology-Oncology SpecialistsYakima, Washington  98902
Green Bay Oncology, Limited at St. Vincent HospitalGreen Bay, Wisconsin  54301-3526
Holy Family Memorial Medical Center Cancer Care CenterManitowoc, Wisconsin  54221-1450
Welch Cancer Center at Sheridan Memorial HospitalSheridan, Wyoming  82801
Fairbanks Cancer Treatment Center at Fairbanks Memorial HospitalFairbanks, Alaska  99701
Montrose Memorial Hospital Cancer CenterMontrose, Colorado  81401
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
DeCesaris Cancer Institute at Anne Arundel Medical CenterAnnapolis, Maryland  21401
Cascade Cancer Center at Evergreen Hospital Medical CenterKirkland, Washington  98034-3013
Olympic Medical CenterPort Angeles, Washington  98362
Valley Medical CenterRenton, Washington  98055
Creticos Cancer Center at Advocate Illinois Masonic Medical CenterChicago, Illinois  60657
Mercy Cancer Center at Mercy Medical Center - North IowaMason City, Iowa  50401
Hudner Oncology Center at Saint Anne's HospitalFall River, Massachusetts  02721
Cancer Care Center at St. Luke's HospitalDuluth, Minnesota  55805
Regional Cancer Center at Singing River HospitalPascagoula, Mississippi  39581
Saint Luke's HospitalChesterfield, Missouri  63017
Missouri Baptist Cancer CenterSt. Louis, Missouri  63131
Cancer Resource Center - LincolnLincoln, Nebraska  68510
Washoe Cancer Services at Washoe Medical Center - RenoReno, Nevada  89502
Capital Health System Regional Cancer CenterTrenton, New Jersey  08618
Randolph HospitalAsheboro, North Carolina  27203
Moses Cone Regional Cancer Center at Wesley Long Community HospitalGreensboro, North Carolina  27401
Annie Penn Cancer CenterReidsville, North Carolina  27320
Altru Cancer Center at Altru HospitalGrand Forks, North Dakota  58201
Huron Hospital Cancer Care CenterCleveland, Ohio  44112
Euclid HospitalCleveland, Ohio  44119
South Pointe Hospital Cancer Care CenterWarrensville Heights, Ohio  44122
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania HospitalPittsburgh, Pennsylvania  15224-1791
St. Joseph Medical CenterReading, Pennsylvania  19604
All Saints Cancer Center at All Saints HealthcareRacine, Wisconsin  53405
Carl and Dorothy Bennett Cancer Center at Stamford HospitalStamford, Connecticut  06904
Florida Cancer Specialists - Sarasota DowntownSarasota, Florida  34236
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/CandlerSavannah, Georgia  31405
McFarland Clinic, PCAmes, Iowa  50010
Covenant Cancer Treatment CenterWaterloo, Iowa  50702
Cancer Center of Kansas, PA - ChanuteChanute, Kansas  66720
Cancer Center of Kansas, PA - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas, PA - KingmanKingman, Kansas  67068
Cancer Center of Kansas, PA - NewtonNewton, Kansas  67114
Cancer Center of Kansas, PA - ParsonsParsons, Kansas  67357
Cancer Center of Kansas, PA - PrattPratt, Kansas  67124
Cancer Center of Kansas, PA - SalinaSalina, Kansas  67401
Cancer Center of Kansas, PA - WellingtonWellington, Kansas  67152
Cancer Center of Kansas, PA - WichitaWichita, Kansas  67214
Associates in Womens Health, PA - North ReviewWichita, Kansas  67208
Cancer Center of Kansas, PA - Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas, PA - WinfieldWinfield, Kansas  67156
Haematology-Oncology Associates of Ohio and Michigan, PCLambertville, Michigan  48144
St. Joseph Mercy OaklandPontiac, Michigan  48341-2985
Mercy Regional Cancer Center at Mercy HospitalPort Huron, Michigan  48060
Alegant Health Cancer Center at Bergan Mercy Medical CenterOmaha, Nebraska  68124
Flower Hospital Cancer CenterSylvania, Ohio  43560
Cleo Craig Cancer Research ClinicLawton, Oklahoma  73505
Cancer Care Associates - Mercy CampusOklahoma City, Oklahoma  73120
Guthrie Cancer Center at Guthrie Clinic SayreSayre, Pennsylvania  18840
St. Joseph Cancer CenterBellingham, Washington  98225
Community Comprehensive Cancer Center at Camden-Clark Memorial HospitalParkersburg, West Virginia  26102
Oncology Alliance, SC - Milwaukee - EastGlendale, Wisconsin  53212-1038
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311
Medical Consultants, LimitedMilwaukee, Wisconsin  53215
Vince Lombardi Cancer Clinic - SheboyganSheboygan, Wisconsin  53081
Cancer Resource Center at King's Daughters Medical CenterAshland, Kentucky  41101
Methodist Cancer Center at Methodist Hospital - OmahaOmaha, Nebraska  68114
Saint Louis University Cancer CenterSaint Louis, Missouri  63110
Community HospitalMunster, Indiana  46321
Aurora Sinai Medical CenterMilwaukee, Wisconsin  53201-0342
Phoebe Cancer Center at Phoebe Putney Memorial HospitalAlbany, Georgia  31702
Hematology Oncology Associates of Eastern IdahoIdaho Falls, Idaho  83404
Caritas Norwood HospitalNorwood, Massachusetts  02062
Good Samaritan Cancer Center at Good Samaritan HospitalKearney, Nebraska  68848-1990
Elliot Regional Cancer Center at Elliot HospitalManchester, New Hampshire  03103
AtlantiCare Regional Medical CenterPomona, New Jersey  08240
Tucker Center for Cancer Care at Orange Regional Medical CenterMiddletown, New York  10940-4199
Pardee Memorial HospitalHendersonville, North Carolina  28791
Rex Cancer Center at Rex HospitalRaleigh, North Carolina  27607
Rutherford HospitalRutherfordton, North Carolina  28139
Cancer Treatment Center at Good Samaritan HospitalCincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health CenterWarren, Ohio  44484
York Cancer Center at Wellspan HealthYork, Pennsylvania  17403
AnMed Health Cancer CenterAnderson, South Carolina  29621
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Martha Jefferson Hospital Cancer Care CenterCharlottesville, Virginia  22901
Regional Cancer Center at Oconomowoc Memorial HospitalOconomowoc, Wisconsin  53066
MedCentral - Mansfield HospitalMansfield, Ohio  44903
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical CenterLos Angeles, California  90033
St. Vincent's Medical CenterJacksonville, Florida  32203
Sherman HospitalElgin, Illinois  60120-2198
St. Francis HospitalEvanston, Illinois  60202
Center for Cancer Care at Goshen Health SystemGoshen, Indiana  46526
Frederick Memorial Hospital Regional Cancer Therapy CenterFrederick, Maryland  21701
Jordan Hospital Club Cancer CenterPlymouth, Massachusetts  02360
St. John's Regional Medical CenterJoplin, Missouri  64804
Freeman Cancer Institute at Freeman Health SystemJoplin, Missouri  64803-2644
Underwood Memorial HospitalWoodbury, New Jersey  08096
New Mexico Cancer Care AssociatesSanta Fe, New Mexico  87505-7670
Central Pennsylvania Hematology and Medical Oncology Associates, PCLemoyne, Pennsylvania  17043
Huntsville HospitalHuntsville, Alabama  35807
Nalitt Cancer Institute at Staten Island University HospitalStaten Island, New York  10305
California Cancer Care, IncorporatedGreenbrae, California  94904
La Grange Memorial HospitalLa Grange, Illinois  60525
Mid-Illinois Hematology-Oncology Associates at Community Cancer CenterNormal, Illinois  61761
Cedar Valley Medical Specialists, PC - West Ridgeway AvenueWaterloo, Iowa  50702
Arch Medical Services, Incorporated at Center for Cancer Care ResearchSaint Louis, Missouri  63141
Sletten Regional Cancer Institute at Benefis HealthcareGreat Falls, Montana  59405
Lakes Region General HospitalLaconia, New Hampshire  03246
PinnacleHealth Regional Cancer Center at Polyclinic HospitalHarrisburg, Pennsylvania  17105
Cancer Care Institute of Carolina at Aiken Regional Medical CentersAiken, South Carolina  29801
Roper St. Francis Cancer Center at Roper HospitalCharleston, South Carolina  29401
Rockwood Clinic Cancer Treatment CenterSpokane, Washington  99204-2967
Florida Oncology AssociatesOrange Park, Florida  32073
Lipson Cancer and Blood Center at Rochester General HospitalRochester, New York  14621
Veterans Affairs Medical Center - AugustaAugusta, Georgia  30904
Shore Memorial Hospital - Somers PointSomers Point, New Jersey  08244
Marshall University Medical CenterHuntington, West Virginia  25701
Louisville Oncology at Norton Cancer CenterLouisville, Kentucky  40202
Doctors Medical Center - San Pablo CampusSan Pablo, California  94806
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Mercy General HospitalSacramento, California  95819
Iowa Blood and Cancer CareCedar Rapids, Iowa  52402
Caritas St. Elizabeth's Medical CenterBrighton, Massachusetts  02135-2997
Hattiesburg Clinic, PA at Forrest GeneralHattiesburg, Mississippi  39401
United States Air Force Medical Center - Wright-PattersonWright-Patterson AFB, Ohio  45433-5529
Dale and Frances Hughes Cancer Center at Pocono Medical CenterEast Stroudsburg, Pennsylvania  18301
Associates in Hematology-Oncology, PC at Crozer Regional Cancer CenterUpland, Pennsylvania  19013
Watson Clinic, LLCLakeland, Florida  33804-5000
Provena St. Mary's Wasser Regional Cancer Center - KankakeeKankakee, Illinois  60901
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia FieldsOlympia Fields, Illinois  60461
Lovelace Medical CenterAlbuquerque, New Mexico  87108
Minnesota Oncology Hematology, PA at Maplewood Cancer CenterMaplewood, Minnesota  55109
St. Mary's Regional Cancer Center at St. Mary's Medical CenterHuntington, West Virginia  25702
Ocean Medical Center at Meridian HealthBrick, New Jersey  08724
Heartland Oncology & HematologyCouncil Bluffs, Iowa  51503
Christus Schumpert Cancer Treatment CenterShreveport, Louisiana  71101
Mercy Hospital of PortlandPortland, Maine  04101
South Shore HospitalSouth Weymouth, Massachusetts  02190
CaroMont Cancer Center at Gaston Memorial HospitalGastonia, North Carolina  28053
Howard University Cancer Center at Howard University HospitalWashington, District of Columbia  20060
Ottumwa Regional Health Center Cancer CenterOttumwa, Iowa  52501
Northeast Georgia Cancer Care, LLCAthens, Georgia  30607
Hematology Oncology Associates, PCAlbuquerque, New Mexico  87106
Jersey Shore Cancer Center at Jersey Shore University Medical CenterNeptune, New Jersey  07754-0397
Mercy Regional Cancer Center at Mercy Medical CenterRedding, California  96049
NSMC Cancer Center - PeabodyPeabody, Massachusetts  01960
Hematology & Oncology ClinicHattiesburg, Mississippi  39402
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical CenterPlattsburgh, New York  12901
Virginia Cancer Institute - West EndRichmond, Virginia  23230
Mercy Regional Cancer CenterJanesville, Wisconsin  53547
East Alabama Medical CenterOpelika, Alabama  36801-5452
Cancer Care Center at John Muir Health - Concord CampusConcord, California  94524-4110
University of Tennessee Cancer Institute - Medical CenterMemphis, Tennessee  38104
Cancer Center at Providence Alaska Medical CenterAnchorage, Alaska  99519-6604
Camino Medical Group - Treatment CenterMountain View, California  94040
Delnor Community Hospital - GenevaGeneva, Illinois  60134
Methodist Cancer Center at Clarian HealthIndianapolis, Indiana  46202
Holy Cross HospitalSilver Spring, Maryland  20910
Cancer Institute at St. Joseph Medical CenterTowson, Maryland  21204
Exeter Hospital Center for Cancer CareExeter, New Hampshire  03833
New York Oncology Hematology, PC at Albany Regional Cancer CareAlbany, New York  12208
Falck Cancer Center at Arnot Ogden Medical CenterElmira, New York  14905
New York Oncology Hematology, P.C. at Cavell Cancer Treatment ProgramHudson, New York  12534
Riverview Cancer Care Medical Associates, PCRexford, New York  12148
New York Oncology Hematology, P.C. - Ellis OfficeSchenectady, New York  12308
Samaritan Hospital at Northeast HealthTroy, New York  12180
Oncology Hematology Care, Incorporated - Blue AshCincinnati, Ohio  45242
Ephrata Cancer Center at Ephrata Community HospitalEphrata, Pennsylvania  17522
Cancer Center at Riddle Memorial HospitalMedia, Pennsylvania  19063
Frankford Hospital - Torresdale CampusPhiladelphia, Pennsylvania  19114
Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry CountyMartinsville, Virginia  24115
Peninsula Cancer InstituteNewport News, Virginia  23601
Overlake Cancer Center at Overtake Hospital Medical CenterBellevue, Washington  98004
St. Mary Regional Cancer Center at St. Mary Medical CenterWalla Walla, Washington  99362
Richard G. Laube Cancer Center at ACMHKittanning, Pennsylvania  16201
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett HospitalCooperstown, New York  13326
Ida M. and Cecil H. Green Cancer Center at Scripps ClinicLa Jolla, California  92037-1027
Vince Lombardi Cancer Center - ElkhornElkhorn, Wisconsin  53121
United Hospital CenterClarksburg, West Virginia  26301
Dyson Center for Cancer Care at Vassar Brothers Medical CenterPoughkeepsie, New York  12601-3990
Space Coast Medical AssociatesCocoa Beach, Florida  32931
M.D. Anderson Cancer Center OrlandoOrlando, Florida  32806
New York Oncology Hematology, PCAlbany, New York  12208
Texas Oncology, PA at South Austin Cancer CenterAustin, Texas  78745
Cancer Care Northwest - NorthSpokane, Washington  99218
St. Mary's Regional Center for Cancer and Blood DisordersLewiston, Maine  04240
St. Vincent Regional Cancer CenterSanta Fe, New Mexico  87505
Catskill Regional Medical Center Cancer Care CenterHarris, New York  12742
Cancer Program of Doylestown HospitalDoylestown, Pennsylvania  18901
Norristown Regional Cancer CenterNorristown, Pennsylvania  19401
Jones Clinic - GermantownGermantown, Tennessee  38138