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A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon

Phase 3
18 Years
Open (Enrolling)
Colorectal Cancer

Thank you

Trial Information

A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon



- Compare disease-free survival of patients with resected stage II or III adenocarcinoma
of the colon treated with adjuvant chemotherapy comprising fluorouracil, leucovorin
calcium, and oxaliplatin with vs without bevacizumab.


- Compare overall survival of patients treated with these regimens.


- Determine the persistence of proteinuria after completion of bevacizumab in patients
treated with bevacizumab.

- Correlate the development of proteinuria with clinical sequelae in patients treated
with bevacizumab.

- Determine risk factors for development of proteinuria in patients treated with

- Determine the effect of discontinuing bevacizumab on hypertension in these patients.

- Determine the incidence of delayed vascular events (e.g., myocardial infarction,
Central Nervous System (CNS) ischemia, and thrombosis) in patients treated with
chemotherapy in combination with bevacizumab.

- Determine the effect of this drug on ovarian function in premenopausal women.

- Determine the incidence rate of immunogenicity and serum levels of bevacizumab in these

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
participating center and number of positive lymph nodes (0 vs 1-3 vs > 3). Patients are
randomized to 1 of 2 treatment arms.

- Arm I: Patients receive adjuvant chemotherapy comprising concurrent oxaliplatin and
leucovorin calcium IV over 2 hours on day 1. Patients also receive adjuvant
fluorouracil IV over 2-4 minutes on day 1 followed by fluorouracil IV continuously over
46 hours on days 1 and 2. Treatment repeats every 14 days for 12 courses in the absence
of disease progression or unacceptable toxicity.

- Arm II: Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also
receive adjuvant oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Treatment repeats every 14 days for 12 courses in the absence of disease progression or
unacceptable toxicity. After completion of adjuvant chemotherapy, patients continue to
receive bevacizumab alone every 14 days for 6 months in the absence of disease
progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 2,632 patients (1,316 per treatment arm) will be accrued for
this study within 2.5 years.

Inclusion Criteria


- Histologically confirmed adenocarcinoma of the colon, meeting 1 of the following
stage criteria:

- Stage II disease (T3 or 4, N0, M0)

- Stage III disease (any T, N1 or 2, M0)

- No rectal tumors

- Distal extent of tumor ≥ 12 cm from the anal verge by endoscopy or surgical

- T4 tumors involving an adjacent structure (e.g., bladder, small intestine, or ovary)
by direct extension from the primary tumor are eligible provided the following
criteria are met:

- All or a portion of the adjacent structure was removed en bloc with the primary

- All grossly visible tumor was completely resected (i.e., curative resection) in
the opinion of the surgeon

- Margins of the resected specimen not involved with malignant cells by pathology

- Not planning local radiotherapy

- En bloc complete gross resection of tumor by open laparotomy or
laparoscopically-assisted colectomy within the past 29-50 days

- Two-stage surgical procedure allowed (i.e., decompressive colostomy followed by
definitive surgical resection)

- Patients with > 1 synchronous primary colon tumor are eligible

- Disease staging based on more advanced primary tumor

- No isolated, distant, or non-contiguous intra-abdominal metastases, even if resected



- 18 and over

Performance status

- Eastern Cooperative Oncology Group (ECOG) 0-1

Life expectancy

- At least 5 years


- Absolute granulocyte count ≥ 1,500/mm^3 (unless it represents an ethnic or racial
variation of normal)

- Postoperative platelet count ≥ 100,000/mm^3

- No significant bleeding unrelated to the primary colon tumor within the past 6 months


- Bilirubin ≤ upper limit of normal (ULN) (unless due to slow conjugation of bilirubin
caused by Gilbert's disease or a similar syndrome)

- Alkaline phosphatase < 2.5 times ULN

- Aspartate Aminotransferase (AST) < 1.5 times ULN

- If AST > normal, serologic testing for hepatitis B and C is required and the
results must be negative

- No Prothrombin Time and International Normalized Ratio (PT/INR) > 1.5 unless patient
is on full-dose anticoagulants AND the following criteria are met:

- INR 2-3 on a stable dose of warfarin

- No active bleeding

- No pathological condition associated with a high risk of bleeding

- No hepatic disease that would preclude study participation

- No history of viral hepatitis or other chronic liver disease


- Serum creatinine ≤ 1.5 times ULN

- Urine protein/creatinine ratio < 1.0 OR

- < 1 g of protein on 24-hour urine collection

- No renal disease that would preclude study participation


- No uncontrolled blood pressure, defined as > 150/90 mm Hg

- No cardiovascular disease that would preclude study participation, including any of
the following:

- New York Heart Association class III or IV myocardial disease

- Myocardial infarction within the past 12 months

- Unstable angina within the past 12 months

- Symptomatic arrhythmia

- No history of transient ischemic attack or cerebrovascular accident

- No arterial thrombotic event within the past 12 months

- No symptomatic peripheral vascular disease


- No other malignancy within the past 5 years except effectively treated squamous cell
or basal cell skin cancer, melanoma in situ, carcinoma in situ of the cervix, or
carcinoma in situ of the colon or rectum

- Must be at low risk of recurrence from any prior malignancy

- No serious or non-healing wound, skin ulcer, or bone fracture

- No active gastroduodenal ulcer by endoscopy

- No clinically significant peripheral neuropathy (i.e., neurosensory or neuromotor
toxicity ≥ grade 2)

- No significant traumatic injury within the past 4 weeks

- No other nonmalignant systemic disease that would preclude study participation

- No psychiatric or addictive disorder or other condition that would preclude study

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Patients randomized to receive bevacizumab must use effective contraception
during and for 3 months after study treatment


Biologic therapy

- No concurrent prophylactic growth factors

- No concurrent biological response modifiers


- Not specified

Endocrine therapy

- Not specified


- See Disease Characteristics

- No prior radiotherapy for this malignancy

- No concurrent radiotherapy for this malignancy


- See Disease Characteristics

- Recovered from prior surgery

- More than 4 weeks since prior major surgery or open biopsy

- More than 7 days since prior core biopsy or other minor surgery (except placement of
a vascular access device)

- No concurrent or anticipated concurrent major surgery


- No prior systemic therapy for this malignancy

- No concurrent halogenated antiviral agents (e.g., sorivudine)

- No other concurrent investigational drugs

- No other concurrent antineoplastic agents

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free Survival

Outcome Description:

Where events are defined as recurrence, second primary cancer, or death from any cause

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

September 2004

Completion Date:

March 2014

Related Keywords:

  • Colorectal Cancer
  • adenocarcinoma of the colon
  • stage II colon cancer
  • stage III colon cancer
  • Colonic Neoplasms
  • Colorectal Neoplasms



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Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Chippewa County - Montevideo Hospital Montevideo, Minnesota  56265
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
Coborn Cancer Center Saint Cloud, Minnesota  56303
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Park Nicollet Health Services St. Louis Park, Minnesota  55416
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Immanuel Medical Center Omaha, Nebraska  68122
Creighton University Medical Center Omaha, Nebraska  68131-2197
Mountainside Hospital Cancer Center Montclair, New Jersey  07042
Fox Chase Cancer Center at St. Francis Medical Center Trenton, New Jersey  08629
Iredell Memorial Hospital Statesville, North Carolina  28677
Cancer Care Center at Medcenter One Hospital Bismarck, North Dakota  58501
Bismarck Cancer Center Bismarck, North Dakota  58501
St. Alexius Medical Center Bismarck, North Dakota  58502
Mid Dakota Clinic, P. C. Bismarck, North Dakota  58501
MeritCare Medical Group Fargo, North Dakota  58122
Wood County Oncology Center Bowling Green, Ohio  43402
Grandview Hospital Dayton, Ohio  45405
David L. Rike Cancer Center at Miami Valley Hospital Dayton, Ohio  45409
Good Samaritan Hospital Dayton, Ohio  45406
Fremont Memorial Hospital Fremont, Ohio  43420
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
Toledo Clinic - Oregon Oregon, Ohio  43616
St. Charles Mercy Hospital Oregon, Ohio  43616
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Firelands Regional Medical Center Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Fulton County Health Center Wauseon, Ohio  43567
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
LaFortune Cancer Center at St. John Medical Center Tulsa, Oklahoma  74104
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center Portland, Oregon  97210
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Hematology and Oncology Associates Scranton, Pennsylvania  18510
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Oncology Services of Aberdeen Aberdeen, South Dakota  57401
Baptist Regional Cancer Center at Baptist Hospital of East Tennessee Knoxville, Tennessee  37901
UMC Southwest Cancer and Research Center Lubbock, Texas  79415-3364
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Mountainview Medical Berlin, Vermont  05602
Danville Regional Medical Center Danville, Virginia  24541
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington  98902
Washington Hematology-Oncology Specialists Yakima, Washington  98902
Green Bay Oncology, Limited at St. Vincent Hospital Green Bay, Wisconsin  54301-3526
Holy Family Memorial Medical Center Cancer Care Center Manitowoc, Wisconsin  54221-1450
Welch Cancer Center at Sheridan Memorial Hospital Sheridan, Wyoming  82801
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks, Alaska  99701
Montrose Memorial Hospital Cancer Center Montrose, Colorado  81401
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
DeCesaris Cancer Institute at Anne Arundel Medical Center Annapolis, Maryland  21401
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland, Washington  98034-3013
Olympic Medical Center Port Angeles, Washington  98362
Valley Medical Center Renton, Washington  98055
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Mercy Cancer Center at Mercy Medical Center - North Iowa Mason City, Iowa  50401
Hudner Oncology Center at Saint Anne's Hospital Fall River, Massachusetts  02721
Cancer Care Center at St. Luke's Hospital Duluth, Minnesota  55805
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Washoe Cancer Services at Washoe Medical Center - Reno Reno, Nevada  89502
Capital Health System Regional Cancer Center Trenton, New Jersey  08618
Randolph Hospital Asheboro, North Carolina  27203
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
Altru Cancer Center at Altru Hospital Grand Forks, North Dakota  58201
Huron Hospital Cancer Care Center Cleveland, Ohio  44112
Euclid Hospital Cleveland, Ohio  44119
South Pointe Hospital Cancer Care Center Warrensville Heights, Ohio  44122
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
St. Joseph Medical Center Reading, Pennsylvania  19604
All Saints Cancer Center at All Saints Healthcare Racine, Wisconsin  53405
Carl and Dorothy Bennett Cancer Center at Stamford Hospital Stamford, Connecticut  06904
Florida Cancer Specialists - Sarasota Downtown Sarasota, Florida  34236
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405
McFarland Clinic, PC Ames, Iowa  50010
Covenant Cancer Treatment Center Waterloo, Iowa  50702
Cancer Center of Kansas, PA - Chanute Chanute, Kansas  66720
Cancer Center of Kansas, PA - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas, PA - Kingman Kingman, Kansas  67068
Cancer Center of Kansas, PA - Newton Newton, Kansas  67114
Cancer Center of Kansas, PA - Parsons Parsons, Kansas  67357
Cancer Center of Kansas, PA - Pratt Pratt, Kansas  67124
Cancer Center of Kansas, PA - Salina Salina, Kansas  67401
Cancer Center of Kansas, PA - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, PA - Wichita Wichita, Kansas  67214
Associates in Womens Health, PA - North Review Wichita, Kansas  67208
Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas, PA - Winfield Winfield, Kansas  67156
Haematology-Oncology Associates of Ohio and Michigan, PC Lambertville, Michigan  48144
St. Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Mercy Regional Cancer Center at Mercy Hospital Port Huron, Michigan  48060
Alegant Health Cancer Center at Bergan Mercy Medical Center Omaha, Nebraska  68124
Flower Hospital Cancer Center Sylvania, Ohio  43560
Cleo Craig Cancer Research Clinic Lawton, Oklahoma  73505
Cancer Care Associates - Mercy Campus Oklahoma City, Oklahoma  73120
Guthrie Cancer Center at Guthrie Clinic Sayre Sayre, Pennsylvania  18840
St. Joseph Cancer Center Bellingham, Washington  98225
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Oncology Alliance, SC - Milwaukee - East Glendale, Wisconsin  53212-1038
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Green Bay, Wisconsin  54311
Medical Consultants, Limited Milwaukee, Wisconsin  53215
Vince Lombardi Cancer Clinic - Sheboygan Sheboygan, Wisconsin  53081
Cancer Resource Center at King's Daughters Medical Center Ashland, Kentucky  41101
Methodist Cancer Center at Methodist Hospital - Omaha Omaha, Nebraska  68114
Saint Louis University Cancer Center Saint Louis, Missouri  63110
Community Hospital Munster, Indiana  46321
Aurora Sinai Medical Center Milwaukee, Wisconsin  53201-0342
Phoebe Cancer Center at Phoebe Putney Memorial Hospital Albany, Georgia  31702
Hematology Oncology Associates of Eastern Idaho Idaho Falls, Idaho  83404
Caritas Norwood Hospital Norwood, Massachusetts  02062
Good Samaritan Cancer Center at Good Samaritan Hospital Kearney, Nebraska  68848-1990
Elliot Regional Cancer Center at Elliot Hospital Manchester, New Hampshire  03103
AtlantiCare Regional Medical Center Pomona, New Jersey  08240
Tucker Center for Cancer Care at Orange Regional Medical Center Middletown, New York  10940-4199
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Rex Cancer Center at Rex Hospital Raleigh, North Carolina  27607
Rutherford Hospital Rutherfordton, North Carolina  28139
Cancer Treatment Center at Good Samaritan Hospital Cincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health Center Warren, Ohio  44484
York Cancer Center at Wellspan Health York, Pennsylvania  17403
AnMed Health Cancer Center Anderson, South Carolina  29621
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Martha Jefferson Hospital Cancer Care Center Charlottesville, Virginia  22901
Regional Cancer Center at Oconomowoc Memorial Hospital Oconomowoc, Wisconsin  53066
MedCentral - Mansfield Hospital Mansfield, Ohio  44903
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center Los Angeles, California  90033
St. Vincent's Medical Center Jacksonville, Florida  32203
Sherman Hospital Elgin, Illinois  60120-2198
St. Francis Hospital Evanston, Illinois  60202
Center for Cancer Care at Goshen Health System Goshen, Indiana  46526
Frederick Memorial Hospital Regional Cancer Therapy Center Frederick, Maryland  21701
Jordan Hospital Club Cancer Center Plymouth, Massachusetts  02360
St. John's Regional Medical Center Joplin, Missouri  64804
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
Underwood Memorial Hospital Woodbury, New Jersey  08096
New Mexico Cancer Care Associates Santa Fe, New Mexico  87505-7670
Central Pennsylvania Hematology and Medical Oncology Associates, PC Lemoyne, Pennsylvania  17043
Huntsville Hospital Huntsville, Alabama  35807
Nalitt Cancer Institute at Staten Island University Hospital Staten Island, New York  10305
California Cancer Care, Incorporated Greenbrae, California  94904
La Grange Memorial Hospital La Grange, Illinois  60525
Mid-Illinois Hematology-Oncology Associates at Community Cancer Center Normal, Illinois  61761
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue Waterloo, Iowa  50702
Arch Medical Services, Incorporated at Center for Cancer Care Research Saint Louis, Missouri  63141
Sletten Regional Cancer Institute at Benefis Healthcare Great Falls, Montana  59405
Lakes Region General Hospital Laconia, New Hampshire  03246
PinnacleHealth Regional Cancer Center at Polyclinic Hospital Harrisburg, Pennsylvania  17105
Cancer Care Institute of Carolina at Aiken Regional Medical Centers Aiken, South Carolina  29801
Roper St. Francis Cancer Center at Roper Hospital Charleston, South Carolina  29401
Rockwood Clinic Cancer Treatment Center Spokane, Washington  99204-2967
Florida Oncology Associates Orange Park, Florida  32073
Lipson Cancer and Blood Center at Rochester General Hospital Rochester, New York  14621
Veterans Affairs Medical Center - Augusta Augusta, Georgia  30904
Shore Memorial Hospital - Somers Point Somers Point, New Jersey  08244
Marshall University Medical Center Huntington, West Virginia  25701
Louisville Oncology at Norton Cancer Center Louisville, Kentucky  40202
Doctors Medical Center - San Pablo Campus San Pablo, California  94806
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Mercy General Hospital Sacramento, California  95819
Iowa Blood and Cancer Care Cedar Rapids, Iowa  52402
Caritas St. Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Hattiesburg Clinic, PA at Forrest General Hattiesburg, Mississippi  39401
United States Air Force Medical Center - Wright-Patterson Wright-Patterson AFB, Ohio  45433-5529
Dale and Frances Hughes Cancer Center at Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center Upland, Pennsylvania  19013
Watson Clinic, LLC Lakeland, Florida  33804-5000
Provena St. Mary's Wasser Regional Cancer Center - Kankakee Kankakee, Illinois  60901
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields Olympia Fields, Illinois  60461
Lovelace Medical Center Albuquerque, New Mexico  87108
Minnesota Oncology Hematology, PA at Maplewood Cancer Center Maplewood, Minnesota  55109
St. Mary's Regional Cancer Center at St. Mary's Medical Center Huntington, West Virginia  25702
Ocean Medical Center at Meridian Health Brick, New Jersey  08724
Heartland Oncology & Hematology Council Bluffs, Iowa  51503
Christus Schumpert Cancer Treatment Center Shreveport, Louisiana  71101
Mercy Hospital of Portland Portland, Maine  04101
South Shore Hospital South Weymouth, Massachusetts  02190
CaroMont Cancer Center at Gaston Memorial Hospital Gastonia, North Carolina  28053
Howard University Cancer Center at Howard University Hospital Washington, District of Columbia  20060
Ottumwa Regional Health Center Cancer Center Ottumwa, Iowa  52501
Northeast Georgia Cancer Care, LLC Athens, Georgia  30607
Hematology Oncology Associates, PC Albuquerque, New Mexico  87106
Jersey Shore Cancer Center at Jersey Shore University Medical Center Neptune, New Jersey  07754-0397
Mercy Regional Cancer Center at Mercy Medical Center Redding, California  96049
NSMC Cancer Center - Peabody Peabody, Massachusetts  01960
Hematology & Oncology Clinic Hattiesburg, Mississippi  39402
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center Plattsburgh, New York  12901
Virginia Cancer Institute - West End Richmond, Virginia  23230
Mercy Regional Cancer Center Janesville, Wisconsin  53547
East Alabama Medical Center Opelika, Alabama  36801-5452
Cancer Care Center at John Muir Health - Concord Campus Concord, California  94524-4110
University of Tennessee Cancer Institute - Medical Center Memphis, Tennessee  38104
Cancer Center at Providence Alaska Medical Center Anchorage, Alaska  99519-6604
Camino Medical Group - Treatment Center Mountain View, California  94040
Delnor Community Hospital - Geneva Geneva, Illinois  60134
Methodist Cancer Center at Clarian Health Indianapolis, Indiana  46202
Holy Cross Hospital Silver Spring, Maryland  20910
Cancer Institute at St. Joseph Medical Center Towson, Maryland  21204
Exeter Hospital Center for Cancer Care Exeter, New Hampshire  03833
New York Oncology Hematology, PC at Albany Regional Cancer Care Albany, New York  12208
Falck Cancer Center at Arnot Ogden Medical Center Elmira, New York  14905
New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program Hudson, New York  12534
Riverview Cancer Care Medical Associates, PC Rexford, New York  12148
New York Oncology Hematology, P.C. - Ellis Office Schenectady, New York  12308
Samaritan Hospital at Northeast Health Troy, New York  12180
Oncology Hematology Care, Incorporated - Blue Ash Cincinnati, Ohio  45242
Ephrata Cancer Center at Ephrata Community Hospital Ephrata, Pennsylvania  17522
Cancer Center at Riddle Memorial Hospital Media, Pennsylvania  19063
Frankford Hospital - Torresdale Campus Philadelphia, Pennsylvania  19114
Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County Martinsville, Virginia  24115
Peninsula Cancer Institute Newport News, Virginia  23601
Overlake Cancer Center at Overtake Hospital Medical Center Bellevue, Washington  98004
St. Mary Regional Cancer Center at St. Mary Medical Center Walla Walla, Washington  99362
Richard G. Laube Cancer Center at ACMH Kittanning, Pennsylvania  16201
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital Cooperstown, New York  13326
Ida M. and Cecil H. Green Cancer Center at Scripps Clinic La Jolla, California  92037-1027
Vince Lombardi Cancer Center - Elkhorn Elkhorn, Wisconsin  53121
United Hospital Center Clarksburg, West Virginia  26301
Dyson Center for Cancer Care at Vassar Brothers Medical Center Poughkeepsie, New York  12601-3990
Space Coast Medical Associates Cocoa Beach, Florida  32931
M.D. Anderson Cancer Center Orlando Orlando, Florida  32806
New York Oncology Hematology, PC Albany, New York  12208
Texas Oncology, PA at South Austin Cancer Center Austin, Texas  78745
Cancer Care Northwest - North Spokane, Washington  99218
St. Mary's Regional Center for Cancer and Blood Disorders Lewiston, Maine  04240
St. Vincent Regional Cancer Center Santa Fe, New Mexico  87505
Catskill Regional Medical Center Cancer Care Center Harris, New York  12742
Cancer Program of Doylestown Hospital Doylestown, Pennsylvania  18901
Norristown Regional Cancer Center Norristown, Pennsylvania  19401
Jones Clinic - Germantown Germantown, Tennessee  38138