Health-Related Outcomes For Hodgkin's Disease Survivors
- Determine the cumulative incidence and characterize the spectrum of selected adverse
physiologic and psychosocial outcomes, using self-report and clinical evaluation, in
patients previously treated for childhood Hodgkin's lymphoma.
- Compare the cumulative incidence and spectrum of self-reported adverse outcomes of
these patients, using data collected at a comparable time period after diagnosis, with
Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).
- Compare self-reported health-related outcomes with outcomes detected by clinical
evaluation and medical record review of each group of patients.
OUTLINE: This is a cohort, cross-sectional, multicenter study.
- Contemporary group: Patients complete a self-report of long-term outcomes questionnaire
and a comprehensive psychosocial questionnaire. A medical record review is then
performed. Patients then undergo a comprehensive risk-based clinical evaluation with
specific examinations and studies based upon the Children's Oncology Group Late Effects
Screening Guidelines and the patients' specific therapeutic exposures.
- Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview
and have medical records reviewed to validate select self-reported long-term outcomes.
Patient replies from the baseline CCSS questionnaire (which was completed at certain
timepoints after diagnosis) are reviewed for targeted long-term outcomes.
PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.
Debra L. Friedman, MD, MS
Vanderbilt-Ingram Cancer Center
United States: Federal Government
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|
|Children's Hospital of Philadelphia||Philadelphia, Pennsylvania 19104|
|University of Chicago Cancer Research Center||Chicago, Illinois 60637|
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Children's Hospital and Regional Medical Center - Seattle||Seattle, Washington 98105|
|St. Jude Children's Research Hospital||Memphis, Tennessee 38105-2794|
|Yale Cancer Center||New Haven, Connecticut 06520-8028|
|Hackensack University Medical Center Cancer Center||Hackensack, New Jersey 07601|
|Cincinnati Children's Hospital Medical Center||Cincinnati, Ohio 45229-3039|
|Rhode Island Hospital Comprehensive Cancer Center||Providence, Rhode Island 02903|
|Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas||Dallas, Texas 75390|
|St. Vincent Hospital Regional Cancer Center||Green Bay, Wisconsin 54307-3508|
|James P. Wilmot Cancer Center at University of Rochester Medical Center||Rochester, New York 14642|
|Lucile Packard Children's Hospital at Stanford University Medical Center||Palo Alto, California 95798|
|Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center||New York, New York 10032|