Trial Information

Health-Related Outcomes For Hodgkin's Disease Survivors

OBJECTIVES:

- Determine the cumulative incidence and characterize the spectrum of selected adverse
physiologic and psychosocial outcomes, using self-report and clinical evaluation, in
patients previously treated for childhood Hodgkin's lymphoma.

- Compare the cumulative incidence and spectrum of self-reported adverse outcomes of
these patients, using data collected at a comparable time period after diagnosis, with
Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).

- Compare self-reported health-related outcomes with outcomes detected by clinical
evaluation and medical record review of each group of patients.

OUTLINE: This is a cohort, cross-sectional, multicenter study.

- Contemporary group: Patients complete a self-report of long-term outcomes questionnaire
and a comprehensive psychosocial questionnaire. A medical record review is then
performed. Patients then undergo a comprehensive risk-based clinical evaluation with
specific examinations and studies based upon the Children's Oncology Group Late Effects
Screening Guidelines and the patients' specific therapeutic exposures.

- Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview
and have medical records reviewed to validate select self-reported long-term outcomes.
Patient replies from the baseline CCSS questionnaire (which was completed at certain
timepoints after diagnosis) are reviewed for targeted long-term outcomes.

PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.