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Health-Related Outcomes For Hodgkin's Disease Survivors

Open (Enrolling)
Long-term Effects Secondary to Cancer Therapy in Children, Lymphoma

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Trial Information

Health-Related Outcomes For Hodgkin's Disease Survivors


- Determine the cumulative incidence and characterize the spectrum of selected adverse
physiologic and psychosocial outcomes, using self-report and clinical evaluation, in
patients previously treated for childhood Hodgkin's lymphoma.

- Compare the cumulative incidence and spectrum of self-reported adverse outcomes of
these patients, using data collected at a comparable time period after diagnosis, with
Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).

- Compare self-reported health-related outcomes with outcomes detected by clinical
evaluation and medical record review of each group of patients.

OUTLINE: This is a cohort, cross-sectional, multicenter study.

- Contemporary group: Patients complete a self-report of long-term outcomes questionnaire
and a comprehensive psychosocial questionnaire. A medical record review is then
performed. Patients then undergo a comprehensive risk-based clinical evaluation with
specific examinations and studies based upon the Children's Oncology Group Late Effects
Screening Guidelines and the patients' specific therapeutic exposures.

- Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview
and have medical records reviewed to validate select self-reported long-term outcomes.
Patient replies from the baseline CCSS questionnaire (which was completed at certain
timepoints after diagnosis) are reviewed for targeted long-term outcomes.

PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.

Inclusion Criteria


- Contemporary cohort

- At least 5 years since diagnosis of Hodgkin's lymphoma

- Diagnosed between the years 1987-2001

- 21 and under at diagnosis

- No evidence of disease

- Prior treatment on 1 of the following protocols during the years 1987-2001:

- Children's Cancer Group (CCG) CCG-5942, CCG-59704

- Pediatric Oncology Group (POG) POG-8625, POG-8725, POG-9425, POG-9426

- Pediatric Hodgkin's Consortium: VAMP, VEPA, VAMP/COP

- Institutional protocols COPP/ABV, MOPP/ABVD, ABVD

- Childhood Cancer Survivor Study (CCSS) Hodgkin's lymphoma cohort

- Current enrollment in the CCSS

- Diagnosed between the years 1976-1986

- Completed baseline questionnaire at comparable timepoints (as the contemporary
cohort) after diagnosis



- Any age

Performance status

- Not specified

Life expectancy

- Not specified


- Not specified


- Not specified


- Not specified


Biologic therapy

- Not specified


- Not specified

Endocrine therapy

- Not specified


- Not specified


- Not specified

Type of Study:


Study Design:


Principal Investigator

Debra L. Friedman, MD, MS

Investigator Role:

Principal Investigator

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center


United States: Federal Government

Study ID:




Start Date:

December 2004

Completion Date:

Related Keywords:

  • Long-term Effects Secondary to Cancer Therapy in Children
  • Lymphoma
  • long-term effects secondary to cancer therapy in children
  • stage I childhood Hodgkin lymphoma
  • stage II childhood Hodgkin lymphoma
  • stage III childhood Hodgkin lymphoma
  • stage IV childhood Hodgkin lymphoma
  • Hodgkin Disease
  • Lymphoma



Memorial Sloan-Kettering Cancer Center New York, New York  10021
Children's Hospital of Philadelphia Philadelphia, Pennsylvania  19104
University of Chicago Cancer Research Center Chicago, Illinois  60637
Vanderbilt-Ingram Cancer Center Nashville, Tennessee  37232-6838
Children's Hospital and Regional Medical Center - Seattle Seattle, Washington  98105
St. Jude Children's Research Hospital Memphis, Tennessee  38105-2794
Yale Cancer Center New Haven, Connecticut  06520-8028
Hackensack University Medical Center Cancer Center Hackensack, New Jersey  07601
Cincinnati Children's Hospital Medical Center Cincinnati, Ohio  45229-3039
Rhode Island Hospital Comprehensive Cancer Center Providence, Rhode Island  02903
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas  75390
St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54307-3508
James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York  14642
Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California  95798
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York  10032