A Phase II Evaluation Of Pemetrexed (ALIMTA, LY231514, IND #40061) In The Treatment Of Recurrent Or Persistent Endometrial Carcinoma
- Determine the antitumor activity of pemetrexed disodium in patients with persistent or
recurrent endometrial adenocarcinoma that failed higher priority treatment protocols.
- Determine the nature and degree of toxicity of this drug in these patients.
OUTLINE: This is a multicenter study.
Patients receive pemetrexed disodium IV over 10 minutes on day 1. Courses repeat every 21
days in the absence of disease progression or unacceptable toxicity.
Beginning 7 days before and continuing until 3 weeks after the last dose of pemetrexed
disodium, patients also receive oral folic acid daily and cyanocobalamin (vitamin B_12)
intramuscularly every 9 weeks.
Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: Approximately 19-51 patients will be accrued for this study within 1-3.4
Masking: Open Label, Primary Purpose: Treatment
David S. Miller, MD
Simmons Cancer Center
United States: Federal Government
|CCOP - Carle Cancer Center||Urbana, Illinois 61801|
|Hinsdale Hematology Oncology Associates||Hinsdale, Illinois 60521|
|West Michigan Cancer Center||Kalamazoo, Michigan 49007-3731|
|Case Comprehensive Cancer Center||Cleveland, Ohio 44106-5065|
|Avera Cancer Institute||Sioux Falls, South Dakota 57105|
|Holden Comprehensive Cancer Center at University of Iowa||Iowa City, Iowa 52242-1002|
|Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill||Chapel Hill, North Carolina 27599-7570|
|Cleveland Clinic Taussig Cancer Center||Cleveland, Ohio 44195|
|Hulston Cancer Center at Cox Medical Center South||Springfield, Missouri 65807|
|St. John's Regional Health Center||Springfield, Missouri 65804|
|SUNY Downstate Medical Center||Brooklyn, New York 11203|
|Lake/University Ireland Cancer Center||Mentor, Ohio 44060|
|Cancer Care Associates - Midtown Tulsa||Tulsa, Oklahoma 74104|
|St. Vincent Indianapolis Hospital||Indianapolis, Indiana 46260|
|Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas||Dallas, Texas 75390|
|Riverside Methodist Hospital Cancer Care||Columbus, Ohio 43214|
|Jonsson Comprehensive Cancer Center at UCLA||Los Angeles, California 90095-1781|
|University of Mississippi Cancer Clinic||Jackson, Mississippi 39216-4505|
|Oklahoma University Cancer Institute||Oklahoma City, Oklahoma 73104|
|Rosenfeld Cancer Center at Abington Memorial Hospital||Abington, Pennsylvania 19001|
|David L. Rike Cancer Center at Miami Valley Hospital||Dayton, Ohio 45409|
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|
|Alamance Cancer Center at Alamance Regional Medical Center||Burlington, North Carolina 27216|