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A Phase II Study of Single Agent Depsipeptide (FK228) (NSC 630176; IND 51,810) in Relapsed Small Cell Lung Cancer

Phase 2
18 Years
Not Enrolling
Recurrent Small Cell Lung Cancer

Thank you

Trial Information

A Phase II Study of Single Agent Depsipeptide (FK228) (NSC 630176; IND 51,810) in Relapsed Small Cell Lung Cancer


I. To evaluate the response rate of patients with histologically or cytologically proven
small cell lung cancer (SCLC) treated with depsipeptide in the "sensitive" relapse setting.


I. To describe the overall survival and failure-free survival of patients with
histologically proven recurrent SCLC treated with depsipeptide.

II. To evaluate the toxicity of depsipeptide in patients with relapsed SCLC. III. To
evaluate surrogate biological markers from peripheral blood mononuclear cells and buccal
epithelial cells: p53 acetylation, histone acetylation, p21CIP1 expression.


Patients receive FR901228 (depsipeptide) IV over 4 hours on days 1, 8, and 15. Treatment
repeats every 28 days for at least 6 courses in the absence of disease progression or
unacceptable toxicity. Patients who have continuing tumor response or stable disease after 6
courses receive 2 additional courses beyond best response.

Patients are followed every 3 months for 1 year and then every 6 months for 3 years.

Inclusion Criteria:

- Either histologic or cytologic documentation of recurrent small cell lung carcinoma

- No more than 1 prior chemotherapy regimen; must have recurrent disease after
treatment with a platinum agent (either cisplatin or carboplatin); prior chemotherapy
must have been completed ≥90 days prior to documentation of relapse

- >= 4 weeks since prior radiation therapy; prior radiation therapy is allowed either
in the context of curative intent combined modality treatment for limited stage
disease, prophylactic cranial radiation or palliative radiation (to the chest, brain,
or other sites) initially or at relapse

- Prior surgery is allowed provided patients have completely recovered from effects of
procedure and >= 2 weeks have elapsed

- No prior treatment with depsipeptide

- No history of allergic reactions attributed to compounds of similar chemical or
biologic composition to depsipeptide

- No current treatment with any other investigational agent or drugs known to have HDI
activity (HDAC or histone deacetylase inhibitor) such as sodium valproate

- Patients with treated/controlled brain mets (defined as no need for further radiation
and no requirements for steroids to control peri-tumoral edema) are eligible for this
study; however, patients requiring treatment with enzyme inducing anti-convulsant
drugs are not eligible; these include, but are not limited to, phenytoin,
phenobarbital, carbamazepine, felbamate and primidone

- All Patients must have Measurable Disease

- Measurable disease is defined as at least one lesion that can be accurately
measured in at least one dimension; the longest diameter of measurable lesions
must be >= 20 mm with conventional techniques or >= 10 mm with spiral CT scan;
lesions that are not considered measurable include the following:

- Bone lesions

- Leptomeningeal disease

- Ascites

- Pleural/pericardial effusion

- Abdominal masses that are not confirmed and followed by imaging techniques

- Cystic lesions

- Tumor lesions situated in a previously irradiated area

- ECOG Performance Status 0-1

- No significant cardiac disease, including:

- Congestive heart failure that meets New York Heart Association (NYHA) class III/IV
definitions, history of myocardial infarction within one year of study entry,
uncontrolled dysrhythmias, or poorly controlled angina

- History of serious ventricular arrhythmia (VT or VF, >= 3 beats in a row), QTc >= 500
msec, or LVEF =< 40% by MUGA

- Evidence of left ventricular hypertrophy by echocardiographic criteria or by EKG
criteria (Cornell voltage criteria):

For Men: S in V3 plus R in aVL > 2.8 mV (28mm) For Women: S in V3 + R in aVL > 2.0 mV

- Patients may not be co-medicated with an agent that causes QTc prolongation

- Patients with immune deficiency are at increased risk of lethal infections when
treated with marrow-suppressive therapy; therefore, HIV-positive patients receiving
combination anti-retroviral therapy are not eligible because of possible
pharmacokinetic interactions with depsipeptide

- No current treatment with potassium wasting diuretics (e.g., hydroclorothiazide);
patients on such diuretics should be switched to a potassium sparing diuretic or
another antihypertensive medication prior to registration

- Granulocytes >= 1,500/μl

- Platelets >= 100,000/μl

- Total Bilirubin =< 1.5 x ULN

- AST (SGOT) =< 2.5 x ULN

- Creatinine ≤1.5 x ULN OR Calculated Creatinine Clearance >= 60 ml/min

Exclusion Criteria:

- Non-pregnant and non-nursing because of significant risk to the fetus/infant; the
effects of depsipeptide on the developing human fetus at the recommended therapeutic
dose are unknown; for this reason and because histone deacetylase inhibitors are
known to be teratogenic, women of child-bearing potential and men must agree to use
adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to and for the entire duration of participation and for at least 6 weeks after
completion of treatment

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Objective response rate

Outcome Description:

95% confidence intervals will be estimated.

Outcome Time Frame:

Up to 4 years

Safety Issue:


Principal Investigator

Gregory Otterson

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B


United States: Food and Drug Administration

Study ID:




Start Date:

May 2004

Completion Date:

Related Keywords:

  • Recurrent Small Cell Lung Cancer
  • Lung Neoplasms
  • Small Cell Lung Carcinoma



Ohio State University Columbus, Ohio  43210