Trial Information

Stress-Immune Response and Cervical Cancer

OBJECTIVES:

- Compare quality of life (QOL) at baseline and changes in QOL, immune response, and
neuroendocrine parameters over time in patients who have completed treatment for stage
I-III cervical cancer receiving psychosocial telephone counseling vs usual care.

- Correlate psychosocial measures with immunologic stance.

OUTLINE: This is a randomized, controlled, parallel-group study. Patients are randomized to
1 of 2 intervention arms.

- Arm I: Patients undergo psychosocial telephone counseling comprising 5 weekly sessions
and a 1-month follow-up session to learn strategies for reducing stress.

- Arm II: Patients undergo usual care for approximately 4 months. All patients complete
questionnaires and Quality of life assessment at baseline and at 4 months. They also
undergo saliva and blood sample collections at baseline and at 4 months for neuroimmune
studies.

PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.