Neurobehavioral Outcomes in Childhood Acute Lymphoblastic Leukemia. A Limited Non-Therapeutic Stucy
- Compare neurobehavioral functioning, specifically memory, attention, executive
function, visual-motor integration, and processing speed, in children previously
treated with steroids (prednisone vs dexamethasone) and intrathecal therapy
(methotrexate alone vs methotrexate, cytarabine, and hydrocortisone) for childhood
acute lymphoblastic leukemia.
- Correlate non-treatment risk factors, such as gender, age at diagnosis, and time since
termination of prior therapy, with impaired neurobehavioral function in these patients.
- Correlate neurobehavioral complications with quality-of-life of these patients.
OUTLINE: This is a multicenter, cohort study. Patients are assigned to 1 of 2 cohorts (prior
treatment per CCG-1922 [prednisone vs dexamethasone] vs prior treatment per CCG-1952
[intrathecal (IT) methotrexate vs IT methotrexate, cytarabine, and hydrocortisone]).
Patients in each cohort are stratified according to age at diagnosis, gender, and time since
prior treatment termination.
- Cohort A (CCG-1922): Patients undergo physical and neurological examination,
neurobehavioral evaluation, and quality of life assessment. Neurobehavioral evaluations
assess memory, attention, and executive function.
- Cohort B (CCG-1952): Patients undergo evaluation as above. Neurobehavioral evaluations
assess visual-motor integration and processing speed.
PROJECTED ACCRUAL: A total of 448 patients (224 per cohort) will be accrued for this study
within 4 years.
Primary Purpose: Supportive Care
Nina S. Kadan-Lottick, MD, MSPH
United States: Federal Government
|Children's Hospital of Philadelphia||Philadelphia, Pennsylvania 19104|
|Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center||Farmington, Connecticut 06360-2875|
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Holden Comprehensive Cancer Center at University of Iowa||Iowa City, Iowa 52242-1002|
|Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill||Chapel Hill, North Carolina 27599-7570|
|Children's National Medical Center||Washington, District of Columbia 20010-2970|
|Children's Mercy Hospital||Kansas City, Missouri 64108|
|Children's Hospital of Pittsburgh||Pittsburgh, Pennsylvania 15213|
|Children's Hospital and Regional Medical Center - Seattle||Seattle, Washington 98105|
|Phoenix Children's Hospital||Phoenix, Arizona 85016-7710|
|Loma Linda University Cancer Institute at Loma Linda University Medical Center||Loma Linda, California 92354|
|Jonathan Jaques Children's Cancer Center at Miller Children's Hospital||Long Beach, California 90801|
|Yale Cancer Center||New Haven, Connecticut 06520-8028|
|Blank Children's Hospital||Des Moines, Iowa 50309|
|NYU Cancer Institute at New York University Medical Center||New York, New York 10016|
|Cincinnati Children's Hospital Medical Center||Cincinnati, Ohio 45229-3039|
|Primary Children's Medical Center||Salt Lake City, Utah 84113-1100|
|Jonsson Comprehensive Cancer Center at UCLA||Los Angeles, California 90095-1781|
|Childrens Hospital Los Angeles||Los Angeles, California 90027|
|Children's Hospital and Research Center Oakland||Oakland, California 94609|
|Children's Hospital Center for Cancer and Blood Disorders||Aurora, Colorado 80045|
|Alfred I. duPont Hospital for Children||Wilmington, Delaware 19803|
|Indiana University Melvin and Bren Simon Cancer Center||Indianapolis, Indiana 46202-5289|
|Lucille P. Markey Cancer Center at University of Kentucky||Lexington, Kentucky 40536-0093|
|C.S. Mott Children's Hospital at University of Michigan Medical Center||Ann Arbor, Michigan 48109-0286|
|Butterworth Hospital at Spectrum Health||Grand Rapids, Michigan 49503-2560|
|Masonic Cancer Center at University of Minnesota||Minneapolis, Minnesota 55455|
|Children's Hospitals and Clinics of Minnesota - Minneapolis||Minneapolis, Minnesota 55404|
|Nationwide Children's Hospital||Columbus, Ohio 43205-2696|
|M. D. Anderson Cancer Center at University of Texas||Houston, Texas 77030-4009|
|Oregon Health and Science University Cancer Institute||Portland, Oregon 97239-3098|