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Phase I Study of Weekly Clofarabine for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia

Phase 1
Not Enrolling
Chronic Lymphocytic Leukemia, Leukemia

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Trial Information

Phase I Study of Weekly Clofarabine for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia

Clofarabine is a new chemotherapy drug that is designed to interfere with the growth and
development of cancer cells.

Before you can start treatment on the study, you will have what are called "screening
tests". These tests will help the doctor decide if you are eligible to take part in the
study. You will have a complete medical history and physical examination. You will also be
asked about what medications you are taking currently and about the level of your daily
activities. Routine blood tests (about 2 tablespoons) will be done within 14 days before the
start of the study to make sure that you are not at increased risk for developing side
effects. You may have bone marrow samples collected. To collect a bone marrow sample, an
area of the hip or chest bone is numbed with anesthetic and a small amount of bone marrow is
withdrawn through a large needle.

If you are found to be eligible, you will receive clofarabine as a 1-hour infusion into a
vein once once every 2 weeks for 4 weeks. This cycle makes up one treatment course.

The drug is evaluated at different dose levels. The first three patients will start with a
lower dose. Unless serious side effects occur, the next group of patients (usually groups
are 3 patients, although they can be expanded to include more patients if needed) will
receive a higher dose.

If you show a response and do not experience any severe side effects, you can receive up to
a total of 6 courses of therapy. During each course, clofarabine is given the same way as
during the first course. However, the dose of clofarabine may be lowered during later
courses to decrease the risk of side effects that may have occurred in previous courses. If
the disease gets worse or you experience any intolerable side effects, you will be taken off
the study and your doctor will discuss other treatment options with you.

Before every treatment course, your doctor will perform a physical exam, including
measurement of your weight and vital signs. You will be asked about the level of your daily
activities and how you are feeling. At least once every two weeks (more often if your doctor
feels it is necessary), you will have blood samples (about 1-2 teaspoons) collected for
routine lab tests. Repeat bone marrows will be collected after the third and sixth course.
However, if you complete the study before the third course, the bone marrow may be taken
then. No bone marrow may be taken if the condition of your disease is obvious from the

You will need to stay in Houston for the first 4 weeks of treatment. After that, you may
return to your home but you will still have to return to Houston to receive the clofarabine
treatment. You may choose to have check-up visits and blood tests with your local doctor.

After you finished your treatment, and as long you are participating on this study, you will
be scheduled every 3-6 months to check on the status of the disease and your overall health.

This is an investigational study. Clofarabine is authorized by the FDA for use in research
only. Up to 36 participants will take part in this study. All will be enrolled at M. D.

Inclusion Criteria:

1. Patients with chronic lymphocytic leukemia (CLL), CLL/PLL (as defined by FAB), and
PLL (B- and T-cell phenotypes) who have relapsed from or are refractory to at least
one fludarabine-based regimen.

2. Absolute neutrophil count (ANC) >= 1 x 10(9)/L and platelet count >= 50 x 10(9)/L

3. Adequate liver function (total bilirubin <= 1.5 x ULN, SGPT <= 2.5 x ULN) and renal
function (serum creatine <= 1.5 x ULN).

4. ECOG performance status <= 2.

Exclusion Criteria:

1. Patients with NYHA >= grade 3 heart disease as assessed by history and/or physical

2. Pregnant or breastfeeding women or patients who are unwilling or unable to practice
adequate contraception.

3. Chemotherapy within 4 weeks of starting therapy, or concurrent anticancer therapy
(chemotherapy, radiotherapy, or biologic therapy)

4. Other malignancy within 3 years except in situ carcinoma

5. Unwilling or unable to provide informed consent

6. Hypersensitivity to nucleoside analogues

7. Other significant medical condition that compromises safety, compliance or study
conduct, including but not limited to uncontrolled hypertension, unstable angina,
congestive heart failure, myocardial infarction within 6 months, ventricular
arrhythmia, diabetes, active infection, pulmonary fibrosis, and chronic hepatitis

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Maximum tolerated dose (MTD)

Outcome Time Frame:

Following each 4 week treatment cycle

Safety Issue:


Principal Investigator

Stefan Faderl, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

May 2004

Completion Date:

June 2007

Related Keywords:

  • Chronic Lymphocytic Leukemia
  • Leukemia
  • Chronic Lymphocytic Leukemia
  • CLL
  • Leukemia
  • Clofarabine
  • Clofarex
  • Clolar
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid



The University of Texas M.D. Anderson Cancer Center Houston, Texas