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Detection of Hepatocellular Carcinoma by Positron Emission Tomography With C-Acetate-11 and F-fluorodeoxyglucose-18


N/A
18 Years
N/A
Not Enrolling
Both
Liver Cancer

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Trial Information

Detection of Hepatocellular Carcinoma by Positron Emission Tomography With C-Acetate-11 and F-fluorodeoxyglucose-18

Inclusion Criteria


INCLUSION:

- Biopsy-proved HCC (stage I and II by conventional staging) or one or more of the
following in a patient with clinically documented cirrhosis:

- AFP > 200 mg/dL;

- A contrast-enhancing tumor mass (>1 cm) by CT or MRI; or

- A tumor mass confirmed by arteriography.

- Patient must provide written informed consent and have completed conventional imaging
and staging before initiation of PET imaging.

EXCLUSION:

- Pediatric patients under the age of 18 will be excluded from consideration from this
study.

- Patients with a known prior malignancy (with the exception of basal cell carcinoma of
the skin and carcinoma in situ of the cervix) within 5 years will be excluded from
entry into the study. However, patients with a prior HCC thought to have a new
primary or recurrent HCC are eligible.

- Pregnant and breastfeeding patients.

- Patients with poorly controlled diabetes mellitus (fasting blood glucose level > 200
mg/dL)

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Relative sensitivity and specificity of positron emission tomography (PET) scanning with carbon-11 acetate and fludeoxyglucose F 18

Safety Issue:

No

Principal Investigator

William C. Chapman, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

CDR0000358907

NCT ID:

NCT00081094

Start Date:

September 2003

Completion Date:

September 2005

Related Keywords:

  • Liver Cancer
  • adult primary hepatocellular carcinoma
  • recurrent adult primary liver cancer
  • localized resectable adult primary liver cancer
  • Carcinoma
  • Liver Neoplasms
  • Carcinoma, Hepatocellular

Name

Location

Washington University School of MedicineSaint Louis, Missouri  63110