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A PHASE I STUDY OF DECITABINE IN COMBINATION WITH VALPROIC ACID IN PATIENTS WITH SELECTED HEMATOLOGIC MALIGNANCIES


Phase 1
18 Years
N/A
Open (Enrolling)
Both
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Recurrent Adult Acute Myeloid Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Untreated Adult Acute Myeloid Leukemia

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Trial Information

A PHASE I STUDY OF DECITABINE IN COMBINATION WITH VALPROIC ACID IN PATIENTS WITH SELECTED HEMATOLOGIC MALIGNANCIES


PRIMARY OBJECTIVES:

I. Determine the minimally effective pharmacological dose (MEPD) of decitabine in patients
with refractory or relapsed acute myeloid leukemia or with previously treated chronic
lymphocytic lymphoma or small lymphocytic lymphoma.

II. Determine the maximum tolerated dose (MTD) of valproic acid in combination with the MEPD
of decitabine in these patients.

III. Determine the MEPD of valproic acid in combination with decitabine in these patients.

IV. Determine the qualitative and quantitative toxic effects of decitabine alone and in
combination with valproic acid, in terms of organ specificity, time course, predictability,
and reversibility in these patients.

SECONDARY OBJECTIVES:

I. Determine the therapeutic response in patients treated with decitabine alone and in
combination with valproic acid.

II. Determine the pharmacokinetics of this regimen in these patients. III. Determine
kinetics of methyltransferase activity and re-expression of select target genes in AML [p15,
estrogen receptor (ER), WT-1, calcitonin, MYOD1] and in CLL/SLL [DERMO-1, DAPK, and ID4]
known to be methylated in primary tumor cells.

IV. Correlate baseline and post-treatment changes in DNA methyltransferases (MT1, MT3a, and
MT3b) expression with achievement of decitabine MEPD, toxicity, treatment resistance, and
disease response in these patients.

V. Determine kinetics of HDAC enzyme inhibition and changes in the acetylation status of
histones H3 or H4 following treatment with the combination. These parameters will be used to
define the MEPD of the combination.

VI. Examine baseline and post-therapy changes in the "histone code' in both AML and CLL
cells by assessment of the acetylation and methylation status of histones H3 and H4 lysine
residues using both Western Blot and Mass Spectrometry techniques.

OUTLINE: This is a dose-escalation study. Patients are stratified according to disease
(refractory or relapsed acute myeloid leukemia vs chronic lymphocytic leukemia or small
lymphocytic lymphoma).

Patients receive decitabine IV over 1 hour on days 1-5 or 1-10. Treatment repeats every 28
days.

Cohorts of 6 patients receive escalating doses of decitabine until the minimally effective
pharmacological dose (MEPD) is determined. The MEPD is defined as the dose at which at least
5 of 6 patients meet gene methylation criteria and no more than 1 of 6 patients experiences
dose-limiting toxicity (DLT).

Once the MEPD is determined, patients receive decitabine at that dose level administered as
above and oral valproic acid three times daily on days 5-21. Treatment repeats every 28
days.

Cohorts of 3-6 patients receive escalating doses of valproic acid until the maximum
tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2
of 3 or 2 of 6 patients experience DLT. The MEPD of valproic acid is then determined using
established gene methylation and toxicity criteria. Treatment continues for up to 24 months
in the absence of disease progression or unacceptable toxicity.

Patients are followed for survival.


Inclusion Criteria:



- Patients with AML (Stratum I) or CLL/SLL (Stratum II) will be enrolled

- Patients in stratum I will have one of the following:

- Primary refractory or relapsed (in 1 year or less) disease and not a candidate
for potentially curative therapy

- Untreated AML patients who are not candidates for chemotherapy

- Patients in stratum I must have a normal WBC (=< 10 x 10^9/L) or a WBC =< 40 x
10^9/L that is stable for 1 week (this may be sustained with hydroxyurea prior
to starting therapy and during the first 4 days of therapy if clinically
indicated)

- Patients in stratum II will have received at least one prior therapy for CLL/SLL that
has included a purine analog; patients in stratum II with a history of severe
autoimmune disease or requiring therapy with chronic corticosteroids or who have any
other specific relative contraindications to receive a purine analog and, therefore,
have received another form of therapy that include alkylating agents will be eligible
to participate

- Performance status - ECOG 0-2

- At least 12 weeks life expectancy

- Stratum II:

- No uncontrolled autoimmune hemolytic anemia

- No idiopathic thrombocytopenia purpura

- Bilirubin =< 1.5 mg/dL

- ALT and AST =< 2 times upper limit of normal

- Creatinine =< 2.0 mg/dL

- No active infection requiring IV antibiotics

- HIV negative

- No other severe medical condition that would preclude study participation

- No psychiatric condition that would preclude study compliance

- No history of seizures

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- More than 14 days since prior chemotherapy (except hydroxyurea)

- No prior FR901228 (depsipeptide) for step 2 of this study

- No other concurrent chemotherapy

- No concurrent corticosteroids for antiemetic therapy

- No concurrent hormonal therapy except for the following:

- Steroids for treatment of adrenal failure or septic shock

- Insulin for diabetes

- Tamoxifen or equivalent for breast cancer prevention or adjuvant therapy

- Estrogens or progestins for gynecologic indications

- More than 14 days since prior radiotherapy

- No concurrent palliative radiotherapy

- No concurrent anticonvulsant medication, including valproic acid

Type of Study:

Interventional

Study Design:

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

MEPD of single agent decitabine

Outcome Time Frame:

10 days

Safety Issue:

Yes

Principal Investigator

Kristie Blum

Investigator Role:

Principal Investigator

Investigator Affiliation:

Ohio State University Comprehensive Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2012-01447

NCT ID:

NCT00079378

Start Date:

March 2004

Completion Date:

Related Keywords:

  • Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
  • Adult Acute Myeloid Leukemia With Del(5q)
  • Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
  • Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
  • Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
  • Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
  • Recurrent Adult Acute Myeloid Leukemia
  • Recurrent Small Lymphocytic Lymphoma
  • Refractory Chronic Lymphocytic Leukemia
  • Untreated Adult Acute Myeloid Leukemia
  • Congenital Abnormalities
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Lymphoma

Name

Location

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, Ohio  43210-1240