Trial Information

A Phase II Study VEPEMB In Patients With Hodgkin's Lymphoma Aged ≥ 60 Years

OBJECTIVES:

Primary

- Determine the efficacy and toxicity of vinblastine, cyclophosphamide, procarbazine,
prednisolone, etoposide, mitoxantrone, and bleomycin in older patients with Hodgkin's
lymphoma.

- Determine whether the application of the Hasenclever prognostic index is valid in these
patients at diagnosis.

OUTLINE: This is an open-label, multicenter study.

- Chemotherapy: Patients receive vinblastine IV and cyclophosphamide IV on day 1; oral
procarbazine and oral prednisolone on days 1-5; oral etoposide on days 15-19; and
mitoxantrone IV and bleomycin IV on day 15. Treatment repeats every 28 days, in the
absence of disease progression or unacceptable toxicity, for a total of 3 courses in
patients with early (stage IA or IIA) disease or 6 courses in patients with advanced
(stage IB or IIB-IV) disease.

- Radiotherapy: Patients with early stage disease receive involved-field radiotherapy.
Patients with advanced stage disease receive radiotherapy limited to sites of initial
bulky disease or residual disease. Radiotherapy begins 4 weeks after the completion of
chemotherapy.

Patients are followed monthly for 3 months, every 3 months for 6 months, and then annually
thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

PROJECTED ACCRUAL: A total of 150 patients will be accrued for this study within 36 months.