Know Cancer

or
forgot password

Use Of Proteomic Analysis Of Serum Samples For Detection Of Non-Small Cell Lung Cancer


N/A
18 Years
N/A
Not Enrolling
Both
Lung Cancer

Thank you

Trial Information

Use Of Proteomic Analysis Of Serum Samples For Detection Of Non-Small Cell Lung Cancer


OBJECTIVES:

Primary

- Determine, prospectively, whether serum proteomic profiling can predict the presence of
primary non-small cell lung cancer in patients with clinically suspicious stage I lung
lesions who are undergoing lung resection.

Secondary

- Correlate the serum proteomic profile with pathologic nodal status and histopathologic
features of primary lung cancer in these patients.

- Correlate the initial and follow-up serum proteomic profile with overall and
cancer-specific survival of these patients.

- Correlate changes in the proteomic profile (preoperative to postoperative) with overall
and cancer-specific survival of these patients.

Tertiary

- Determine whether novel molecular strategies can predict the presence of lung cancer
and/or the biologic behavior of an individual cancer in these patients.

OUTLINE: Patients undergo lung resection. Patients also undergo preoperative and
postoperative collection of whole blood and serum for proteomic profiling using
surface-enhanced laser desorption/ionization-time of flight mass spectrometry. A lung tissue
biopsy taken at surgery is also analyzed.

Patients are followed at 60-90 days and then annually for 2-5 years.

PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study within 2 years.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Clinically suspicious stage I (T1-2, N0, M0) lung lesion

- No metastatic disease in the liver or adrenal glands by helical CT scan

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Other

- No malignancy within the past 5 years except effectively treated basal cell or
squamous cell skin cancer, surgically treated carcinoma in situ of the cervix, or
surgically treated lobular carcinoma in situ of the ipsilateral or contralateral
breast AND at low risk for recurrence

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- No prior chemotherapy

Endocrine therapy

- Not specified

Radiotherapy

- No prior radiotherapy

Surgery

- More than 30 days since other prior lung resection

Other

- More than 60 days since prior blood product transfusion

Type of Study:

Interventional

Study Design:

Primary Purpose: Diagnostic

Principal Investigator

David H. Harpole, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Duke Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000350123

NCT ID:

NCT00077324

Start Date:

February 2004

Completion Date:

Related Keywords:

  • Lung Cancer
  • stage I non-small cell lung cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location

Roswell Park Cancer InstituteBuffalo, New York  14263
George Washington University Medical CenterWashington, District of Columbia  20037
Mayo Clinic Cancer CenterRochester, Minnesota  55905
Duke Comprehensive Cancer CenterDurham, North Carolina  27710
CCOP - Upstate CarolinaSpartanburg, South Carolina  29303
Vanderbilt-Ingram Cancer CenterNashville, Tennessee  37232-6838
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
University of Alabama at Birmingham Comprehensive Cancer CenterBirmingham, Alabama  35294-3300
Veterans Affairs Medical Center - DaytonDayton, Ohio  45428
CCOP - DaytonKettering, Ohio  45429
LDS HospitalSalt Lake City, Utah  84143
Siteman Cancer Center at Barnes-Jewish HospitalSaint Louis, Missouri  63110
Charles M. Barrett Cancer Center at University HospitalCincinnati, Ohio  45267-0526
Sutter Cancer CenterSacramento, California  95816
Veterans Affairs Medical Center - PittsburghPittsburgh, Pennsylvania  15240
Veterans Affairs Medical Center - MinneapolisMinneapolis, Minnesota  55417
City of Hope Comprehensive Cancer CenterDuarte, California  91010
Southern Illinois University School of MedicineSpringfield, Illinois  62794-9658
Hillman Cancer Center at University of Pittsburgh Cancer InstitutePittsburgh, Pennsylvania  15236
Swedish Cancer Institute at Swedish Medical Center - First Hill CampusSeattle, Washington  98104
McDowell Cancer Center at Akron General Medical CenterAkron, Ohio  44307
Winship Cancer Institute of Emory UniversityAtlanta, Georgia  30322
Stony Brook University Cancer CenterStony Brook, New York  11794-8174
SUNY Upstate Medical University HospitalSyracuse, New York  13210
Rhode Island Hospital Comprehensive Cancer CenterProvidence, Rhode Island  02903
Hollings Cancer Center at Medical University of South CarolinaCharleston, South Carolina  29425
Mary Babb Randolph Cancer Center at West Virginia University HospitalsMorgantown, West Virginia  26506
St. Vincent Hospital Regional Cancer CenterGreen Bay, Wisconsin  54307-3508
St. Mary's Hospital Medical Center - Green BayGreen Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Mary's HospitalGreen Bay, Wisconsin  54303
William Beaumont Hospital - Royal Oak CampusRoyal Oak, Michigan  48073
Veterans Affairs Medical Center - Loma Linda (Pettis)Loma Linda, California  92357
MBCCOP-Medical College of Georgia Cancer CenterAugusta, Georgia  30912-4000
University of Virginia Cancer CenterCharlottesville, Virginia  22908
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicago, Illinois  60611
Rosenfeld Cancer Center at Abington Memorial HospitalAbington, Pennsylvania  19001
Fox Chase Cancer Center - PhiladelphiaPhiladelphia, Pennsylvania  19111-2497
Sutter Cancer Center at Roseville Medical CenterRoseville, California  95661
John Muir/Mt. Diablo Comprehensive Cancer CenterWalnut Creek, California  94598
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross HospitalFort Lauderdale, Florida  33308
St. Francis Hospital and Health Centers - Beech Grove CampusBeech Grove, Indiana  46107
Reid Hospital & Health Care Services, IncorporatedRichmond, Indiana  47374
Fox Chase Cancer Center at St. Francis Medical CenterTrenton, New Jersey  08629
Samaritan North Cancer Care CenterDayton, Ohio  45415
Grandview HospitalDayton, Ohio  45405
Good Samaritan HospitalDayton, Ohio  45406
Charles F. Kettering Memorial HospitalKettering, Ohio  45429
Middletown Regional HospitalMiddletown, Ohio  45044
UVMC Cancer Care Center at Upper Valley Medical CenterTroy, Ohio  45373-1300
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXenia, Ohio  45385
Lankenau Cancer Center at Lankenau HospitalWynnewood, Pennsylvania  19096
Green Bay Oncology, Limited at St. Vincent HospitalGreen Bay, Wisconsin  54301-3526
Altru Cancer Center at Altru HospitalGrand Forks, North Dakota  58201
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania HospitalPittsburgh, Pennsylvania  15224-1791
Praxair Cancer Center at Danbury HospitalDanbury, Connecticut  06810
Greater Baltimore Medical Center Cancer CenterBaltimore, Maryland  21204
Regional Cancer Center at Memorial Medical CenterSpringfield, Illinois  62781-0001
Jewish HospitalLouisville, Kentucky  40202-1886
Benedictine HospitalKingston, New York  12401
Rutherford HospitalRutherfordton, North Carolina  28139
Bethesda North HospitalCincinnati, Ohio  45242
Cancer Treatment Center at Good Samaritan HospitalCincinnati, Ohio  45220
AnMed Health Cancer CenterAnderson, South Carolina  29621
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Miriam HospitalProvidence, Rhode Island  02906
Cancer Institute at St. John's HospitalSpringfield, Illinois  62701
Glendale Memorial Hospital Comprehensive Cancer CenterGlendale, California  91204
U.T. Cancer Institute at University of Tennessee Medical CenterKnoxville, Tennessee  37920-2911
South Nassau Communities HospitalOceanside, New York  11572
Jameson Memorial Hospital - North CampusNew Castle, Pennsylvania  16105
John Muir/Mount Diablo Cancer Center - Concord CampusConcord, California  94524-4110