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A Phase III Randomized Open-Label Study Comparing Gemcitabine Plus Cetuximab (IMC-C225) Versus Gemcitabine As First-Line Therapy Of Patients With Advanced Pancreas Cancer

Phase 3
18 Years
Not Enrolling
Pancreatic Cancer

Thank you

Trial Information

A Phase III Randomized Open-Label Study Comparing Gemcitabine Plus Cetuximab (IMC-C225) Versus Gemcitabine As First-Line Therapy Of Patients With Advanced Pancreas Cancer


- Compare the overall survival of patients with locally advanced unresectable or
metastatic adenocarcinoma of the pancreas treated with gemcitabine and cetuximab vs
gemcitabine alone.

- Compare the time to treatment failure in patients treated with these regimens.

- Estimate the percentage of patients with epidermal growth factor receptor (EGFR) tumor
expression in patients treated with these regimens.

- Compare the overall survival of patients in the EGFR-positive subset treated with these

- Compare the toxicity of these regimens in these patients.

- Compare the total response rate (confirmed and unconfirmed complete and partial
response) in patients with measurable disease treated with these regimens.

- Compare the patient report of pain and quality of life of patients treated with these

OUTLINE: This is an open-label, randomized, multicenter study. Patients are stratified
according to disease status (locally advanced unresectable vs metastatic), Zubrod
performance status (0 or 1 vs 2), and prior pancreatectomy (yes vs no). Patients are
randomized to 1 of 2 treatment arms.

- Arm I: Patients receive cetuximab IV over 1-2 hours on days 1, 8, 15, and 22 and
gemcitabine IV over 30 minutes on days 1, 8, 15, and 22 for course 1 and days 1, 8, and
15 for all subsequent courses.

- Arm II: Patients receive gemcitabine as in arm I. In both arms, courses repeat every 4
weeks in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed at baseline, before each course, and at the end of study

Patients are followed every 6 months for 2 years and then annually for 1 year.

PROJECTED ACCRUAL: A total of 704 patients (352 per treatment arm) will be accrued for this
study within 5 years.

Inclusion Criteria


- Histologically* or cytologically confirmed pancreatic adenocarcinoma meeting 1 of the
following criteria:

- Locally advanced unresectable disease

- Distant metastatic disease NOTE: If diagnosis is based on a metastatic site the
histology must be compatible with pancreatic cancer

- Measurable or nonmeasurable disease by x-ray, scan, or physical examination

- Tumor tissue must be submitted for evaluation of epidermal growth factor receptor
expression before study entry

- None of the following tumor types are allowed:

- Endocrine tumors

- Lymphoma of the pancreas

- Ampullary cancer

- No known brain metastases



- Not specified

Performance status

- Zubrod 0-2

Life expectancy

- At least 3 months


- Absolute granulocyte count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3


- Bilirubin no greater than 2.0 times upper limit of normal (ULN)

- SGOT or SGPT no greater than 2.5 times ULN


- Creatinine no greater than 2.0 mg/dL


- No significant history of cardiac disease

- No uncontrolled hypertension

- No unstable angina

- No uncontrolled arrhythmia

- No congestive heart failure


- Not pregnant or nursing

- Fertile patients must use effective contraception

- HIV negative

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated
stage I or II cancer that is currently in remission


Biologic therapy

- No prior immunotherapy for advanced pancreatic cancer

- No prior cetuximab or other therapy that targets the epidermal growth factor pathway

- No prior chimerized or murine monoclonal antibody therapy

- No other concurrent anticancer immunotherapy


- At least 6 months since prior adjuvant chemotherapy

- No prior chemotherapy or chemoradiotherapy for advanced pancreatic cancer

- No prior gemcitabine

- No other concurrent anticancer chemotherapy

Endocrine therapy

- No prior hormonal therapy for advanced pancreatic cancer

- No concurrent anticancer hormonal therapy


- See Chemotherapy

- At least 28 days since prior radiotherapy and recovered

- Prior palliative radiotherapy to metastatic sites allowed

- No concurrent anticancer radiotherapy, including whole brain radiotherapy for
progressive disease (i.e., CNS metastasis)


- At least 14 days since prior pancreatic cancer surgery and recovered


- No other concurrent anticancer therapy

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Overall survival comparison between treatment groups

Outcome Time Frame:

every 4 weeks for 3 years

Safety Issue:


Principal Investigator

Philip A. Philip, MD, PhD, FRCP

Investigator Role:

Study Chair

Investigator Affiliation:

Barbara Ann Karmanos Cancer Institute


United States: Federal Government

Study ID:




Start Date:

January 2004

Completion Date:

April 2009

Related Keywords:

  • Pancreatic Cancer
  • adenocarcinoma of the pancreas
  • stage III pancreatic cancer
  • stage IV pancreatic cancer
  • Pancreatic Neoplasms



Akron City Hospital Akron, Ohio  44304
Roswell Park Cancer Institute Buffalo, New York  14263
Fred Hutchinson Cancer Research Center Seattle, Washington  98109
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan  48109-0752
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201
University of Mississippi Medical Center Jackson, Mississippi  39216-4505
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CCOP - North Shore University Hospital Manhasset, New York  11030
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CCOP - Metro-Minnesota Saint Louis Park, Minnesota  55416
Rush-Copley Cancer Care Center Aurora, Illinois  60507
Hinsdale Hematology Oncology Associates Hinsdale, Illinois  60521
Carle Cancer Center at Carle Foundation Hospital Urbana, Illinois  61801
Saint Anthony Memorial Health Centers Michigan City, Indiana  46360
Cedar Rapids Oncology Associates Cedar Rapids, Iowa  52403
Mercy Medical Center - Sioux City Sioux City, Iowa  51104
St. Luke's Regional Medical Center Sioux City, Iowa  51104
Bronson Methodist Hospital Kalamazoo, Michigan  49007
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Borgess Medical Center Kalamazooaa, Michigan  49001
Fairview Ridges Hospital Burnsville, Minnesota  55337
Mercy and Unity Cancer Center at Mercy Hospital Coon Rapids, Minnesota  55433
Fairview Southdale Hospital Edina, Minnesota  55435
Mercy and Unity Cancer Center at Unity Hospital Fridley, Minnesota  55432
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
St. Rita's Medical Center Lima, Ohio  45801
Medical X-Ray Center, PC Sioux Falls, South Dakota  57105
Avera Cancer Institute Sioux Falls, South Dakota  57105
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center La Crosse, Wisconsin  54601
Sutter Health Western Division Cancer Research Group Greenbrae, California  94904
CCOP - Bay Area Tumor Institute Oakland, California  94609-3305
Halifax Medical Center Daytona Beach, Florida  32114
Methodist Medical Center of Illinois Peoria, Illinois  61636
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Veterans Affairs Medical Center - Dayton Dayton, Ohio  45428
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Reading Hospital and Medical Center Reading, Pennsylvania  19612-6052
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Harrington Cancer Center Amarillo, Texas  79106
LDS Hospital Salt Lake City, Utah  84143
Green Mountain Oncology Group Rutland, Vermont  05701
CCOP - Western Regional, Arizona Phoenix, Arizona  85006-2726
University of Colorado Cancer Center at University of Colorado Health Sciences Center Denver, Colorado  80010
CCOP - Grand Rapids Grand Rapids, Michigan  49503
Keesler Medical Center - Keesler Air Force Base Keesler AFB, Mississippi  39534-2576
Charles M. Barrett Cancer Center at University Hospital Cincinnati, Ohio  45267-0526
CCOP - Columbia River Oncology Program Portland, Oregon  97225
MultiCare Regional Cancer Center at Tacoma General Hospital Tacoma, Washington  98405
Cleveland Clinic Taussig Cancer Center Cleveland, Ohio  44195
Veterans Affairs Medical Center - Denver Denver, Colorado  80220
CCOP - St. Louis-Cape Girardeau Saint Louis, Missouri  63141
Brooke Army Medical Center Fort Sam Houston, Texas  78234-6200
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MidMichigan Medical Center - Midland Midland, Michigan  48670
University of California Davis Cancer Center Sacramento, California  95817
University of New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico  87131
City of Hope Comprehensive Cancer Center Duarte, California  91010
Mobile Infirmary Medical Center Mobile, Alabama  36640-0460
Medical Center of Central Georgia Macon, Georgia  31201
St. Vincent Mercy Medical Center Toledo, Ohio  43608
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas  66160-7353
Cancer Research Center at Boston Medical Center Boston, Massachusetts  02118
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Thompson Cancer Survival Center Knoxville, Tennessee  37916
Cancer Care at Our Lady of Bellefonte Hospital Ashland, Kentucky  41101
Hulston Cancer Center at Cox Medical Center South Springfield, Missouri  65807
St. John's Regional Health Center Springfield, Missouri  65804
McDowell Cancer Center at Akron General Medical Center Akron, Ohio  44307
Sioux Valley Hospital and University of South Dakota Medical Center Sioux Falls, South Dakota  57117-5134
M.D. Anderson Cancer Center at University of Texas Houston, Texas  77030
Central Baptist Hospital Lexington, Kentucky  40503
CCOP - Toledo Community Hospital Toledo, Ohio  43623-3456
St. Luke's Hospital Cancer Center Bethlehem, Pennsylvania  18015
Wilford Hall Medical Center Lackland Air Force Base, Texas  78236-5300
Long Island Jewish Medical Center New Hyde Park, New York  11040
Loma Linda University Cancer Institute at Loma Linda University Medical Center Loma Linda, California  92354
Broward General Medical Center Cancer Center Ft. Lauderdale, Florida  33316
University of Florida Shands Cancer Center Gainesville, Florida  32610-0232
Florida Hospital Cancer Institute at Florida Hospital Orlando Orlando, Florida  32803-1273
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center Savannah, Georgia  31403-3089
St. Luke's Mountain States Tumor Institute - Boise Boise, Idaho  83712-6297
Via Christi Cancer Center at Via Christi Regional Medical Center Wichita, Kansas  67214
Spectrum Health Cancer Care - Butterworth Campus Grand Rapids, Michigan  49503-2560
Mission Hospitals - Memorial Campus Asheville, North Carolina  28801
Presbyterian Cancer Center at Presbyterian Hospital Charlotte, North Carolina  28233-3549
Toledo Hospital Toledo, Ohio  43606
Tod Children's Hospital - Forum Health Youngstown, Ohio  44501
Hollings Cancer Center at Medical University of South Carolina Charleston, South Carolina  29425
Baylor University Medical Center - Houston Houston, Texas  77030-2399
Providence Cancer Center at Sacred Heart Medical Center Spokane, Washington  99220-2555
CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York  13057
Sibley Memorial Hospital Washington, District of Columbia  20016
Hematology Oncology Associates of the Quad Cities Bettendorf, Iowa  52722
Alaska Regional Hospital Cancer Center Anchorage, Alaska  99508
Banner Good Samaritan Medical Center Phoenix, Arizona  85006
Banner Thunderbird Medical Center Phoenix, Arizona  85306
North Colorado Medical Center Greeley, Colorado  80631
McKee Medical Center Loveland, Colorado  80539
Saint Anthony's Hospital at Saint Anthony's Health Center Alton, Illinois  62002
Good Samaritan Regional Health Center Mt. Vernon, Illinois  62864
Siouxland Regional Cancer Center Sioux City, Iowa  51101-1733
Cancer Center of Kansas, P.A. - El Dorado El Dorado, Kansas  67042
Southwest Medical Center Liberal, Kansas  67901
Cancer Center of Kansas, P.A. - Parsons Parsons, Kansas  67357
Cancer Center of Kansas, P.A. - Wichita Wichita, Kansas  67214
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Metropolitan Hospital Grand Rapids, Michigan  49506
Lacks Cancer Center at Saint Mary's Mercy Medical Center Grand Rapids, Michigan  49503
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Hackley Hospital Muskegon, Michigan  49443
Northern Michigan Hospital Petoskey, Michigan  49770
William Beaumont Hospital - Royal Oak Campus Royal Oak, Michigan  48073
Munson Medical Center Traverse City, Michigan  49684
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital Gape Girardeau, Missouri  63701
David C. Pratt Cancer Center at St. John's Mercy St. Louis, Missouri  63141
Northern Rockies Radiation Oncology Center Billings, Montana  59101
Hematology-Oncology Centers of the Northern Rockies - Billings Billings, Montana  59101
St. Vincent Healthcare Billings, Montana  59101
Deaconess Billings Clinic - Downtown Billings, Montana  59101
Deaconess Billings Clinic Cancer Center Billings, Montana  59107
Internal Medicine Associates of Bozeman Bozeman, Montana  59715
Bozeman Deaconess Hospital Bozeman, Montana  59715
St. James Community Hospital Butte, Montana  59701
Big Sky Oncology Great Falls, Montana  59405
Sletten Regional Cancer Institute Great Falls, Montana  59405
St. Peter's Hospital Helena, Montana  59601
Kalispell Medical Oncology Kalispell, Montana  59901
Kalispell Regional Medical Center Kalispell, Montana  59901
Glacier Oncology, PLLC Kalispell, Montana  59901
Eastern Montana Cancer Center Miles City, Montana  59301
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center Missoula, Montana  59802
Montana Cancer Specialists at Montana Cancer Center Missoula, Montana  59802
Community Medical Center Missoula, Montana  59801
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Adena Regional Medical Center Chillicothe, Ohio  54601
Doctors Hospital at Ohio Health Columbus, Ohio  43228
Riverside Methodist Hospital Cancer Care Columbus, Ohio  43214
Grant Riverside Cancer Services Columbus, Ohio  43215
Mount Carmel West Hospital Columbus, Ohio  43222
Grady Memorial Hospital Delaware, Ohio  43015
Fairfield Medical Center Lancaster, Ohio  43130
Strecker Cancer Center at Marietta Memorial Hospital Marietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark, Ohio  43055
Community Hospital of Springfield and Clark County Springfield, Ohio  45505
Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital Westerville, Ohio  43081
Genesis - Good Samaritan Hospital Zanesville, Ohio  43701
American Fork Hospital American Fork, Utah  84003
Logan Regional Hospital Logan, Utah  84321
Cottonwood Hospital Medical Center Murray, Utah  84107
McKay-Dee Hospital Center Ogden, Utah  84403
Utah Cancer Specialists at UCS Cancer Center Salt Lake City, Utah  84106
St. Joseph Hospital Community Cancer Center Bellingham, Washington  98225
Olympic Hematology and Oncology Bremerton, Washington  98310
Skagit Valley Hospital Cancer Care Center Mt. Vernon, Washington  98273
University Cancer Center at University of Washington Medical Center Seattle, Washington  98195
Harborview Medical Center Seattle, Washington  98104
Group Health Central Hospital Seattle, Washington  98104
North Puget Oncology at United General Hospital Sedro-Wooley, Washington  98284
Cancer Care Northwest - Spokane South Spokane, Washington  99202
Wenatchee Valley Clinic Wenatchee, Washington  98801
Lenoir Memorial Cancer Center Kinston, North Carolina  28503-1678
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center Washington, District of Columbia  20007
Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois  61602
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center Orange, California  92868
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Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois  62526
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights, Ohio  44124
Front Range Cancer Specialists Fort Collins, Colorado  80528
Jennersville Regional Hospital West Grove, Pennsylvania  19390-9499
Fox Valley Hematology and Oncology - East Grant Street Appleton, Wisconsin  54911-3496
Alta Bates Comprehensive Cancer Center Berkeley, California  94704
Peninsula Medical Center Burlingame, California  94010
Mount Diablo Regional Cancer Center Concord, California  94524-4110
Marin Cancer Institute at Marin General Hospital Greenbrae, California  94904
Saint Rose Hospital Hayward, California  94545
Highland General Hospital at St. George's University School of Medicine Oakland, California  94602
Valley Care Medical Center Pleasanton, California  94588
California Pacific Medical Center - California Campus San Francisco, California  94118
J.C. Robinson, M.D. Regional Cancer Center San Pablo, California  94806
Sutter Solano Medical Center Vallejo, California  94589
John Muir/Mt. Diablo Comprehensive Cancer Center Walnut Creek, California  94598
Memorial Hospital Colorado Springs, Colorado  80909
Poudre Valley Hospital Fort Collins, Colorado  80524
St. Joseph Medical Center Bloomington, Illinois  61701
Graham Hospital Canton, Illinois  61520
Memorial Hospital Carthage, Illinois  62321
Eureka Community Hospital Eureka, Illinois  61530
Galesburg Cottage Hospital Galesburg, Illinois  61401
Galesburg Clinic Galesburg, Illinois  61401
InterCommunity Cancer Center of Western Illinois Galesburg, Illinois  61401
Mason District Hospital Havana, Illinois  62644
Hopedale Medical Complex Hopedale, Illinois  61747
Kewanee Hospital Kewanee, Illinois  61443
McDonough District Hospital Macomb, Illinois  61455
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Perry Memorial Hospital Princeton, Illinois  61356
St. Margaret's Hospital Spring Valley, Illinois  61362
Valley Cancer Center Spring Valley, Illinois  61362
St. Francis Hospital and Health Centers - Beech Grove Campus Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Fort Wayne, Indiana  46815
Reid Hospital & Health Care Services, Incorporated Richmond, Indiana  47374
McFarland Clinic, P. C. Ames, Iowa  50010
St. Luke's Hospital Cedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Genesis Medical Center - West Campus Davenport, Iowa  52804
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
Cancer Center of Kansas, P.A. - Chanute Chanute, Kansas  66720
Cancer Center of Kansas, P.A. - Kingman Kingman, Kansas  67068
Cancer Center of Kansas, P.A. - Newton Newton, Kansas  67114
Cancer Center of Kansas, P.A. - Pratt Pratt, Kansas  67124
Cancer Center of Kansas, P.A. - Salina Salina, Kansas  67042
Stormont-Vail Cancer Center Topeka, Kansas  66604
St. Francis Comprehensive Cancer Center Topeka, Kansas  66606
Cancer Center of Kansas, P.A. - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, P.A. - Medical Arts Tower Wichita, Kansas  67208
Associates in Womens Health, P.A. - North Review Wichita, Kansas  67203
Cancer Center of Kansas, P.A. - Winfield Winfield, Kansas  67156
Sturdy Memorial Hospital Attleboro, Massachusetts  02703
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
Mecosta County Medical Center Big Rapids, Michigan  49307
Haematology-Oncology Associates of Ohio and Michigan, P.C. Lambertville, Michigan  48144
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Community Cancer Center of Monroe Monroe, Michigan  48162
Mercy Memorial Hospital System Monroe, Michigan  48162
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
Park Nicollet Health Services St. Louis Park, Minnesota  55416
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Adirondack Cancer Care - Glens Falls Glens Falls, New York  12801
Wayne Radiation Oncology Goldsboro, North Carolina  27534
Iredell Memorial Hospital Statesville, North Carolina  28677
Wilson Medical Center Wilson, North Carolina  27893-3428
Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem, North Carolina  27103
Wood County Oncology Center Bowling Green, Ohio  43402
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
Good Samaritan Hospital Dayton, Ohio  45406
Blanchard Valley Medical Associates Findlay, Ohio  45840
Fremont Memorial Hospital Fremont, Ohio  43420
Community Oncology Group at Cleveland Clinic Cancer Center Independence, Ohio  44131
Kenton Oncology, Incorporated Kenton, Ohio  43326
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
Toledo Clinic - Oregon Oregon, Ohio  43616
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Firelands Regional Medical Center Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Promedica Cancer Center at Flower Hospital Sylvania, Ohio  43560
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
Toledo Surgical Specialists Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Fulton County Health Center Wauseon, Ohio  43567
Cleveland Clinic - Wooster Wooster, Ohio  44691
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center Portland, Oregon  97210
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Kingsport, Tennessee  37662
UMC Southwest Cancer and Research Center Lubbock, Texas  79415-3364
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Southwestern Vermont Regional Cancer Center Bennington, Vermont  05201
Danville Regional Medical Center Danville, Virginia  24541
Southwest Virginia Regional Cancer Center Norton, Virginia  24273
Providence Cancer Center at Holy Family Hospital Spokane, Washington  99207
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
Welch Cancer Center at Sheridan Memorial Hospital Sheridan, Wyoming  82801
Montrose Memorial Hospital Cancer Center Montrose, Colorado  81401
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
Joliet Oncology Hematology Associates, Limited - West Joliet, Illinois  60435
Oncology Hematology Associates of Central Illinois - Ottawa Ottawa, Illinois  61350
Rose Ramer Cancer Clinic at Anderson Area Medical Center Anderson, South Carolina  29621
St. Francis Hospital Federal Way, Washington  98003
St. Clare Hospital Lakewood, Washington  98499-0998
Capital Medical Center Olympia, Washington  98502
Providence St. Peter Hospital Regional Cancer Center Olympia, Washington  98506
Good Samaritan Cancer Center Puyallup, Washington  98371
St. Joseph Medical Center at Franciscan Health System Tacoma, Washington  98405-3004
Allenmore Hospital Tacoma, Washington  98411-0414
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Ft. Smith, Arkansas  72903
California Cancer Center - Woodward Park Office Fresno, California  93720
Northeast Georgia Medical Center Gainesville, Georgia  30501
Pearlman Comprehensive Cancer Center at South Georgia Medical Center Valdosta, Georgia  31603
Central Maine Medical Center Lewiston, Maine  04240
Randolph Hospital Asheboro, North Carolina  27203
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital Eden, North Carolina  27288
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
University Hospitals Ireland Cancer Center at Mercy Medical Center Canton, Ohio  44708
Huron Hospital Cancer Care Center Cleveland, Ohio  44112
Euclid Hospital Cleveland, Ohio  44119
Medical College of Ohio Cancer Institute Toledo, Ohio  43614
South Pointe Hospital Cancer Care Center Warrensville Heights, Ohio  44122
Institute of Oncology at Vilnius University Portland, Oregon  97227
Salem Hospital Regional Cancer Center Salem, Oregon  97309
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Midelfort Clinic - Luther Eau Claire, Wisconsin  54702
Praxair Cancer Center at Danbury Hospital Danbury, Connecticut  06810
Carl and Dorothy Bennett Cancer Center at Stamford Hospital Stamford, Connecticut  06904
West Florida Cancer Institute at West Florida Hospital - Pensacola Pensacola, Florida  32514
Covenant Cancer Treatment Center Waterloo, Iowa  50702
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Medical Consultants, Limited Milwaukee, Wisconsin  53215
Methodist Cancer Center at Methodist Hospital - Omaha Omaha, Nebraska  68114
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Auburn Regional Center for Cancer Care Auburn, Washington  98002
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital Whittier, California  90602
Caritas Norwood Hospital Norwood, Massachusetts  02062
Seacoast Cancer Center at Wentworth-Douglass Hospital Dover, New Hampshire  03820
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Rutherford Hospital Rutherfordton, North Carolina  28139
Easton Regional Cancer Center at Easton Hospital Easton, Pennsylvania  18042
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Martha Jefferson Hospital Cancer Care Center Charlottesville, Virginia  22901
Good Samaritan Health Systems Kearney, Nebraska  68847
Sherman Hospital Elgin, Illinois  60120-2198
Cancer Treatment Center at Christus Schumpert St. Mary Place Shreveport, Louisiana  71101
McLeod Regional Medical Center Florence, South Carolina  29501
Presbyterian Hospital of Dallas Dallas, Texas  75231
St. Joseph Mercy Hospital Pontiac, Michigan  48341-2985
Highlands Oncology Group - Springdale Springdale, Arkansas  72764
La Grange Memorial Hospital La Grange, Illinois  60525
St. Charles Medical Center - Bend Bend, Oregon  97701
Roper St. Francis Cancer Center at Roper Hospital Charleston, South Carolina  29401
Rockwood Clinic Cancer Treatment Center Spokane, Washington  99204-2967
Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center Boca Raton, Florida  33486
Florida Oncology Associates Orange Park, Florida  32073
Cancer Center of Kansas, P.A. - Dodge City Dodge City, Kansas  67801
Mercy General Hospital Sacramento, California  95819
Caritas St. Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Valley Hospital - Ridgewood Ridgewood, New Jersey  07450
Faxton Regional Cancer Center Utica, New York  13502
St. Joseph's Hospital Health Center - Syracuse Syracuse, New York  13203
John B. Amos Community Cancer Center Columbus, Georgia  31902
St. Anthony's Cancer Center St. Louis, Missouri  63128
Medical and Surgical Specialists, L L C Galesburg, Illinois  61401
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields Olympia Fields, Illinois  60461
Siouxland Hematology-Oncology Associates at June E. Nylen Cancer Center Sioux City, Iowa  51101
United States Air Force Medical Center Wright-Patterson Wright-Patterson Afb, Ohio  45433-5529
Providence Centralia Hospital Regional Cancer Center Centralia, Washington  98531
New York Oncology Hematology, P.C. Albany, New York  12208
Heartland Oncology & Hematology Council Bluffs, Iowa  51503
Ottumwa Regional Health Center Cancer Center Ottumwa, Iowa  52501
All Saints Cancer Center at All Saints Medical Center Racine, Wisconsin  53405
Luther Midlelfort Hospital Eau Claire, Wisconsin  54702
East Alabama Medical Center Opelika, Alabama  36801-5452
Cancer Center at Providence Alaska Medical Center Anchorage, Alaska  99519-6604
Virginia K. Crosson Cancer Center at St. Jude Medical Center Fullerton, California  92835
Delnor Community Hospital - Geneva Geneva, Illinois  60134
Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue Waterloo, Iowa  50702
Mount Carmel Regional Cancer Center Pittsburg, Kansas  66762
Caritas Holy Family Hospital Methuen, Massachusetts  01844
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center Dubois, Pennsylvania  15801
Vince Lombardi Cancer Center - Elkhorn Elkhorn, Wisconsin  53121
Mercy Hospital Portland, Maine  04101
Cancer Center of Boston - Chestnut Hill Boston, Massachusetts  02120
San Juan Regional Cancer Center Farmington, New Mexico  87401-5631
New York Oncology Hematology, PC - Albany Albany, New York  12208
Center for Cancer Medicine and Blood Disorders, PA El Paso, Texas  79902
United Hospital Center Clarksburg, West Virginia  26301