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A Phase II Study of Triapine (NSC 663249) in Previously Untreated Patients With Recurrent Renal Cell Carcinoma


Phase 2
18 Years
N/A
Not Enrolling
Both
Kidney Cancer

Thank you

Trial Information

A Phase II Study of Triapine (NSC 663249) in Previously Untreated Patients With Recurrent Renal Cell Carcinoma


OBJECTIVES:

Primary

- Determine the efficacy of 3-AP (Triapine®), in terms of objective response rate, in
patients with previously untreated locally recurrent or metastatic renal cell
carcinoma.

Secondary

- Determine the adverse events and tolerability of this drug in these patients.

- Determine the time to disease progression and overall survival of patients treated with
this drug.

OUTLINE: This is a nonrandomized, multicenter study.

Patients receive 3-AP (Triapine®) IV over 2 hours on days 1-4 and 15-18. Treatment repeats
every 28 days for up to 6 courses (for stable patients) in the absence of disease
progression or unacceptable toxicity. Patients who achieve a complete response (CR) receive
1 additional course after documentation of CR. Patients who achieve a partial response (PR)
receive 2 additional courses after documentation of stable PR.

Patients are followed every 4 weeks until relapse and then every 3 months for up to 2 years.

PROJECTED ACCRUAL: A total of 15-30 patients will be accrued for this study within 1 year.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed renal cell carcinoma

- Locally recurrent OR metastatic disease

- Incurable by standard therapy

- Clinically and/or radiologically measurable disease

- At least 1 unidimensionally measurable lesion* at least 20 mm by x-ray, physical
exam, or non-spiral CT scan OR at least 10 mm by spiral CT scan

- If the sole site of measurable disease is in a previously irradiated field,
there must be documented disease progression at that site NOTE: *Bone lesions
are not considered measurable disease

- No documented brain metastases

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- ECOG 0-2

Life expectancy

- Not specified

Hematopoietic

- Absolute granulocyte count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

- No glucose-6-phosphate dehydrogenase (G6PD) deficiency* NOTE: *Screening for G6PD
deficiency is required for patients of African, Asian, or Mediterranean descent

Hepatic

- Bilirubin normal

- AST or ALT no greater than 2.5 times upper limit of normal (ULN)

Renal

- Creatinine no greater than 1.5 times ULN

- Creatinine clearance at least 50 mL/min

Cardiovascular

- No myocardial infarction within the past 6 months

- No symptomatic congestive heart failure

- No unstable angina

- No active cardiomyopathy

- No cardiac arrhythmia

- No uncontrolled hypertension

Pulmonary

- No pulmonary disease requiring oxygen

Immunologic

- HIV negative

- No known hypersensitivity to compounds of similar chemical or biological composition
to 3-AP (Triapine®)

- No active uncontrolled or serious infection

- No immunodeficiency

Other

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No other prior malignancy except adequately treated nonmelanoma skin cancer,
curatively treated carcinoma in situ of the cervix, or other curatively treated solid
tumor with no evidence of disease for at least 5 years

- No history of significant neurologic or psychiatric disorder (e.g., uncontrolled
psychotic disorders) that would preclude giving informed consent or complying with
study requirements

- No active peptic ulcer disease

- No other serious illness or medical condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

- More than 3 months since prior interferon for advanced or recurrent disease

- No other prior immunotherapy for advanced or recurrent disease

- No prior gene therapy

Chemotherapy

- No prior systemic chemotherapy for advanced or recurrent disease

Endocrine therapy

- Not specified

Radiotherapy

- See Disease Characteristics

- At least 4 weeks since prior radiotherapy (except low-dose nonmyelosuppressive
radiotherapy) and recovered

Surgery

- At least 2 weeks since prior major surgery

Other

- No prior investigational anticancer agents

- No other concurrent anticancer agents or therapy

- No other concurrent investigational therapy

- No concurrent anticoagulants

- Concurrent nontherapeutic warfarin or heparin allowed

Type of Study:

Interventional

Study Design:

Masking: Open Label, Primary Purpose: Treatment

Principal Investigator

Jennifer Knox, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Toronto General Hospital

Authority:

United States: Federal Government

Study ID:

I161

NCT ID:

NCT00075660

Start Date:

January 2004

Completion Date:

September 2008

Related Keywords:

  • Kidney Cancer
  • recurrent renal cell cancer
  • stage III renal cell cancer
  • stage IV renal cell cancer
  • Carcinoma
  • Carcinoma, Renal Cell
  • Kidney Neoplasms

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