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A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma

Phase 3
18 Years
Open (Enrolling)
Kidney Cancer

Thank you

Trial Information

A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma



- Compare the overall survival of patients with advanced renal cell carcinoma treated
with interferon alfa-2b alone or interferon alfa-2b with bevacizumab.


- Compare the time to disease progression and objective response rates in patients
treated with these regimens.

- Determine the toxicity of interferon alfa-2b in combination with bevacizumab in these

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to prior
nephrectomy (yes vs no) and number of risk factors for disease progression (0 vs 1-2 vs 3 or
more). Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients receive interferon alfa-2b subcutaneously (SC) three times a week.

- Arm II: Patients receive interferon alfa-2b as in arm I and bevacizumab IV over 30-90
minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

Patients are followed every 3 months for 2 years and then annually for up to 10 years after
study entry.

PROJECTED ACCRUAL: A total of 700 patients (350 per treatment arm) will be accrued for this
study within 3 years.

Inclusion Criteria


- Histologically or cytologically confirmed renal cell carcinoma (RCC)

- Conventional clear cell carcinoma

- Metastatic or unresectable disease

- The following characteristics and cellular types are excluded:

- True papillary

- Sarcomatoid features without a clear cell component

- Chromophobe

- Oncocytoma

- Collecting duct tumor

- Transitional cell carcinoma

- Measurable or nonmeasurable disease, including any of the following:

- Unidimensionally measurable lesion ≥ 20 mm by conventional techniques (e.g.,
physical exam or chest x-ray) OR 10 mm by spiral CT scan or MRI

- The following are considered nonmeasurable disease:

- Small lesions

- Bone lesions

- Leptomeningeal disease

- Ascites

- Pleural/pericardial effusion

- Lymphangitis cutis/pulmonis

- Abdominal masses that are not confirmed and followed by imaging techniques

- Cystic lesions

- Irradiated lesions, unless progression is documented after radiotherapy

- RCC paraffin tissue blocks or unstained slides must be available

- No evidence of prior or concurrent CNS metastases by MRI or CT scan



- 18 and over

Performance status

- Karnofsky 70-100%

Life expectancy

- Not specified


- Granulocyte count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- No history of clinically significant bleeding


- AST/ALT ≤ 2.5 times upper limit of normal (ULN)

- Alkaline phosphatase ≤ 2.5 times ULN

- Bilirubin ≤ 1.5 times ULN


- Creatinine ≤ 1.5 times ULN

- No proteinuria > 1+

- Proteinuria ≥ 2+ allowed provided protein is < 2 g/24-hour urine collection


- No deep venous thrombosis within the past year

- No cerebrovascular accident within the past year

- No peripheral vascular disease with claudication on < 1 block

- No uncontrolled hypertension defined as blood pressure ≥160 mm Hg (systolic) and/or ≥
90 mm Hg (diastolic) while on medication

- No New York Heart Association class II-IV congestive heart failure

- No angina pectoris requiring nitrate therapy

- No myocardial infarction within the past 6 months

- No other significant cardiovascular disease


- No pulmonary embolus within the past year

- No ongoing hemoptysis


- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 3 months after study

- No preexisting thyroid abnormality in which normal thyroid function cannot be
maintained by medication

- No delayed wound healing, ulcers, or bone fractures

- No uncontrolled psychiatric disorder

- No other currently active* malignancy except nonmelanoma skin cancer NOTE: *Disease
is not considered currently active if patient completed anticancer therapy and is
considered to have < 30% risk of relapse


Biologic therapy

- No prior systemic immunotherapy for RCC

- No prior thalidomide, anti-vascular endothelial growth factor (VEGF) therapy, VEGF
receptor inhibitors, or antiangiogenic treatment of any kind

- No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)


- No prior systemic chemotherapy for RCC

- No concurrent chemotherapy

Endocrine therapy

- No concurrent systemic corticosteroid therapy except the following:

- Topical and inhaled steroids

- Replacement therapy for adrenal insufficiency

- No concurrent hormones except those administered for nondisease-related conditions
(e.g., insulin for diabetes)


- See Disease Characteristics

- At least 4 weeks since prior radiotherapy and recovered

- Prior palliative radiotherapy to metastatic lesions allowed provided at least 1
measurable or nonmeasurable lesion remains untreated

- No concurrent palliative radiotherapy


- At least 4 weeks since prior major surgery and recovered


- No other prior systemic investigational therapy for RCC

- No other prior adjuvant or neoadjuvant systemic therapy for RCC

- No concurrent full-dose oral or parenteral anticoagulation* NOTE: *Low-dose (1 mg)
warfarin for maintenance of catheter patency and/or daily prophylactic aspirin is

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Overall Survival

Outcome Time Frame:

5 years

Safety Issue:


Principal Investigator

Brian I. Rini, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of California, San Francisco


United States: Food and Drug Administration

Study ID:




Start Date:

October 2003

Completion Date:

July 2015

Related Keywords:

  • Kidney Cancer
  • stage IV renal cell cancer
  • clear cell renal cell carcinoma
  • recurrent renal cell cancer
  • Carcinoma
  • Carcinoma, Renal Cell
  • Kidney Neoplasms



Roswell Park Cancer InstituteBuffalo, New York  14263
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Walter Reed Army Medical CenterWashington, District of Columbia  20307-5000
Emory University Hospital - AtlantaAtlanta, Georgia  30322
University of Chicago Cancer Research CenterChicago, Illinois  60637
Duke Comprehensive Cancer CenterDurham, North Carolina  27710
Abington Memorial HospitalAbington, Pennsylvania  19001
CCOP - Upstate CarolinaSpartanburg, South Carolina  29303
CCOP - WichitaWichita, Kansas  67214-3882
Rhode Island HospitalProvidence, Rhode Island  02903
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Bergan Mercy Medical CenterOmaha, Nebraska  68124
Yale Comprehensive Cancer CenterNew Haven, Connecticut  06520-8028
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Carle Cancer Center at Carle Foundation HospitalUrbana, Illinois  61801
Saint Anthony Memorial Health CentersMichigan City, Indiana  46360
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Mercy Medical Center - Sioux CitySioux City, Iowa  51104
St. Luke's Regional Medical CenterSioux City, Iowa  51104
CCOP - Michigan Cancer Research ConsortiumAnn Arbor, Michigan  48106
Genesys Hurley Cancer InstituteFlint, Michigan  48503
Foote HospitalJackson, Michigan  49201
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Seton Cancer Institute - SaginawSaginaw, Michigan  48601
St. John Macomb HospitalWarren, Michigan  48093
Fairview Ridges HospitalBurnsville, Minnesota  55337
Fairview Southdale HospitalEdina, Minnesota  55435
Hutchinson Area Health CareHutchinson, Minnesota  55350
Meeker County Memorial HospitalLichfield, Minnesota  55355
Hennepin County Medical Center - MinneapolisMinneapolis, Minnesota  55415
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Ridgeview Medical CenterWaconia, Minnesota  55387
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St. Rita's Medical CenterLima, Ohio  45801
Natalie Warren Bryant Cancer Center at St. Francis HospitalTulsa, Oklahoma  74136
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
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Marshfield Clinic - Marshfield CenterMarshfield, Wisconsin  54449
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Memorial Hospital Cancer CenterColorado Springs, Colorado  80909
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Mercy Hospital Cancer Center - ScrantonScranton, Pennsylvania  18501
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UMASS Memorial Cancer Center - University CampusWorcester, Massachusetts  01605-2982
CCOP - Grand RapidsGrand Rapids, Michigan  49503
Ellis Fischel Cancer Center at University of Missouri - ColumbiaColumbia, Missouri  65203
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire  03756-0002
Cancer Institute of New Jersey at the Cooper University HospitalCamden, New Jersey  08103-1489
Long Island Cancer Center at Stony Brook University HospitalStony Brook, New York  11790-7775
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel HillChapel Hill, North Carolina  27599-7570
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Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State UniversityColumbus, Ohio  43210-1240
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CCOP - Scott and White HospitalTemple, Texas  76508
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MBCCOP - LSU Health Sciences CenterNew Orleans, Louisiana  70112
CCOP - St. Louis-Cape GirardeauSaint Louis, Missouri  63141
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Naval Medical Center - San DiegoSan Diego, California  92134-3202
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Veterans Affairs Medical Center - MinneapolisMinneapolis, Minnesota  55417
Rebecca and John Moores UCSD Cancer CenterLa Jolla, California  92093-0658
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Veterans Affairs Medical Center - San DiegoSan Diego, California  92161
UCSF Comprehensive Cancer CenterSan Francisco, California  94115
Fort Wayne Medical Oncology and Hematology, IncorporatedFort Wayne, Indiana  46885-5099
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John Stoddard Cancer Center at Iowa Methodist Medical CenterDes Moines, Iowa  50309
Midlands Cancer Center at Midlands Community HospitalPapillion, Nebraska  68128-4157
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Medical Center of Central GeorgiaMacon, Georgia  31201
St. Vincent Mercy Medical CenterToledo, Ohio  43608
CCOP - Colorado Cancer Research Program, IncorporatedDenver, Colorado  80224
Great Falls ClinicGreat Falls, Montana  59405
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Overlook HospitalSummit, New Jersey  07902-0220
Northside Hospital Cancer CenterAtlanta, Georgia  30342-1611
Evanston Northwestern Health Care - Evanston HospitalEvanston, Illinois  60201
Fairview University Medical Center - University CampusMinneapolis, Minnesota  55455
Hulston Cancer Center at Cox Medical Center SouthSpringfield, Missouri  65807
St. John's Regional Health CenterSpringfield, Missouri  65804
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Oklahoma University Medical CenterOklahoma City, Oklahoma  73104
Sioux Valley Hospital and University of South Dakota Medical CenterSioux Falls, South Dakota  57117-5134
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Trinity Cancer Care CenterMinot, North Dakota  58701
CCOP - Toledo Community HospitalToledo, Ohio  43623-3456
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Ochsner Cancer Institute at Ochsner Clinic FoundationNew Orleans, Louisiana  70121
CancerCare of Maine at Eastern Maine Medial CenterBangor, Maine  04401
Spectrum Health Cancer Care - Butterworth CampusGrand Rapids, Michigan  49503-2560
SUNY Upstate Medical University HospitalSyracuse, New York  13210
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Presbyterian Cancer Center at Presbyterian HospitalCharlotte, North Carolina  28233-3549
Toledo HospitalToledo, Ohio  43606
Greenville Hospital System Cancer CenterGreenville, South Carolina  29605
Massey Cancer Center at Virginia Commonwealth UniversityRichmond, Virginia  23298-0037
Providence Cancer Center at Sacred Heart Medical CenterSpokane, Washington  99220-2555
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston DivisionCharleston, West Virginia  25302
Mary Babb Randolph Cancer Center at West Virginia University HospitalsMorgantown, West Virginia  26506
Lahey Clinic Medical Center - BurlingtonBurlington, Massachusetts  01805
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - OmahaOmaha, Nebraska  68114-4199
Aultman Hospital Cancer Center at Aultman Health FoundationCanton, Ohio  44710-1799
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Warren HospitalPhillipsburg, New Jersey  08865
Lewistown HospitalLewistown, Pennsylvania  17044
Mount Nittany Medical CenterState College, Pennsylvania  16803
Oncology Institute of Greater LafayetteLafayette, Indiana  47904
Hematology Oncology Associates of the Quad CitiesBettendorf, Iowa  52722
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Batte Cancer Center at Northeast Medical CenterConcord, North Carolina  28025
Baptist Cancer Institute - JacksonvilleJacksonville, Florida  32207
Saint Anthony's Hospital at Saint Anthony's Health CenterAlton, Illinois  62002
Siouxland Hematology-Oncology AssociatesSioux City, Iowa  51101
Cancer Center of Kansas - ChanuteChanute, Kansas  66720
Cancer Center of Kansas - Dodge CityDodge City, Kansas  67801
Cancer Center of Kansas, P.A. - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas - KingmanKingman, Kansas  67068
Southwest Medical CenterLiberal, Kansas  67901
Cancer Center of Kansas - NewtonNewton, Kansas  67114
Cancer Center of Kansas, P.A. - ParsonsParsons, Kansas  67357
Pratt Cancer Center of KansasPratt, Kansas  67124
Cancer Center of Kansas - SalinaSalina, Kansas  67042
Cancer Center of Kansas - WellingtonWellington, Kansas  67152
Cancer Center of Kansas, P.A.Wichita, Kansas  67208
Associates in Womens HealthWichita, Kansas  67203
Cancer Center of Kansas, P.A. - WichitaWichita, Kansas  67214
Cancer Center of Kansas - WinfieldWinfield, Kansas  67156
Mecosta County General HospitalBig Rapids, Michigan  49307
Metropolitan HospitalGrand Rapids, Michigan  49506
Lacks Cancer Center at Saint Mary's Mercy Medical CenterGrand Rapids, Michigan  49503
Holland Community HospitalHolland, Michigan  49423
Hackley HospitalMuskegon, Michigan  49443
Northern Michigan HospitalPetoskey, Michigan  49770
William Beaumont Hospital - Royal Oak CampusRoyal Oak, Michigan  48073
Munson Medical CenterTraverse City, Michigan  49684
St. Francis Medical CenterCape Girardeau, Missouri  63701
Southeast Missouri Regional Cancer Center at Southeast Missouri HospitalGape Girardeau, Missouri  63701
David C. Pratt Cancer Center at St. John's MercySt. Louis, Missouri  63141
Sletten Regional Cancer InstituteGreat Falls, Montana  59405
Wayne Memorial Hospital, IncorporatedGoldsboro, North Carolina  27534
Adena Regional Medical CenterChillicothe, Ohio  54601
Doctors Hospital at Ohio HealthColumbus, Ohio  43228
Riverside Methodist Hospital Cancer CareColumbus, Ohio  43214
Grant Riverside Cancer ServicesColumbus, Ohio  43215
Mount Carmel West HospitalColumbus, Ohio  43222
Grady Memorial HospitalDelaware, Ohio  43015
Fairfield Medical CenterLancaster, Ohio  43130
Strecker Cancer Center at Marietta Memorial HospitalMarietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial HospitalNewark, Ohio  43055
Community Hospital of Springfield and Clark CountySpringfield, Ohio  45505
Mercy Medical Center Oncology UnitSpringfield, Ohio  45504
Avera McKennan Hospital and University Health CenterSioux Falls, South Dakota  57105
Medical X-Ray CenterSioux Falls, South Dakota  57105
Lombardi Cancer Center at Georgetown University Medical CenterWashington, District of Columbia  20007
Greenebaum Cancer Center at University of Maryland Medical CenterBaltimore, Maryland  21201
UNMC Eppley Cancer Center at the University of Nebraska Medical CenterOmaha, Nebraska  68198-7680
Memorial Cancer Institute at Memorial Regional HospitalHollywood, Florida  33021
Lenoir Memorial Cancer CenterKinston, North Carolina  28503-1678
Miriam Hospital at LifespanProvidence, Rhode Island  02906
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey  08903
Beth Israel Medical Center - Petrie DivisionNew York, New York  10003-3803
Kaiser Permanente Medical Center - SacramentoSacramento, California  95825
MBCCOP-Medical College of Georgia Cancer CenterAugusta, Georgia  30912-4000
Mountain States Tumor Institute - BoiseBoise, Idaho  83712
University of Illinois Medical CenterChicago, Illinois  60612
Dakota Cancer Institute at Innovis Health - Dakota ClinicFargo, North Dakota  58103-4940
Simmons Cancer Center at University of Texas Southwestern Medical Center - DallasDallas, Texas  75390-9063
Medcenter One Health SystemBismarck, North Dakota  58501
Oncology/Hematology Associates of Central Illinois, P.C.Peoria, Illinois  61602
Leo W. Jenkins Cancer Center at Pitt County Memorial HospitalGreenville, North Carolina  27858-4354
Decatur Memorial Hospital Cancer Care InstituteDecatur, Illinois  62526
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
Elkhart General HospitalElkhart, Indiana  46515
Florida Cancer SpecialistsFort Myers, Florida  33901
Front Range Cancer SpecialistsFort Collins, Colorado  80528
Lakeland Regional Cancer Center at Lakeland Regional Medical CenterLakeland, Florida  33805
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Joan Karnell Cancer Center at Pennsylvania HospitalPhiladelphia, Pennsylvania  19107
Kaiser Permanente - FremontFremont, California  94538
Kaiser Permanente Medical Center - HaywardHayward, California  94545
Kaiser Permanente Medical Center - Redwood CityRedwood City, California  94063
Kaiser Permanente Medical Center - RichmondRichmond, California  94801
Kaiser Permanente Medical Center - RosevilleRoseville, California  95661
South Sacramento Kaiser-Permanente Medical CenterSacramento, California  95823
Kaiser Permanente Medical Office -Vandever Medical OfficeSan Diego, California  92120
Kaiser Permanente Medical Center - Santa TeresaSan Jose, California  95119
Kaiser Foundation Hospital - San RafaelSan Rafael, California  94903
Kaiser Permanente Medical Center - Santa RosaSanta Rosa, California  95403
Kaiser Permanente Medical Center - South San FranciscoSouth San Francisco, California  94080
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Kaiser Permanente Medical Center - Walnut CreekWalnut Creek, California  94596
Poudre Valley HospitalFort Collins, Colorado  80524
St. Mary-Corwin Regional Medical CenterPueblo, Colorado  81004
Beebe Medical CenterLewes, Delaware  19958
St. Francis HospitalWilmington, Delaware  19805
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross HospitalFort Lauderdale, Florida  33308
Ella Milbank Foshay Cancer Center at Jupiter Medical CenterJupiter, Florida  33458
Saint Joseph's Hospital of AtlantaAtlanta, Georgia  30342-1701
Piedmont HospitalAtlanta, Georgia  30309
WellStar Cobb HospitalAustell, Georgia  30106
Charles B. Eberhart Cancer Center at DeKalb Medical CenterDecatur, Georgia  30033
Gwinnett Medical CenterLawrenceville, Georgia  30045
Kennestone Cancer Center at Wellstar Kennestone HospitalMarietta, Georgia  30060
Southern Regional Medical CenterRiverdale, Georgia  30274-2600
St. Joseph Medical CenterBloomington, Illinois  61701
Graham HospitalCanton, Illinois  61520
Memorial HospitalCarthage, Illinois  62321
Galesburg Cottage HospitalGalesburg, Illinois  61401
Galesburg ClinicGalesburg, Illinois  61401
InterCommunity Cancer Center of Western IllinoisGalesburg, Illinois  61401
Mason District HospitalHavana, Illinois  62644
Hopedale Medical ComplexHopedale, Illinois  61747
Kewanee HospitalKewanee, Illinois  61443
McDonough District HospitalMacomb, Illinois  61455
Trinity Medical Center - EastMoline, Illinois  61265
BroMenn Regional Medical CenterNormal, Illinois  61761
Community Cancer CenterNormal, Illinois  61761
Community Hospital of OttawaOttawa, Illinois  61350
Cancer Treatment Center at Pekin HospitalPekin, Illinois  61554
OSF St. Francis Medical CenterPeoria, Illinois  61637
Proctor HospitalPeoria, Illinois  61614
Illinois Valley Community HospitalPeru, Illinois  61354
Perry Memorial HospitalPrinceton, Illinois  61356
St. Margaret's HospitalSpring Valley, Illinois  61362
Valley Cancer CenterSpring Valley, Illinois  61362
Center for Cancer Therapy at LaPorte Hospital and Health ServicesLa Porte, Indiana  46350
St. Luke's HospitalCedar Rapids, Iowa  52402
Genesis Regional Cancer Center at Genesis Medical CenterDavenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Mercy Capitol HospitalDes Moines, Iowa  50307
Medical Oncology and Hematology Associates at John Stoddard Cancer CenterDes Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer CenterDes Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Burgess Health CenterOnawa, Iowa  51040
St. Francis Comprehensive Cancer CenterTopeka, Kansas  66606
Ochsner Clinic of Baton RougeBaton Rouge, Louisiana  708169990
Mary Bird Perkins Cancer Center - Baton RougeBaton Rouge, Louisiana  70809
Terrebonne General Medical CenterHouma, Louisiana  70360
Union Hospital Cancer Center at Union HospitalElkton MD, Maryland  21921
Hickman Cancer Center at Bixby Medical CenterAdrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy HospitalAnn Arbor, Michigan  48106-0995
Haematology-Oncology Associates of Ohio and Michigan, P.C.Lambertville, Michigan  48144
Community Cancer Center of MonroeMonroe, Michigan  48162
Mercy Memorial Hospital SystemMonroe, Michigan  48162
MeritCare Clinic - BemidjiBemidji, Minnesota  56601
Brainerd Medical CenterBrainerd, Minnesota  56401
Virginia Piper Cancer Institute at Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Chippewa County - Montevideo HospitalMontevideo, Minnesota  56265
Hubert H. Humphrey Cancer Center at North Memorial Medical CenterRobbinsdale, Minnesota  55422-2900
CentraCare Clinic - River CampusSt. Cloud, Minnesota  56303
Hattiesburg Clinic, P.A.Hattiesburg, Mississippi  39401
Bryan LGH Medical Center WestLincoln, Nebraska  68502
St. Elizabeth Regional Medical CenterLincoln, Nebraska  68510
Great Plains Regional Medical CenterNorth Platte, Nebraska  69101-6598
Kingsbury Center for Cancer Care at Cheshire Medical CenterKeene, New Hampshire  03431
Frisbie Memorial HospitalRochester, New Hampshire  03867
Charles R. Wood Cancer Center at Glens Falls HospitalGlens Falls, New York  12801
Forsyth Regional Cancer Center at Forsyth Medical CenterWinston-Salem, North Carolina  27103
Bismarck Cancer CenterBismarck, North Dakota  58501
MeritCare Medical GroupFargo, North Dakota  58122
Wood County Oncology CenterBowling Green, Ohio  43402
Samaritan North Cancer Care CenterDayton, Ohio  45415
Grandview HospitalDayton, Ohio  45405
Good Samaritan HospitalDayton, Ohio  45406
Blanchard Valley Medical AssociatesFindlay, Ohio  45840
Fremont Memorial HospitalFremont, Ohio  43420
Charles F. Kettering Memorial HospitalKettering, Ohio  45429
Lima Memorial HospitalLima, Ohio  45804
St. Luke's HospitalMaumee, Ohio  43537
Northwest Ohio Oncology CenterMaumee, Ohio  43537
Middletown Regional HospitalMiddletown, Ohio  45044
St. Charles Mercy HospitalOregon, Ohio  43616
North Coast Cancer Care, IncorporatedSandusky, Ohio  44870
Firelands Regional Medical CenterSandusky, Ohio  44870
Promedica Cancer Center at Flower HospitalSylvania, Ohio  43560
Mercy Hospital of TiffinTiffin, Ohio  44883
Toledo Surgical SpecialistsToledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical CenterTroy, Ohio  45373-1300
Fulton County Health CenterWauseon, Ohio  43567
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXenia, Ohio  45385
Comanche County Memorial HospitalLawton, Oklahoma  73505
Kaiser Permanente Health Care - PortlandPortland, Oregon  97232
Hematology and Oncology AssociatesScranton, Pennsylvania  18510
Bon Secours St. Francis Health SystemGreenville, South Carolina  29601
Mountainview MedicalBerlin, Vermont  05602
Danville Regional Medical CenterDanville, Virginia  24541
Virginia Oncology Associates - HamptonHampton, Virginia  23666
Providence Cancer Center at Holy Family HospitalSpokane, Washington  99207
San Francisco General Hospital Medical CenterSan Francisco, California  94110
Eureka HospitalEureka, Illinois  61530
Joliet Oncology Hematology Associates, Limited - WestJoliet, Illinois  60435
Oncology Hematology Associates of Central Illinois - OttawaOttawa, Illinois  61350
Baton Rouge General Regional Cancer CenterBaton Rouge, Louisiana  70821
Cancer Center at Medical Center of Louisiana - New OrleansNew Orleans, Louisiana  70140-1015
Mercy HospitalCoon Rapids, Minnesota  55433
Mercy and Unity Cancer Center at Mercy and Unity HospitalsFridley, Minnesota  55432-2799
Park Nicollet ClinicSt. Louis Park, Minnesota  55416
Rose Ramer Cancer Clinic at Anderson Area Medical CenterAnderson, South Carolina  29621
McFarland Clinic, P.C.Ames, Iowa  50010
Saint Anthony Regional HospitalCarroll, Iowa  51401
St. John's HospitalMaplewood, Minnesota  55109
Fremont Area Medical CenterFremont, Nebraska  68025-2387
Alegent Health - Immanuel Medical CenterOmaha, Nebraska  68122
Mid Dakota Clinic, P.C.Bismarck, North Dakota  58501
Lancaster General HospitalLancaster, Pennsylvania  17604-3555
Pottstown Memorial Regional Cancer CenterPottstown, Pennsylvania  19464
Geisinger Medical GroupState College, Pennsylvania  16801
Geisinger Wyoming Valley Medical CenterWilkes-Barre, Pennsylvania  18711
Fox Valley Hematology and OncologyAppleton, Wisconsin  54911
Oconomowoc Memorial HospitalOconomowoc, Wisconsin  53066
CCOP - Mayo Clinic Scottsdale Oncology ProgramScottsdale, Arizona  85259
Hembree Mercy Cancer Center at St. Edward Mercy Medical CenterFt. Smith, Arkansas  72903
Providence Holy Cross Cancer CenterMission Hills, California  91346-9600
Middlesex Hospital Cancer CenterMiddletown, Connecticut  06457
Northeast Georgia Medical CenterGainesville, Georgia  30501
Swedish American HospitalRockford, Illinois  61104
St. Francis Hospital and Health CentersBeech Grove, Indiana  46107
Saint Joseph Regional Medical Center - Plymouth CampusPlymouth, Indiana  46544
Mercy Cancer Center at Mercy Medical CenterCedar Rapids, Iowa  52403
Alegent Health Mercy HospitalCouncil Bluffs, Iowa  51503
Wendt Regional Cancer Center at Finley HospitalDubuque, Iowa  52001
Alegent Health Community Memorial HospitalMissouri Valley, Iowa  51555
Battle Creek Health SystemBattle Creek, Michigan  49017
Spectrum Health Hospital - Blodgett CampusGrand Rapids, Michigan  49506
Oncology Care Associates, P.L.L.C.Saint Joseph, Michigan  49085
Cancer Care Center at St. Luke's HospitalDuluth, Minnesota  55805
Cancer Care Center at Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Cancer CenterShakopee, Minnesota  55379
St. Joseph's HospitalSt Paul, Minnesota  55102
Adult and Pediatric Urology, P.L.L.P.St. Cloud, Minnesota  56303
Woodwinds HospitalWoodbury, Minnesota  55125
Saint Luke's HospitalChesterfield, Missouri  63017
Missouri Cancer AssociatesColumbia, Missouri  65201
Missouri Baptist Cancer CenterSt. Louis, Missouri  63131
Cancer Center at the Good Samaritan Health SystemsKearney, Nebraska  68847
Cancer Resource Center - LincolnLincoln, Nebraska  68510
Cancer Center at Creighton University Medical CenterOmaha, Nebraska  68131
Washoe Cancer Services at Washoe Medical Center - RenoReno, Nevada  89502
Cancer Center at the Mountainside HospitalMontclair, New Jersey  07042
Hematology-Oncology Associates, PCAlbuquerque, New Mexico  87106
Lovelace Medical Center at Lovelace Sandia Health SystemAlbuquerque, New Mexico  87108
Louis Busch Hager Cancer Center at Mary Imogene Bassett HospitalCooperstown, New York  13326
Randolph HospitalAsheboro, North Carolina  27203
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial HospitalEden, North Carolina  27288
Moses Cone Regional Cancer Center at Wesley Long Community HospitalGreensboro, North Carolina  27401
Annie Penn Cancer CenterReidsville, North Carolina  27320
Akron City Hospital at Summa Health SystemAkron, Ohio  44304
University Hospitals Ireland Cancer Center at Mercy Medical CenterCanton, Ohio  44708
Miami Valley HospitalDayton, Ohio  45409
Medical College of Ohio Cancer InstituteToledo, Ohio  43614
Toledo Clinic, IncorporatedToledo, Ohio  43623
John and Dorothy Morgan Cancer Center at Lehigh Valley HospitalAllentown, Pennsylvania  18105
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania HospitalPittsburgh, Pennsylvania  15224-1791
Guthrie Medical Center - SayreSayre, Pennsylvania  18840
All Saints Cancer Center at All Saints HealthcareRacine, Wisconsin  53405
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311
Vince Lombardi Cancer Clinic - SheboyganSheboygan, Wisconsin  53081
St. Francis Medical CenterHonolulu, Hawaii  96817
Regional Cancer Center at Memorial Medical CenterSpringfield, Illinois  62781-0001
Watson ClinicLakeland, Florida  33805
St. Joseph Hospital Regional Cancer Center - OrangeOrange, California  92868-3849
Phoebe Cancer Center at Phoebe Putney Memorial HospitalAlbany, Georgia  31702
Comprehensive Cancer Center at Our Lady of Mercy Medical CenterBronx, New York  10466
Queen's Cancer Institute at Queen's Medical CenterHonolulu, Hawaii  96813
Pardee Memorial HospitalHendersonville, North Carolina  28791
Rutherford HospitalRutherfordton, North Carolina  28139
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
MedCentral - Mansfield HospitalMansfield, Ohio  44903
Cancer Care and Research Pavilion at St. Joseph's/CandlerSavannah, Georgia  31405-6013
Freeman Cancer Institute at Freeman Health SystemJoplin, Missouri  64803-2644
New Mexico Cancer Care AssociatesSanta Fe, New Mexico  87505-7670
Mercy Health CenterOklahoma City, Oklahoma  73120
Central Pennsylvania Hematology and Medical Oncology Associates, PCLemoyne, Pennsylvania  17043
Palm Beach Cancer Institute - West Palm BeachWest Palm Beach, Florida  33401
Huntsville HospitalHuntsville, Alabama  35807
La Grange Memorial HospitalLa Grange, Illinois  60525
PinnacleHealth Regional Cancer Center at Polyclinic HospitalHarrisburg, Pennsylvania  17105
Florida Oncology AssociatesOrange Park, Florida  32073
Lipson Cancer and Blood Center at Rochester General HospitalRochester, New York  14621
Marshall University Medical CenterHuntington, West Virginia  25701
Rappahannock General HospitalKilmarnock, Virginia  22482
South Carolina Oncology AssociatesColumbia, South Carolina  29201
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
Kapiolani Medical Center for Women and ChildrenHonolulu, Hawaii  96826
Straub Clinic and Hospital, IncorporatedHonolulu, Hawaii  96813
OnCare Hawaii, Incorporated - KuakiniHonolulu, Hawaii  96817
OnCare Hawaii, Incorporated - LusitanaHonolulu, Hawaii  96813
Iowa Blood and Cancer CareCedar Rapids, Iowa  52402
Faxton Regional Cancer CenterUtica, New York  13502
St. Joseph's Hospital Health Center - SyracuseSyracuse, New York  13203
Alexian Brothers Cancer Care CenterElk Grove Village, Illinois  60007
Arroyo Grande Community HospitalArroyo Grande, California  93420
Lynn Regional Cancer Center of Boca Raton Community HospitalBoca Raton, Florida  33486
Hematology and Oncology of Northeast GeorgiaAthens, Georgia  30607
John B. Amos Community Cancer CenterColumbus, Georgia  31902
Provena St. Mary's Wasser Regional Cancer Center - KankakeeKankakee, Illinois  60901
St. Anthony's Cancer CenterSt. Louis, Missouri  63128
St. Elizabeth Boardman Cancer CenterBoardman, Ohio  44512
St. Joseph Health Care CenterWarren, Ohio  44484
St. Elizabeth Cancer Center at St. Elizabeth Health Center - YoungstownYoungstown, Ohio  44510
UW Health OncologyMadison, Wisconsin  53715
University of Wisconsin Cancer Center at Aspirus Wausau HospitalWausau, Wisconsin  54401
Hematology Oncology Consultants Ltd.Naperville, Illinois  60540
United States Air Force Medical Center Wright-PattersonWright-Patterson Afb, Ohio  45433-5529
Washington Hematology - Oncology SpecialistsYakima, Washington  98902
North Star Lodge Cancer CenterYakima, Washington  98902
Comprehensive Cancer Center at Gaston MemorialGastonia, North Carolina  28053-1747
Kent General Hospital at Bayhealth Medical CenterDover, Delaware  19901
Augusta Oncology AssociatesAugusta, Georgia  30901
Toledo ClinicOregon, Ohio  43616
Baptist Hospital of East TennesseeKnoxville, Tennessee  37920
Hematology & Oncology ClinicHattiesburg, Mississippi  39402
Cancer Center at Ottumwa Regional Health CenterOttumwa, Iowa  52501
Shands Cancer Center at the University of Florida - JacksonvilleGainesville, Florida  32610
Holy Family Memorial Medical CenterManitowoc, Wisconsin  54221
Cancer Center at Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Arlington Cancer Center - ArlingtonArlington, Texas  76012
Mount Carmel Regional Cancer CenterPittsburg, Kansas  66762
Union State Bank Cancer Center at Nyack HospitalNyack, New York  10960-1998
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer CenterDubois, Pennsylvania  15801
Florida Hospital - OrlandoOrlando, Florida  32803
Medical ConsultantsMilwaukee, Wisconsin  53215-3690
Norwalk HospitalNorwalk, Connecticut  06856
Cancer Center of Colorado SpringsColorado Springs, Colorado  80907
Medical and Surgical Specialists, LLCGalesburg, Illinois  61401
Commonwealth Hematology-Oncology P.C. - QuincyQuincy, Massachusetts  02169
St. Luke's-Roosevelt Hospital Center - St.Luke's DivisionNew York, New York  10025
Kenton Oncology, Inc.Kenton, Ohio  43326
Jones ClinicGermantown, Tennessee  38138
Vince Lombardi Cancer Center - ElkhornElkhorn, Wisconsin  53121
Oncology Alliance, S.C. - Milwaukee - EastGlendale, Wisconsin  53212
Froedtert Hospital and Medical College of WisconcinMilwaukee, Wisconsin  53226-3596