Inclusion Criteria

- INCLUSION CRITERIA:

Normal volunteers, age greater than or equal to 18 years of Caucasian or Chinese ancestry
will be eligible for the study. Chinese ancestry will be defined as being born in China
(including Taiwan, Hong Kong and Singapore) or being first generation offspring of parents
born in China (including Taiwan, Hong Kong and Singapore).

ECOG performance status of 0 or 1.

Individuals must weigh at least 110 pounds.

Potential participants must pass the criteria for blood donors established by the American
Association of Blood Banks according to the routine screening performed within the
Department of Transfusion Medicine.

Potential participants should pass a brief physical exam to exclude potential cardiac
problems.

WBC 3000/mm(3) or greater.

Platelet count 90,000 mm(3) or greater.

Negative pregnancy test

Ante-cubital veins compatible with the apheresis process. Apheresis center nurses will
assess the ante-cubital veins of all subjects prior to enrollment. If their veins are
judged to be too small to support the intravenous catheter required for the procedure,
they will be excluded. If at the time of each apheresis procedure the nurses are unable
to obtain adequate ante-cubital vein access, the subject will be excluded.

Evidence of previous exposure to EBV infection will not represent inclusion criteria.

EXCLUSION CRITERIA:

Potential participants will be excluded:

Who are undergoing or have undergone in the past 3 weeks any form of systemic therapy that
may affect immune function.

Who have active systemic infections, autoimmune disease or any known immunodeficiency
disease.

Who require systemic steroid therapy.

Who are pregnant.

Who are positive for hepatitis B (s)AG or HIV antibody (because of possible immune effects
of these conditions). HIV testing will be performed prior to enrollment.

Who have any form of active primary or secondary immune deficiency.