A Comparative Study of Pediatric CNS Tumor Activity as Assessed by F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (H-MRSI)
- Children with brain tumors are generally followed for response or progression by
imaging studies, such as CT or MRI.
- While these imaging studies help delineate the anatomical location and extent of a
tumor within the CNS, they give no information regarding the biologic or metabolic
activity of the lesion.
- Proton Nuclear Magnetic Resonance Spectroscopic Imaging ((1)H-MRSI) is a non-invasive
method of detecting and measuring cellular metabolites in vivo, providing biochemical
information in conjunction with the spatial information obtained by MRI.
- Positron Emission Tomography (PET) is a technique that also provides data on metabolic
activity of brain lesions.
- A comparison of these two methods in determining a lesion's metabolic activity has not
been reported in children with brain tumors.
- To compare biologic or metabolic activity of brain tumors in pediatric patients as
determined by (1)H-MRSI and [(18)F-]-FDG PET scanning
- To correlate results of (1)H-MRSI and (18)F-FDG PET imaging with outcome.
- To use [(18)F-]-FDG PET, (1)H-MRSI and various MR sequences to evaluate changes over
time in primary brain tumors as a result of the natural history of the lesion or
- Age: greater than or equal to 1 year and less than to 21 years
- Patients must have a brain tumor that is measurable or evaluable on standard MRI or CT.
- Patients referred for this study will have both (1)H-MRSI and (18)F-FDG PET imaging
performed within 2 weeks of each other at the NCI
- Patients will remain on study for 5 years or until one of the off-study criteria have
been met (whichever occurs first)
Single timepoint comparison as assessed by fludeoxyglucose F 189FDG) positron emission tomography (PET) vs nuclear magnetic resonance spectroscopy (NMRS).
Katherine E Warren, M.D.
National Cancer Institute (NCI)
United States: Federal Government
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