Characterization of Serum Proteomic Patterns in Neoplastic and Inflammatory Skin Disease
- Determine whether computer-assisted, higher-order analysis of participant low molecular
weight serum proteins can detect distinctive proteomic patterns in participants with
normal skin vs mycosis fungoides/cutaneous T-cell lymphoma vs psoriasis.
- Determine whether these proteomic patterns can distinguish between various stages of
cutaneous T-cell lymphoma.
OUTLINE: This is a pilot study.
Participants complete a general and skin health questionnaire and undergo a whole-body skin
examination. Blood samples are taken and analyzed for low molecular weight serum proteins by
PROJECTED ACCRUAL: A total of 141-423 participants (47-94 each of healthy volunteers,
psoriasis patients, and T3 cutaneous T-cell lymphoma patients and 141 T1, T2, and T4 mycosis
fungoides patients) will be accrued for this study within 3 years.
Primary Purpose: Diagnostic
Mark C. Udey, MD, PhD
NCI - Dermatology Branch
United States: Federal Government
|University of Michigan Comprehensive Cancer Center||Ann Arbor, Michigan 48109-0752|
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||Baltimore, Maryland 21231-2410|
|Stanford Cancer Center||Stanford, California 94305-5824|
|Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office||Bethesda, Maryland 20892-1182|