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The Natural History of Childhood Malignancies Treated With Radiation Therapy


N/A
N/A
21 Years
Open (Enrolling)
Both
Neoplasms

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Trial Information

The Natural History of Childhood Malignancies Treated With Radiation Therapy


BACKGROUND

-Children with cancer represent relatively rare disorders that are of unique scientific
importance and educational value.

OBJECTIVES

-This protocol will allow follow-up of these patients for determination of the effects of
radiation on overall survival, as well as relapse-free/ disease-free survival, local
control, and the late sequelae of radiation therapy.

ELIGIBILITY

-Children with cancer and who require radiation are referred to the Radiation Oncology
Branch primarily from Children's National Medical Center in Washington, D.C. and from other
Branches of the NCI/NIH.

DESIGN

-This protocol is designed to provide the radiation component of therapy in children with
cancer that have diseases that are of unique scientific interests, importance, and/or
educational value.

Inclusion Criteria


- INCLUSION CRITERIA:

Patients who are evaluated by the Radiation Oncology Branch and are:

Children with cancer (or a precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes), between the age(s) of 6 months - 21 years, whose cancer (or
precancer syndrome) will be treated with radiation therapy in the Radiation Oncology
Branch, NCI.

Patients with cancer (or a precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes), who present with disease manifestations of special interest to
Radiation Oncology Branch investigators, because they are likely to shed led light on the
natural history, pathogenesis, radiation response, and late effects of disease process.

Patients with cancer (or precancer syndromes, such as aplastic anemia or other
myelodysplastic syndromes) who offer an important educational benefit to trainees in
radiation oncology and staff.

Patient must have a primary physician in the community who specializes in pediatrics
and/or oncology and is willing to collaborate with the ROB staff in the clinical
management of the patient

If indicated, availability of a parent or legal guardian to give informed consent

Children with cancer (or a precancer syndrome, such as aplastic anemia or other
myelodysplastic syndrome), between the age(s) of 6 months - 21 years, whose cancer (or
precancer syndrome) have already been treated with radiation therapy in the Radiation
Oncology Branch, NCI.

EXCLUSION CRITERIA:

Patients, and/or guardians who are in the estimation of the PI, deemed unable or unlikely
to adhere to protocol treatment and follow-up requirements.

Patients who are enrolled on a clinical trial (e.g. COG or CNMC) in which one of the
research objectives is to study the radiation treatment.

Patients who are pregnant and are to receive radiation treatment on this protocol.

Type of Study:

Observational

Study Design:

N/A

Principal Investigator

Kevin A Camphausen, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)

Authority:

United States: Federal Government

Study ID:

030241

NCT ID:

NCT00064883

Start Date:

July 2003

Completion Date:

Related Keywords:

  • Neoplasms
  • Radiation
  • Children
  • Cancer
  • Late Effects
  • Natural History
  • Neoplasms

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892