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Evaluation and Treatment of Neurosurgical Disorders

4 Years
Open (Enrolling)
Neurologic Disorders

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Trial Information

Evaluation and Treatment of Neurosurgical Disorders

Objective: This protocol is designed to allow evaluation of patients with a variety of
neurosurgical disorders for purposes of providing standard expert care and physician

Study Population: Patients 4 years of age and older with neurosurgical-related conditions
are eligible for this protocol. The investigators will select patients based on the most
appropriate needs for purposes of SNB and NINDS training.

Study Design: This is an observational study for training. Patients will receive standard
evaluation and treatment for their condition. A physician, physician assistant, or nurse
practitioner will obtain a medical history and perform a physical and neurological
examination. Clinical evaluation may include laboratory and radiological studies designed to
aid in diagnosis or differential diagnosis of the patient's condition or to facilitate
treatment. The evaluations may take place in the outpatient clinic areas or in the
inpatient units. Some patients will receive standard-of-care medical or surgical treatment
for their disorder. Tissue or blood samples removed during standard treatment, if not needed
for care of the patient, may be used for research.

Outcome Measures: No additional research outcome measures will be tracked in this study.
All outcomes will be those of standard clinical evaluation and treatment.

Inclusion Criteria


1. Age 4 and older.

2. Neurosurgical-related conditions such as brain tumors, pituitary tumors,
epilepsy, Parkinson's disease, other abnormal movement disorders, arteriovenous
malformations, and pain disorders, based on Surgical Neurology Branch training
and teaching needs.

3. For adults: able to provide informed consent or having a legally-authorized
representative to provide consent, if incapacitated.

For minors: a parent or legal guardian who is able to provide consent.


1.Medically unstable or severe organ failure based on clinical evaluation

Type of Study:


Study Design:


Principal Investigator

John D Heiss, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Institute of Neurological Disorders and Stroke (NINDS)


United States: Federal Government

Study ID:




Start Date:

May 2003

Completion Date:

Related Keywords:

  • Neurologic Disorders
  • Brain Tumor
  • Epilepsy
  • Pituitary Adenoma
  • Parkinson's Disease
  • Vascular Malformation
  • Neurosurgery
  • Glioblastoma
  • Astrocytoma
  • Oligodendroglioma
  • Spinal Arteriovenous Malformation
  • Oncogenes
  • Proteomics
  • Nervous System Diseases



National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland  20892