Subject

Inclusion Criteria:

- History of histologically confirmed colorectal adenocarcinoma metastatic to the liver
with no clinical or radiographic evidence of extrahepatic disease. Confirmation of
diagnosis must be performed at MSKCC.

- Potentially completely resectable hepatic metastases without current evidence of
other metastatic disease.

- Abdominal and pelvic CT scans and chest CT or x-ray within 6 weeks prior to
registration. (MRI of abdomen may be substituted for CT of abdomen.)

- Lab values within 14 days prior to registration:

- WBC ≥ 3.0 K/ul

- ANC >1.5 K/ul

- Platelets ≥ 100 K/ul

- Total bilirubin ≤ 1.5 mg/dl.

- Prior chemotherapy is acceptable if last dose given ≥ 3 weeks prior to registration
to this study.

- KPS ≥ 60%

- Signed informed consent.

Subject Exclusion Criteria:

- Prior radiation to the liver. (Prior radiation therapy to the pelvis is acceptable if
completed at least 4 weeks prior to registration.)

- Active infection, ascites, hepatic encephalopathy

- Prior oxaliplatin or cisplatin or HAI FUDR

- Female patients who are pregnant or lactating