Inclusion Criteria:

- Patients must have histologically confirmed supratentorial grade IV astrocytoma
(glioblastoma multiforme)

- Patients must not have received prior radiation therapy, chemotherapy, hormonal
therapy, immunotherapy or therapy with biologic agents (including immunotoxins
immunoconjugates, antisense, peptide receptor antagonists, interferons, interleukins,
TIL, LAK or gene therapy) or hormonal therapy for their brain tumor; glucocorticoid
therapy is allowed

- Patients must have measurable and contrast-enhancing tumor on the post operative,
pretreatment MRI/CT scan (within two weeks of starting treatment)

- Patients must have recovered from the immediate post-operative period and be
maintained on a stable corticosteroid regimen from the time of their baseline scan
until the start of treatment

- Patients must have a Karnofsky performance status >= 60% (i.e. the patient must be
able to care for himself/herself with occasional help from others)

- Absolute neutrophil count >= 1500/mm^3

- Platelets >= 100,000/mm^3

- Hemoglobin >= 9 g/dl

- Creatinine =< 1.5 mg/dl

- Total bilirubin =< 2.0 mg/dl

- Transaminases =< 4 times above the upper limits of the institutional norm

- Patients must be able to provide written informed consent and must be aware of the
investigational nature of this study

- Patients with the potential for pregnancy or impregnating their partner must agree to
follow acceptable birth control methods to avoid conception; the anti-proliferative
activity of this experimental drug may be harmful to the developing fetus or nursing
infant; female patients of child-bearing potential must have a negative pregnancy
test

- Patients must have no concurrent malignancy except curatively treated basal or
squamous cell carcinoma of the skin or carcinoma in situ of the cervix and breast;
patients with prior malignancies must be disease-free for >= five years

- Patients must have a mini-mental state exam score (MMSE) of >= 15

Exclusion Criteria:

- Patients with serious concurrent infection or medical illness which would jeopardize
the ability of the patient to receive the chemotherapy outlined in this protocol with
reasonable safety

- Patients who are pregnant or breast-feeding

- Patients who have received prior radiation therapy, chemotherapy, hormonal therapy
(except glucocorticoids), immunotherapy or therapy with biologic agents (including
immunotoxins, immunoconjugates, antisense, peptide receptor antagonists, interferons,
interleukins, TIL, LAK or gene therapy) for their brain tumor

- Patients receiving concurrent investigational agents

- Patients who have received Gliadel wafer therapy may not participate in this study