MRI Evaluation Of The Contralateral Breast In Women With Recent Diagnosis Of Breast Cancer
- Determine the diagnostic yield of magnetic resonance imaging (MRI) in evaluating the
contralateral breast of women with a recent unilateral diagnosis of breast cancer and a
negative contralateral mammogram and clinical breast exam.
- Determine the sensitivity, specificity, positive predictive value for both call backs
for additional imaging and biopsy recommendations, and receiver operating
characteristic curves of MRI in evaluating these patients.
- Determine the effect of the following patient-related factors: age (50 years old and
over vs less than 50 years old), breast parenchymal density (fatty vs non fatty
breast), and tumor histology (invasive lobular vs invasive ductal, invasive vs in situ)
on the performance of MRI (cancer yield, sensitivity, specificity, and PPV).
OUTLINE: This is a multicenter study.
Patients receive gadopentetate dimeglumine IV and then undergo magnetic resonance imaging of
the contralateral breast.
Patients are followed at 12-18 and 24-30 months.
PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study.
Primary Purpose: Diagnostic
Constance Lehman, MD, PhD
Seattle Cancer Care Alliance
United States: Federal Government
|Jonsson Comprehensive Cancer Center, UCLA||Los Angeles, California 90095-1781|
|Walter Reed Army Medical Center||Washington, District of Columbia 20307-5000|
|Porter Adventist Hospital||Denver, Colorado 80210|
|Cancer Center at the University of Virginia||Charlottesville, Virginia 22908|
|Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill||Chapel Hill, North Carolina 27599-7570|
|Charles M. Barrett Cancer Center at University Hospital||Cincinnati, Ohio 45267-0526|
|Kimmel Cancer Center at Thomas Jefferson University - Philadelphia||Philadelphia, Pennsylvania 19107|
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||Baltimore, Maryland 21231-2410|
|Hartford Hospital||Hartford, Connecticut 06102-5037|
|Allegheny General Hospital||Pittsburgh, Pennsylvania 15212-4772|
|UCSF Comprehensive Cancer Center||San Francisco, California 94115|
|Arkansas Cancer Research Center at University of Arkansas for Medical Sciences||Little Rock, Arkansas 72205|
|Mayo Clinic||Jacksonville, Florida 32224|
|Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas||Dallas, Texas 75390-9063|
|Abramson Cancer Center at University of Pennsylvania Medical Center||Philadelphia, Pennsylvania 19104|
|Robert H. Lurie Comprehensive Cancer Center at Northwestern University||Chicago, Illinois 60611|
|Seattle Cancer Care Alliance||Seattle, Washington 98109|
|Memorial Medical Center||Springfield, Illinois 62781|
|Boca Raton Community Hospital||Boca Raton, Florida 33486|