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A Clinical Trial Comparing Anastrozole With Tamoxifen in Postmenopausal Patients With Ductal Carcinoma in Situ (DCIS) Undergoing Lumpectomy With Radiation Therapy

Phase 3
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

A Clinical Trial Comparing Anastrozole With Tamoxifen in Postmenopausal Patients With Ductal Carcinoma in Situ (DCIS) Undergoing Lumpectomy With Radiation Therapy


- Compare the value of anastrozole vs tamoxifen, in terms of preventing recurrence (i.e.,
local, regional, and distant recurrences and contralateral breast cancer), after
lumpectomy and radiotherapy in postmenopausal women with ductal carcinoma in situ

- Compare subsequent disease occurrence, in terms of invasive breast cancer (local,
regional, distant, or contralateral), ipsilateral and contralateral breast cancer
(invasive and DCIS), and non-breast second primary malignancies, in patients treated
with these drugs.

- Compare quality of life and symptoms of patients treated with these drugs.*

- Compare quality-adjusted survival time of patients treated with these drugs.*

- Compare the occurrence of osteoporotic fractures in patients treated with these drugs.

- Compare disease-free and overall survival of patients treated with these drugs. NOTE:
*The quality of life study closed to accrual as of 12/28/04.

OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients
are stratified according to age (under 60 vs 60 and over). Patients are randomized to 1 of 2
treatment arms (arm I and arm II closed to accrual as of 6/15/06).

- Arm I (closed to accrual as of 6/15/06): Patients receive oral tamoxifen and oral
placebo once daily for 5 years.

- Arm II (closed to accrual as of 6/15/06): Patients receive oral anastrozole and oral
placebo once daily for 5 years.

Beginning within 8 weeks of randomization, all patients also undergo whole breast
radiotherapy, unless the patient is enrolled in protocol NSABP-B-39 and randomized to the
partial breast irradiation group.

Patients are followed every 6 months for 5 years, and then annually thereafter.

For patients enrolled in the quality of life study, quality of life is assessed at baseline
and then every 6 months for 6 years.*

NOTE: *The quality of life study closed to accrual as of 12/28/04.

PROJECTED ACCRUAL: A total of 3,000 patients (1,500 per treatment arm) will be accrued for
this study within 5 years (arm I and arm II closed to accrual as of 6/15/06).

Inclusion Criteria


- Histologically confirmed ductal carcinoma in situ (DCIS) of the breast

- Mixed DCIS and lobular carcinoma in situ (LCIS) allowed

- Must have undergone lumpectomy

- Margins must be histologically free of disease

- Re-excision to obtain tumor-free margins allowed

- No more than 84 days since prior lumpectomy or re-excision

- More than 1 area of DCIS allowed provided all disease is removed with tumor-free

- Masses or clusters of calcification that are clinically or mammographically
suspicious must be biopsied

- No prior invasive breast cancer or DCIS

- Patients with a history of LCIS are eligible

- No prior or concurrent invasive (including microinvasive) breast cancer

- DCIS "suspicious" for microinvasion allowed

- No bilateral malignancy

- No mass or mammographic abnormality suspicious for malignancy in the opposite
breast unless not malignant as proven by biopsy

- No Paget's disease of the nipple

- No positive ipsilateral axillary or intramammary nodes

- No palpable nodes in the ipsilateral or contralateral axilla or palpable
supraclavicular or infraclavicular nodes unless not involved with tumor as
proven by biopsy

- Hormone receptor status:

- Estrogen- or progesterone-receptor positive as determined by

- Borderline results are considered positive



- See Menopausal status


- Female

Menopausal status:

- Postmenopausal as defined by at least 1 of the following:

- Prior documented bilateral oophorectomy

- At least 12 months without spontaneous bleeding

- Age 55 or over with prior hysterectomy without oophorectomy

- Age 54 or under with prior hysterectomy without oophorectomy with a documented
follicle-stimulating hormone level in the postmenopausal range

Performance status

- Zubrod 0-2

Life expectancy

- At least 10 years (excluding diagnosis of breast cancer)


- WBC normal


- AST normal

- Bilirubin normal

- Alkaline phosphatase normal

- No hepatic disease that would preclude administration of study drugs


- Creatinine normal

- No renal disease that would preclude administration of study drugs


- No prior documented cerebral vascular accident or transient ischemic attack

- No prior deep vein thrombosis

- No cardiovascular disease that would preclude administration of study drugs

- No uncontrolled hypertension (i.e., systolic blood pressure at least 180 mm Hg or
diastolic blood pressure at least 110 mm Hg based on the average of 2 or more
readings at each of 2 or more visits after initial screening)

- No uncontrolled atrial fibrillation


- No pulmonary embolus


- Not pregnant or nursing

- Patients with a history of non-breast malignancies are eligible provided they have
been disease-free for ≥ 5 years and are deemed by their physician to be at low risk
for recurrence

- No other malignancy within the past 5 years except treated basal cell or squamous
cell skin cancer, carcinoma in situ of the cervix, carcinoma in situ of the colon, or
melanoma in situ

- No psychiatric or addictive disorders that would preclude informed consent

- No uncontrolled diabetes, defined as hemoglobin A1C greater than 9% (fasting glucose
200 mg/dL)

- No nonmalignant systemic disease that would preclude administration of study drugs


Endocrine therapy

- No prior or concurrent aromatase inhibitors (e.g., exemestane or letrozole) or

- No concurrent raloxifene or other selective estrogen receptor modulators

- No concurrent sex hormone therapy (e.g., estrogen or progesterone replacement
therapy, oral contraceptives, androgens, luteinizing hormone releasing hormone
analogs, prolactin inhibitors, or antiandrogens)

- Low-dose estrogen vaginal creams or Estring allowed


- Radiotherapy for this cancer initiated before study is allowed


- See Disease Characteristics

- No prior or concurrent mastectomy for DCIS

- Prior sentinel node biopsy or axillary node dissection allowed provided nodes are
pathologically negative


- No concurrent warfarin

- No other systemic therapy for this cancer initiated before study

- No other concurrent anticancer therapy unless permitted by the protocol investigator

- No concurrent participation in another clinical trial of therapy for DCIS

- Concurrent participation in protocol NSABP-B-39 allowed

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Time to occurrence of first breast cancer event

Outcome Time Frame:

Every 6 months for 5 years then every 12 month thereafter

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

January 2003

Completion Date:

March 2016

Related Keywords:

  • Breast Cancer
  • breast cancer in situ
  • ductal breast carcinoma in situ
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
  • Carcinoma, Ductal



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Alta Bates Comprehensive Cancer CenterBerkeley, California  94704
Peninsula Medical CenterBurlingame, California  94010
Mount Diablo Regional Cancer CenterConcord, California  94524-4110
North Bay Cancer CenterFairfield, California  94533
Kaiser Permanente - FremontFremont, California  94538
Sutter Health - Western Division Cancer Research GroupGreenbrae, California  94904
Marin Cancer Institute at Marin General HospitalGreenbrae, California  94904
Saint Rose HospitalHayward, California  94545
Kaiser Permanente Medical Center - HaywardHayward, California  94545
Moores UCSD Cancer CenterLa Jolla, California  92093-0658
Memorial Medical Center Cancer ServicesModesto, California  95355
Highland General Hospital at St. George's University School of MedicineOakland, California  94602
Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Valley Care Medical CenterPleasanton, California  94588
Kaiser Permanente Medical Center - Redwood CityRedwood City, California  94063
Kaiser Permanente Medical Center - RichmondRichmond, California  94801
Kaiser Permanente Medical Center - RosevilleRoseville, California  95661
Sutter Cancer Center at Roseville Medical CenterRoseville, California  95661
South Sacramento Kaiser-Permanente Medical CenterSacramento, California  95823
Salinas Valley Memorial HospitalSalinas, California  93901
California Pacific Medical Center - California CampusSan Francisco, California  94118
Kaiser Permanente Medical Center - Santa TeresaSan Jose, California  95119
J.C. Robinson, M.D. Regional Cancer CenterSan Pablo, California  94806
Kaiser Foundation Hospital - San RafaelSan Rafael, California  94903
Kaiser Permanente Medical Center - Santa RosaSanta Rosa, California  95403
Kaiser Permanente Medical Center - South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente Medical Facility - StocktonStockton, California  95210
Sutter Solano Medical CenterVallejo, California  94589
Kaiser Permanente Medical Center - Walnut CreekWalnut Creek, California  94596
John Muir/Mt. Diablo Comprehensive Cancer CenterWalnut Creek, California  94598
Memorial HospitalColorado Springs, Colorado  80909
Poudre Valley HospitalFort Collins, Colorado  80524
St. Mary-Corwin Regional Medical CenterPueblo, Colorado  81004
Beebe Medical CenterLewes, Delaware  19958
St. Francis HospitalWilmington, Delaware  19805
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross HospitalFort Lauderdale, Florida  33308
Ella Milbank Foshay Cancer Center at Jupiter Medical CenterJupiter, Florida  33458
M.D. Anderson Cancer Center - OrlandoOrlando, Florida  32806
Saint Joseph's Hospital of AtlantaAtlanta, Georgia  30342-1701
Piedmont HospitalAtlanta, Georgia  30309
WellStar Cobb HospitalAustell, Georgia  30106
Charles B. Eberhart Cancer Center at DeKalb Medical CenterDecatur, Georgia  30033
Gwinnett Medical CenterLawrenceville, Georgia  30045
Kennestone Cancer Center at Wellstar Kennestone HospitalMarietta, Georgia  30060
Southern Regional Medical CenterRiverdale, Georgia  30274-2600
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical CenterBoise, Idaho  83706
St. Joseph Medical CenterBloomington, Illinois  61701
Graham HospitalCanton, Illinois  61520
Memorial HospitalCarthage, Illinois  62321
Swedish Covenant HospitalChicago, Illinois  60625
Mercy Hospital and Medical CenterChicago, Illinois  60616
Eureka Community HospitalEureka, Illinois  61530
Galesburg Cottage HospitalGalesburg, Illinois  61401
Galesburg ClinicGalesburg, Illinois  61401
InterCommunity Cancer Center of Western IllinoisGalesburg, Illinois  61401
Ingalls Cancer Care Center at Ingalls Memorial HospitalHarvey, Illinois  60426
Mason District HospitalHavana, Illinois  62644
Hopedale Medical ComplexHopedale, Illinois  61747
Kewanee HospitalKewanee, Illinois  61443
McDonough District HospitalMacomb, Illinois  61455
Trinity Medical Center - EastMoline, Illinois  61265
Edward Hospital Cancer CenterNaperville, Illinois  60540
BroMenn Regional Medical CenterNormal, Illinois  61761
Community Cancer CenterNormal, Illinois  61761
Community Hospital of OttawaOttawa, Illinois  61350
Cancer Treatment Center at Pekin HospitalPekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - PeoriaPeoria, Illinois  61615
OSF St. Francis Medical CenterPeoria, Illinois  61637
Proctor HospitalPeoria, Illinois  61614
Illinois Valley Community HospitalPeru, Illinois  61354
Perry Memorial HospitalPrinceton, Illinois  61356
Hematology/Oncology of the North Shore at Gross Point Medical CenterSkokie, Illinois  60076
St. Margaret's HospitalSpring Valley, Illinois  61362
Valley Cancer CenterSpring Valley, Illinois  61362
St. Francis Hospital and Health Centers - Beech Grove CampusBeech Grove, Indiana  46107
Howard Community Hospital at Howard Regional Health SystemKokomo, Indiana  46904
Center for Cancer Therapy at LaPorte Hospital and Health ServicesLa Porte, Indiana  46350
McFarland Clinic, P. C.Ames, Iowa  50010
St. Luke's HospitalCedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical CenterCedar Rapids, Iowa  52403
Genesis Regional Cancer Center at Genesis Medical CenterDavenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Mercy Capitol HospitalDes Moines, Iowa  50307
Medical Oncology and Hematology Associates at John Stoddard Cancer CenterDes Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer CenterDes Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates - West Des MoinesWest Des Moines, Iowa  50266
Cancer Center of Kansas, PA - Dodge CityDodge City, Kansas  67801
Stormont-Vail Cancer CenterTopeka, Kansas  66604
St. Francis Comprehensive Cancer CenterTopeka, Kansas  66606
Cancer Center of Kansas, P.A. - WellingtonWellington, Kansas  67152
Associates in Womens Health, P.A. - North ReviewWichita, Kansas  67203
Cancer Center of Kansas, P.A. - WinfieldWinfield, Kansas  67156
Ochsner Clinic of Baton RougeBaton Rouge, Louisiana  708169990
Terrebonne General Medical CenterHouma, Louisiana  70360
Feist-Weiller Cancer Center at Louisiana State University Health SciencesShreveport, Louisiana  71130-3932
Union Hospital Cancer Center at Union HospitalElkton MD, Maryland  21921
Sturdy Memorial HospitalAttleboro, Massachusetts  02703
Franklin Medical CenterGreenfield, Massachusetts  01301
Hickman Cancer Center at Bixby Medical CenterAdrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy HospitalAnn Arbor, Michigan  48106-0995
Bay Regional Medical CenterBay City, Michigan  48708
Mecosta County Medical CenterBig Rapids, Michigan  49307
Green Bay Oncology, Limited - Iron MountainIron Mountain, Michigan  49801
Upper Michigan Cancer Center at Marquette General HospitalMarquette, Michigan  49855
Mercy Memorial Hospital SystemMonroe, Michigan  48162
Providence Cancer Institute at Providence Hospital - Southfield CampusSouthfield, Michigan  48075
MeritCare Clinic - BemidjiBemidji, Minnesota  56601
Virginia Piper Cancer Institute at Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Hubert H. Humphrey Cancer Center at North Memorial Medical CenterRobbinsdale, Minnesota  55422-2900
CentraCare Clinic - River CampusSt. Cloud, Minnesota  56303
Park Nicollet Health ServicesSt. Louis Park, Minnesota  55416
Hattiesburg Clinic, P.A.Hattiesburg, Mississippi  39401
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Immanuel Medical CenterOmaha, Nebraska  68122
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Booker Cancer Center at Riverview Medical CenterRed Bank, New Jersey  07701
Fox Chase Cancer Center at St. Francis Medical CenterTrenton, New Jersey  08629
Cancer Institute of New Jersey at Cooper - VoorheesVoorhees, New Jersey  08043
Charles R. Wood Cancer Center at Glens Falls HospitalGlens Falls, New York  12801
Wilson Medical CenterWilson, North Carolina  27893-3428
Forsyth Regional Cancer Center at Forsyth Medical CenterWinston-Salem, North Carolina  27103
Cancer Care Center at Medcenter One HospitalBismarck, North Dakota  58501
Bismarck Cancer CenterBismarck, North Dakota  58501
St. Alexius Medical CenterBismarck, North Dakota  58502
Mid Dakota Clinic, P. C.Bismarck, North Dakota  58501
MeritCare Medical GroupFargo, North Dakota  58122
Samaritan North Cancer Care CenterDayton, Ohio  45415
Grandview HospitalDayton, Ohio  45405
Good Samaritan HospitalDayton, Ohio  45406
Blanchard Valley Medical AssociatesFindlay, Ohio  45840
Fremont Memorial HospitalFremont, Ohio  43420
Community Oncology Group at Cleveland Clinic Cancer CenterIndependence, Ohio  44131
Charles F. Kettering Memorial HospitalKettering, Ohio  45429
Lima Memorial HospitalLima, Ohio  45804
St. Luke's HospitalMaumee, Ohio  43537
Northwest Ohio Oncology CenterMaumee, Ohio  43537
Middletown Regional HospitalMiddletown, Ohio  45044
St. Charles Mercy HospitalOregon, Ohio  43616
Firelands Regional Medical CenterSandusky, Ohio  44870
Mercy Medical CenterSpringfield, Ohio  45504
Promedica Cancer Center at Flower HospitalSylvania, Ohio  43560
Mercy Hospital of TiffinTiffin, Ohio  44883
Toledo Clinic, Incorporated - Main ClinicToledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical CenterTroy, Ohio  45373-1300
Fulton County Health CenterWauseon, Ohio  43567
Cleveland Clinic - WoosterWooster, Ohio  44691
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXenia, Ohio  45385
Comanche County Memorial HospitalLawton, Oklahoma  73505
LaFortune Cancer Center at St. John Medical CenterTulsa, Oklahoma  74104
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer CenterPortland, Oregon  97210
Kaiser Permanente Health Care - PortlandPortland, Oregon  97232
Providence Cancer Center at Providence Portland Medical CenterPortland, Oregon  97213-2967
Providence St. Vincent Medical CenterPortland, Oregon  97225
Legacy Meridian Park HospitalTualatin, Oregon  97062
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
Delaware County Regional Cancer Center at Delaware County Memorial HospitalDrexel Hill, Pennsylvania  19026
St. Mary Regional Cancer CenterLanghorne, Pennsylvania  19047
Hematology and Oncology AssociatesScranton, Pennsylvania  18510
Lankenau Cancer Center at Lankenau HospitalWynnewood, Pennsylvania  19096
Bon Secours St. Francis Health SystemGreenville, South Carolina  29601
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical CenterKingsport, Tennessee  37662
Doctor's Hospital of LaredoLaredo, Texas  78041
Dixie Regional Medical Center - East CampusSaint George, Utah  84770
Southwestern Vermont Regional Cancer CenterBennington, Vermont  05201
Mountainview MedicalBerlin, Vermont  05602
Mount Ascutney HospitalWindsor, Vermont  05089
Danville Regional Medical CenterDanville, Virginia  24541
Virginia Oncology Associates - HamptonHampton, Virginia  23666
Southwest Washington Medical Center Cancer CenterVancouver, Washington  98668
Green Bay Oncology, Limited at St. Vincent HospitalGreen Bay, Wisconsin  54301-3526
Dean Medical Center - Fish HatcheryMadison, Wisconsin  53715
Fairbanks Cancer Treatment Center at Fairbanks Memorial HospitalFairbanks, Alaska  99701
DeCesaris Cancer Institute at Anne Arundel Medical CenterAnnapolis, Maryland  21401
St. Francis HospitalFederal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical CenterKirkland, Washington  98034-3013
St. Clare HospitalLakewood, Washington  98499-0998
Capital Medical CenterOlympia, Washington  98502
Providence St. Peter Hospital Regional Cancer CenterOlympia, Washington  98506
Good Samaritan Cancer CenterPuyallup, Washington  98371
Valley Medical CenterRenton, Washington  98055
St. Joseph Medical Center at Franciscan Health SystemTacoma, Washington  98405-3004
Allenmore HospitalTacoma, Washington  98411-0414
Miller-Dwan Medical CenterDuluth, Minnesota  55805
Rice Memorial HospitalWillmar, Minnesota  56201
Pottstown Memorial Regional Cancer CenterPottstown, Pennsylvania  19464
Franciscan Skemp HealthcareLa Crosse, Wisconsin  54601-4796
California Cancer Center - Woodward Park OfficeFresno, California  93720
Providence Holy Cross Cancer CenterMission Hills, California  91346-9600
Middlesex Hospital Cancer CenterMiddletown, Connecticut  06457
Northeast Georgia Medical CenterGainesville, Georgia  30501
Creticos Cancer Center at Advocate Illinois Masonic Medical CenterChicago, Illinois  60657
Wendt Regional Cancer Center at Finley HospitalDubuque, Iowa  52001
Mercy Cancer Center at Mercy Medical Center - North IowaMason City, Iowa  50401
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins CountyMadisonville, Kentucky  42431
Central Maine Medical CenterLewiston, Maine  04240
Hudner Oncology Center at Saint Anne's HospitalFall River, Massachusetts  02721
Great Lakes Cancer Institute at McLaren Regional Medical CenterFlint, Michigan  48532
Cancer Care Center at St. Luke's HospitalDuluth, Minnesota  55805
Saint Francis Cancer CenterShakopee, Minnesota  55379
St. Joseph's HospitalSt Paul, Minnesota  55102
Regional Cancer Center at Singing River HospitalPascagoula, Mississippi  39581
Missouri Baptist Cancer CenterSt. Louis, Missouri  63131
Cancer Resource Center - LincolnLincoln, Nebraska  68510
Washoe Cancer Services at Washoe Medical Center - RenoReno, Nevada  89502
South Jersey Healthcare Regional Cancer CenterMillville, New Jersey  08332
Capital Health System Regional Cancer CenterTrenton, New Jersey  08618
Moses Cone Regional Cancer Center at Wesley Long Community HospitalGreensboro, North Carolina  27401
Altru Cancer Center at Altru HospitalGrand Forks, North Dakota  58201
Huron Hospital Cancer Care CenterCleveland, Ohio  44112
Euclid HospitalCleveland, Ohio  44119
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - OxfordSalem, Ohio  44460
South Pointe Hospital Cancer Care CenterWarrensville Heights, Ohio  44122
Cancer Treatment CenterWooster, Ohio  44691
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania HospitalPittsburgh, Pennsylvania  15224-1791
St. Joseph Medical CenterReading, Pennsylvania  19604
Praxair Cancer Center at Danbury HospitalDanbury, Connecticut  06810
Carl and Dorothy Bennett Cancer Center at Stamford HospitalStamford, Connecticut  06904
Florida Cancer Specialists - Sarasota DowntownSarasota, Florida  34236
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/CandlerSavannah, Georgia  31405
Covenant Cancer Treatment CenterWaterloo, Iowa  50702
Christ Hospital Cancer CenterCincinnati, Ohio  45219
Salem Hospital Regional Cancer Care ServicesSalem, Oregon  97309-5014
Schiffler Cancer Center at Wheeling HospitalWheeling, West Virginia  26003
Oncology Alliance, SC - Milwaukee - EastGlendale, Wisconsin  53212-1038
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311
Ministry Medical Group at Saint Mary's HospitalRhinelander, Wisconsin  54501
Cancer Resource Center at King's Daughters Medical CenterAshland, Kentucky  41101
Methodist Cancer Center at Methodist Hospital - OmahaOmaha, Nebraska  68114
Regional Cancer Center at Memorial Medical CenterSpringfield, Illinois  62781-0001
Saint Louis University Cancer CenterSaint Louis, Missouri  63110
Auburn Regional Center for Cancer CareAuburn, Washington  98002
Morton Plant HospitalClearwater, Florida  33756
Community HospitalMunster, Indiana  46321
Alamance Cancer CenterBurlington, North Carolina  27216
Memorial Hospital of Rhode IslandPawtucket, Rhode Island  02860
Sacred Heart HospitalAllentown, Pennsylvania  18102
Phoebe Cancer Center at Phoebe Putney Memorial HospitalAlbany, Georgia  31702
Seton Shivers Cancer Program at Brackenridge HospitalAustin, Texas  78701
Saint Joseph's Mercy Cancer CenterHot Springs, Arkansas  71913
Washington Township HospitalFremont, California  94538
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical CenterPomona, California  91767
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity HospitalWhittier, California  90602
Hematology Oncology Associates of Eastern IdahoIdaho Falls, Idaho  83404
Regional Cancer Institute at Bloomington HospitalBloomington, Indiana  47403
Greater Baltimore Medical CenterBaltimore, Maryland  21204
MetroWest Medical Center - Framingham Union HospitalFramingham, Massachusetts  01702
Caritas Norwood HospitalNorwood, Massachusetts  02062
Seacoast Cancer Center at Wentworth-Douglass HospitalDover, New Hampshire  03820
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical CenterEnglewood, New Jersey  07631
AtlantiCare Regional Medical CenterPomona, New Jersey  08240
Tucker Center for Cancer Care at Orange Regional Medical CenterMiddletown, New York  10940-4199
Pardee Memorial HospitalHendersonville, North Carolina  28791
Moore Regional Community Hospital Comprehensive Cancer CenterPinehurst, North Carolina  28374
Bethesda North HospitalCincinnati, Ohio  45242
Cancer Treatment Center at Good Samaritan HospitalCincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health CenterWarren, Ohio  44484
Easton Regional Cancer Center at Easton HospitalEaston, Pennsylvania  18042
Mercy Cancer Institute at Mercy HospitalPittsburgh, Pennsylvania  15219
York Cancer Center at Wellspan HealthYork, Pennsylvania  17403
Community Cancer Center at Rutland Regional Medical CenterRutland, Vermont  05701
Martha Jefferson Hospital Cancer Care CenterCharlottesville, Virginia  22901
Theda Care Cancer InstituteAppleton, Wisconsin  54911
Community Memorial Hospital Cancer Care CenterMenomonee Falls, Wisconsin  53051
Regional Cancer Center - ErieErie, Pennsylvania  16505
MedCentral - Mansfield HospitalMansfield, Ohio  44903
Glendale Memorial Hospital Comprehensive Cancer CenterGlendale, California  91204
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long BeachLong Beach, California  90813
St. Vincent's Medical CenterJacksonville, Florida  32203
Resurrection Medical CenterChicago, Illinois  60631
Sherman HospitalElgin, Illinois  60120-2198
Center for Cancer Care at Goshen Health SystemGoshen, Indiana  46526
Cancer Treatment Center at Christus Schumpert St. Mary PlaceShreveport, Louisiana  71101
Frederick Memorial Hospital Regional Cancer Therapy CenterFrederick, Maryland  21701
Jordan Hospital Club Cancer CenterPlymouth, Massachusetts  02360
St. John's Regional Medical CenterJoplin, Missouri  64804
Freeman Cancer Institute at Freeman Health SystemJoplin, Missouri  64803-2644
Underwood Memorial HospitalWoodbury, New Jersey  08096
New Mexico Cancer Care AssociatesSanta Fe, New Mexico  87505-7670
Mercy Health CenterOklahoma City, Oklahoma  73120
McLeod Regional Medical CenterFlorence, South Carolina  29501
U.T. Cancer Institute at University of Tennessee Medical CenterKnoxville, Tennessee  37920-2911
Presbyterian Hospital of DallasDallas, Texas  75231
St. Joseph Mercy HospitalPontiac, Michigan  48341-2985
Huntsville HospitalHuntsville, Alabama  35807
Nalitt Cancer Institute at Staten Island University HospitalStaten Island, New York  10305
Sentara Cancer Institute at Sentara Norfolk General HospitalNorfolk, Virginia  23507
Arch Medical Services, Incorporated at Center for Cancer Care ResearchSaint Louis, Missouri  63141
Lakes Region General HospitalLaconia, New Hampshire  03246
St. Charles Medical Center - BendBend, Oregon  97701
PinnacleHealth Regional Cancer Center at Polyclinic HospitalHarrisburg, Pennsylvania  17105
Cancer Care Institute of Carolina at Aiken Regional Medical CentersAiken, South Carolina  29801
Roper St. Francis Cancer Center at Roper HospitalCharleston, South Carolina  29401
Lynn Regional Cancer Center at Boca Raton Community Hospital - Main CenterBoca Raton, Florida  33486
Lipson Cancer and Blood Center at Rochester General HospitalRochester, New York  14621
Newton-Wellesley HospitalNewton, Massachusetts  02462
Woodwinds Health CampusWoodbury, Minnesota  55125
Cancer Center at Phoenixville HospitalPhoenixville, Pennsylvania  19460
Marshall University Medical CenterHuntington, West Virginia  25701
Center for Cancer Care at OSF Saint Anthony Medical CenterRockford, Illinois  61108
Louisville Oncology at Norton Cancer CenterLouisville, Kentucky  40202
Rappahannock General HospitalKilmarnock, Virginia  22482
Desert Regional Medical Center Comprehensive Cancer CenterPalm Springs, California  92262
Oncology Care Associates, PLLCSaint Joseph, Michigan  49085
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Mercy General HospitalSacramento, California  95819
Alexian Brothers Radiation OncologyElk Grove Village, Illinois  60007
Elmhurst Memorial HospitalElmhurst, Illinois  60126
Iowa Blood and Cancer CareCedar Rapids, Iowa  52402
Caritas St. Elizabeth's Medical CenterBrighton, Massachusetts  02135-2997
Valley Hospital - RidgewoodRidgewood, New Jersey  07450
Bay Area HospitalCoos Bay, Oregon  97420
St. Joseph's Hospital Health Center - SyracuseSyracuse, New York  13203
Dale and Frances Hughes Cancer Center at Pocono Medical CenterEast Stroudsburg, Pennsylvania  18301
Associates in Hematology-Oncology, PC at Crozer Regional Cancer CenterUpland, Pennsylvania  19013
Watson Clinic, LLCLakeland, Florida  33804-5000
John B. Amos Community Cancer CenterColumbus, Georgia  31902
Provena St. Mary's Wasser Regional Cancer Center - KankakeeKankakee, Illinois  60901
Lawrence Memorial Hospital of MedfordMedford, Massachusetts  02155
St. Anthony's Cancer CenterSt. Louis, Missouri  63128
University of Wisconsin Cancer Center at Aspirus Wausau HospitalWausau, Wisconsin  54401
Medical and Surgical Specialists, L L CGalesburg, Illinois  61401
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia FieldsOlympia Fields, Illinois  60461
Commonwealth Hematology-Oncology P. C. - QuincyQuincy, Massachusetts  02169
Ted B. Wahby Cancer Center at Mount Clemens General HospitalMount Clemens, Michigan  48043
Lovelace Medical CenterAlbuquerque, New Mexico  87108
United States Air Force Medical Center Wright-PattersonWright-Patterson Afb, Ohio  45433-5529
Providence Centralia Hospital Regional Cancer CenterCentralia, Washington  98531
New York Oncology Hematology, P.C.Albany, New York  12208
St. Mary's Regional Cancer Center at St. Mary's Medical CenterHuntington, West Virginia  25702
Ocean Medical Center at Meridian HealthBrick, New Jersey  08724
High Point Regional HospitalHigh Point, North Carolina  27261
Augusta Oncology Associates - Walton WayAugusta, Georgia  30901
MaineGeneral Medical Center - Waterville CampusWaterville, Maine  04901
South Shore HospitalSouth Weymouth, Massachusetts  02190
Albert Lea Cancer Center at Albert Lea Medical CenterAlbert Lea, Minnesota  56007
Carson-Tahoe Cancer Services at Carson Tahoe Regional HealthcareCarson City, Nevada  89703
Parkland Oncology-Hematology Clinic at Parkland Medical CenterDerry, New Hampshire  03038
Meadville Medical CenterMeadville, Pennsylvania  16335
Ottumwa Regional Health Center Cancer CenterOttumwa, Iowa  52501
Erlanger Cancer CenterChattanooga, Tennessee  37403
Northeast Georgia Cancer Care, LLCAthens, Georgia  30607
All Saints Cancer Center at All Saints Medical CenterRacine, Wisconsin  53405
Hematology Oncology Associates, PCAlbuquerque, New Mexico  87106
NSMC Cancer Center - PeabodyPeabody, Massachusetts  01960
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical CenterPlattsburgh, New York  12901
Mercy Regional Cancer CenterJanesville, Wisconsin  53547
Integris Oncology ServicesOklahoma City, Oklahoma  73112
Fox Valley Surgical Associates at Appleton Medical CenterAppleton, Wisconsin  54911-3454
East Alabama Medical CenterOpelika, Alabama  36801-5452
Cancer Center at Providence Alaska Medical CenterAnchorage, Alaska  99519-6604
Shore Regional Cancer Center at Memorial Hospital - EastonEaston, Maryland  21601
Mercy Medical CenterBaltimore, Maryland  21202
Virginia K. Crosson Cancer Center at St. Jude Medical CenterFullerton, California  92835
Stevens Cancer Center at Scripps Memorial HospitalLa Jolla, California  92037-1276
Robert and Carol Weissman Cancer Center at Martin MemorialStuart, Florida  34994
Emory Crawford Long HospitalAtlanta, Georgia  30308
Portneuf Cancer Center at Portneuf Medical CenterPocatello, Idaho  83201
Delnor Community Hospital - GenevaGeneva, Illinois  60134
Methodist Cancer Center at Clarian HealthIndianapolis, Indiana  46202
Arnett Cancer CareLafayette, Indiana  47904
Cedar Valley Medical Specialists, P.C. - West Ridgeway AvenueWaterloo, Iowa  50702
Mount Carmel Regional Cancer CenterPittsburg, Kansas  66762
St. Mary's HospitalLeonardtown, Maryland  20650
Kaiser Permanente Capital Area Medical Group - Shady Grove FacilityRockville, Maryland  20850
Holy Cross HospitalSilver Spring, Maryland  20910
Cancer Institute at St. Joseph Medical CenterTowson, Maryland  21204
Caritas Holy Family HospitalMethuen, Massachusetts  01844
Exeter Hospital Center for Cancer CareExeter, New Hampshire  03833
Santa Fe Cancer Center at St. Vincent HospitalSanta Fe, New Mexico  87505
New York Oncology Hematology, PC at Albany Regional Cancer CareAlbany, New York  12208
Amsterdam Community Cancer ProgramAmsterdam, New York  12010
Falck Cancer Center at Arnot Ogden Medical CenterElmira, New York  14905
New York Oncology Hematology, P.C. at Cavell Cancer Treatment ProgramHudson, New York  12534
Union State Bank Cancer Center at Nyack HospitalNyack, New York  10960-1998
Riverview Cancer Care Medical Associates, PCRexford, New York  12148
Genesee Surgical Associates - Linden Oaks Medical CampusRochester, New York  14625
New York Oncology Hematology, P.C. - Ellis OfficeSchenectady, New York  12308
Samaritan Hospital at Northeast HealthTroy, New York  12180
Oncology Hematology Care, Incorporated - Blue AshCincinnati, Ohio  45242
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer CenterDubois, Pennsylvania  15801
Ephrata Cancer Center at Ephrata Community HospitalEphrata, Pennsylvania  17522
Richard G. Laube Cancer Center at Armstrong County Memorial HospitalKittanning, Pennsylvania  16201
Cancer Center at Riddle Memorial HospitalMedia, Pennsylvania  19063
Chestnut Hill Healthcare Cancer CenterPhiladelphia, Pennsylvania  19118
Frankford Hospital - Torresdale CampusPhiladelphia, Pennsylvania  19114
Baylor University Medical Center - DallasDallas, Texas  75246
Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry CountyMartinsville, Virginia  24115
Peninsula Cancer InstituteNewport News, Virginia  23601
Overlake Cancer Center at Overtake Hospital Medical CenterBellevue, Washington  98004
St. Mary Regional Cancer Center at St. Mary Medical CenterWalla Walla, Washington  99362
Central Wisconsin Cancer Program at Agnesian HealthCareFond du Lac, Wisconsin  54935
St. Joseph Regional Medical CenterMilwaukee, Wisconsin  53210