Trial Information

A Pilot Study To Correlate DNA Sequence Copy Number Abnormalities With Outcome In Patients With Advanced Epithelial Ovarian Cancer

OBJECTIVES:

- Utilize array comparative genomic hybridization and Taqman analyses, a quantitative
genomic polymerase chain reaction, to validate the observation that a gain in
chromosome 8q is predictive of shorter progression-free survival in patients with
primary grade 2 or grade 3 advanced serous papillary ovarian cancer.

- Utilize these analyses to determine whether a gain in chromosome 8q is predictive of
worse overall survival in these patients.

- Utilize these analyses to determine whether other previously identified chromosomal
changes (3q gain, 7q gain, 16q loss, and 17pter-q21 loss) predict outcome in these
patients and the association between these changes and clinical characteristics.

- Utilize these analyses to identify up to 5 additional chromosomal changes and their
association that may predict outcome (progression-free and overall survival) in these
patients.

OUTLINE: Genomic DNA is isolated from OCT-embedded tissue and analyzed using comparative
genomic hybridization. The chromosomal changes identified by this method are compared to
those identified using the Taqman method, a quantitative genomic polymerase chain reaction
analysis. Chromosome 8q is of specific interest. Other chromosomal changes may be detected
in chromosomes 3q, 7q, 16q, and/or 17pter-q21.

PROJECTED ACCRUAL: A total of 158 patient samples will be collected for this study.