Health-Related Quality Of Life In Patients With Low Risk, Localized Prostate Cancer Randomized To Radical Prostatectomy Or Brachytherapy
- Compare changes in health-related quality of life (HRQOL) in patients with stage II
prostate cancer up to 2 years after treatment with radical prostatectomy or
- Compare the effect of baseline HRQOL, age, and other covariates on HRQOL improvement or
deterioration in these patients up to 10 years after these treatments.
- Compare the effect of treatment modality on HRQOL improvement or deterioration in these
patients up to 10 years after these treatments.
- Compare the effects of treatment failure on HRQOL, in terms of disease progression, in
OUTLINE: Patients are randomized to 1 of 2 arms on ACOSOG-Z0070 (radical prostatectomy vs
Patients in both arms complete a quality of life questionnaire at baseline, 2 and 6 months
after treatment, and then at 1, 2, 4, 7, and 10 years after treatment.
PROJECTED ACCRUAL: A total of 500 patients (250 per group) will be accrued for this study
within 2 years.
Martin G. Sanda, MD
Beth Israel Deaconess Medical Center
United States: Federal Government
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|
|Walter Reed Army Medical Center||Washington, District of Columbia 20307-5000|
|Washington University School of Medicine||Saint Louis, Missouri 63110|
|Beth Israel Deaconess Medical Center||Boston, Massachusetts 02215|
|Holden Comprehensive Cancer Center at University of Iowa||Iowa City, Iowa 52242-1002|
|Cleveland Clinic Taussig Cancer Center||Cleveland, Ohio 44195|
|Madigan Army Medical Center||Tacoma, Washington 98431-5048|
|UCSF Comprehensive Cancer Center||San Francisco, California 94115|
|James P. Wilmot Cancer Center at University of Rochester Medical Center||Rochester, New York 14642|
|University Cancer Center at University of Washington Medical Center||Seattle, Washington 98195|
|Fletcher Allen Health Care - Medical Center Campus||Burlington, Vermont 05401|
|Sentara Norfolk General Hospital||Norfolk, Virginia 23507|
|Presbyterian Hospital||Charlotte, North Carolina 28233-3549|