Inclusion Criteria:

- Diagnosis of primary malignant brain tumor and receiving treatment in the UCLA
Neuro-Oncology Program

- Nonmalignant cerebral tumors also allowed

- Received some combination of prior therapy for disease, including neurosurgical
resection, radiotherapy, and cytotoxic or cytostatic chemotherapy

- Mild to severe fatigue and/or attention/memory impairment, as measured by the
Clinical Global Impression of Severity Scale

- Age 21 to 65

- Able to speak English

- Capable of completing self-rating scales and one-on-one psychometric tests

- Negative pregnancy test

- Fertile patients must use effective contraception

- Concurrent conventional chemotherapy (e.g., carboplatin, lomustine, temozolomide)
allowed

- Concurrent glucocorticoids (e.g., dexamethasone) allowed

- Concurrent tamoxifen allowed

- At least 30 days since prior stimulants (e.g., amphetamines or methylphenidate)

- Concurrent anticonvulsants allowed

- Concurrent isotretinoin allowed

Exclusion Criteria:

- Have significant hepatic disease, defined as SGOT greater than or equal to 2.5 times
the upper limit of normal.

- Have significant renal disease, defined as creatinine greater than or equal to
1.5mg/dl.

- severe cognitive impairment

- other terminal illness

- emergency patient

- institutional resident

- prisoner or parolee

- UCLA students or staff

- pregnant or nursing

- concurrent irinotecan

- concurrent participation in UCLA experimental chemotherapy trials

- prior modafinil

- concurrent experimental anticancer medication

- concurrent tricyclic antidepressants and/or monoamine oxidase inhibitors