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Phase 2/Phase 3
18 Years
Not Enrolling
Lymphoma, Non-Hodgkin

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Trial Information

Inclusion Criteria

Diagnosis and disease status:

- Subjects with CD20+, B-cell, Non-Hodgkin's lymphoma of low-grade or follicular
histology with measurable relapsed or unresponsive disease after prior therapy;
mantle cell and chronic lymphocytic leukemia subtypes are excluded.

- Subjects who previously received a single-agent course of rituximab and showed no
tumor response, or had a response lasting < 6 months. The previously administered
rituximab must have included at least 75% of the standard 4-week regimen (4 x 375
mg/m2). A record of the previous rituximab treatment and response must be available
as a source document at the site.


- Subjects who showed no tumor response or a response lasting <6 months to treatment
with Rituximab in combination with Chemotherapy or another therapeutic modality
(radiation or radioimmunoconjugates).

- HIV positive.

- Symptomatic thyroid disease requiring medical intervention other than replacement
treatment for hypothyroidism.

- Clinically significant cardiac, pulmonary, and /or hepatic dysfunction (if subject
has history of congestive heart failure or myocardial infarction, must have been
stable for at least 6 months, and have no current symptoms

- If cardiac ejection fraction has been measured, it must be greater than 50%.

Type of Study:


Study Design:

Primary Purpose: Treatment


United States: Food and Drug Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Lymphoma, Non-Hodgkin
  • Low-Grade or Follicular Non-Hodgkin's Lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin



University of Iowa Hospitals and Clinics Iowa City, Iowa  52242
Mount Sinai School of Medicine New York, New York  10029
Fletcher Allen Health Care Burlington, Vermont  05401
Whittingham Cancer Center Norwalk, Connecticut  06856
John Wayne Cancer Institute Santa Monica, California  90404
Cancer Research Center of Hawaii Honolulu, Hawaii  96813
University of Arkansas for Medical Sciences Little Rock, Arkansas  72205
Comprehensive Cancer Centers of Nevada Las Vegas, Nevada  89109
Cancer Centers of the Carolinas Greenville, South Carolina  29605
Benefis Healthcare Great Falls, Montana  59403
Comprehensive Blood and Cancer Center Bakersfield, California  93309
Cancer Care Center New Albany, Indiana  47150
Pacific Shores Medical Group Long Beach, California  90813
Consultants in Blood Disorders and Cancer Louisville, Kentucky  40207
Southwest Cancer Care Poway, California  92064
Oregon Health & Science University Portland, Oregon  97201
Advanced Oncology Associates Armonk, New York  10504
Northwestern University Medical School Chicago, Illinois  60611-2927
The Cleveland Clinic Foundation Cleveland, Ohio  
Kansas City Oncology and Hematology Group Kansas City, Missouri  64111
Hoag Cancer Center Newport Beach, California  92658
Hematology Oncology Consultants, Inc. Columbus, Ohio  43235
UC Davis Cancer Center Sacramento, California  95817
Gabrail Cancer Center Canton, Ohio  44718
Virginia Cancer Institute Richmond, Virginia  23230
California Oncology of the Central Valley Fresno, California  93710
Virginia K. Crosson Cancer Center Fullerton, California  92835
Wilshire Oncology Medical Group Glendora, California  91741
California Cancer Care Inc. Greenbrae, California  94904
Santa Barbara Hematology Oncology Medical Group Lompoc, California  93438
UCLS Medical Center Los Angeles, California  90095
Facey Medical Foundation Mission Hills, California  91345
North Valley Hematology-Oncology Medical Group Mission Hills, California  91345
North Valley Hematology/Oncology Medical Group Northridge, California  91328
Ventura County Hematology-Oncology Specialists Oxnard, California  93030
UCLA Medical Group/Pasadena Oncology Pasadena, California  91105
Cancer Care Associates Meidcal Group, Inc. Redondo Beach, California  90277
Sansum Santa Barbara Foundation Medical Clinic Santa Barbara, California  93105
Santa Barbara Hematology Oncology Medical Group, Inc. Santa Barbara, California  93105
Cancer Care Associates Medical Group, Inc. Torrance, California  90505
UCLA/Santa Clarita Valley Cancer Center Valencia, California  91355
San Diego Cancer Center Medical Group Vista, California  92083
Division of Hematology/Oncology, University of Miami, School of Medicine Miami, Florida  33136
Oncology Specialists,S.C. Park Ridge, Illinois  60068
Indiana Oncology and Hematology Consultants Indianapolis, Indiana  46202
Hematology and Oncology Specialists, LLC New Orleans, Louisiana  70115
Louisiana State University Health Sciences Center and VA Shreveport, Louisiana  71130
Maine Center for Cancer Medicine & Blood Disorders Scarborough, Maine  04074
Northern New Jersey Cancer Associates Hackensack, New Jersey  07601
Erie County Medical Center Buffalo, New York  14215
Weill Medical College of Cornell University/New York Presbyterian Hospital New York, New York  10021
East Carolina University School of Medicine, Department of Medicine, Division of Hematology/Oncology Greenville, North Carolina  27858-4354
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio  43210
Germantown Cancer Foundation Germantown, Tennessee  38138