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Phase 2/Phase 3
18 Years
N/A
Not Enrolling
Both
Lymphoma, Non-Hodgkin

Thank you

Trial Information

Inclusion Criteria


Diagnosis and disease status:

- Subjects with CD20+, B-cell, Non-Hodgkin's lymphoma of low-grade or follicular
histology with measurable relapsed or unresponsive disease after prior therapy;
mantle cell and chronic lymphocytic leukemia subtypes are excluded.

- Subjects who previously received a single-agent course of rituximab and showed no
tumor response, or had a response lasting < 6 months. The previously administered
rituximab must have included at least 75% of the standard 4-week regimen (4 x 375
mg/m2). A record of the previous rituximab treatment and response must be available
as a source document at the site.

Exclusion:

- Subjects who showed no tumor response or a response lasting <6 months to treatment
with Rituximab in combination with Chemotherapy or another therapeutic modality
(radiation or radioimmunoconjugates).

- HIV positive.

- Symptomatic thyroid disease requiring medical intervention other than replacement
treatment for hypothyroidism.

- Clinically significant cardiac, pulmonary, and /or hepatic dysfunction (if subject
has history of congestive heart failure or myocardial infarction, must have been
stable for at least 6 months, and have no current symptoms

- If cardiac ejection fraction has been measured, it must be greater than 50%.

Type of Study:

Interventional

Study Design:

Primary Purpose: Treatment

Authority:

United States: Food and Drug Administration

Study ID:

IL2NHL03

NCT ID:

NCT00045877

Start Date:

Completion Date:

Related Keywords:

  • Lymphoma, Non-Hodgkin
  • Low-Grade or Follicular Non-Hodgkin's Lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin

Name

Location

University of Iowa Hospitals and ClinicsIowa City, Iowa  52242
Mount Sinai School of MedicineNew York, New York  10029
Fletcher Allen Health CareBurlington, Vermont  05401
Whittingham Cancer CenterNorwalk, Connecticut  06856
John Wayne Cancer InstituteSanta Monica, California  90404
Cancer Research Center of HawaiiHonolulu, Hawaii  96813
University of Arkansas for Medical SciencesLittle Rock, Arkansas  72205
Comprehensive Cancer Centers of NevadaLas Vegas, Nevada  89109
Cancer Centers of the CarolinasGreenville, South Carolina  29605
Benefis HealthcareGreat Falls, Montana  59403
Comprehensive Blood and Cancer CenterBakersfield, California  93309
Cancer Care CenterNew Albany, Indiana  47150
Pacific Shores Medical GroupLong Beach, California  90813
Consultants in Blood Disorders and CancerLouisville, Kentucky  40207
Southwest Cancer CarePoway, California  92064
Oregon Health & Science UniversityPortland, Oregon  97201
Advanced Oncology AssociatesArmonk, New York  10504
Northwestern University Medical SchoolChicago, Illinois  60611-2927
The Cleveland Clinic FoundationCleveland, Ohio  
Kansas City Oncology and Hematology GroupKansas City, Missouri  64111
Hoag Cancer CenterNewport Beach, California  92658
Hematology Oncology Consultants, Inc.Columbus, Ohio  43235
UC Davis Cancer CenterSacramento, California  95817
Gabrail Cancer CenterCanton, Ohio  44718
Virginia Cancer InstituteRichmond, Virginia  23230
California Oncology of the Central ValleyFresno, California  93710
Virginia K. Crosson Cancer CenterFullerton, California  92835
Wilshire Oncology Medical GroupGlendora, California  91741
California Cancer Care Inc.Greenbrae, California  94904
Santa Barbara Hematology Oncology Medical GroupLompoc, California  93438
UCLS Medical CenterLos Angeles, California  90095
Facey Medical FoundationMission Hills, California  91345
North Valley Hematology-Oncology Medical GroupMission Hills, California  91345
North Valley Hematology/Oncology Medical GroupNorthridge, California  91328
Ventura County Hematology-Oncology SpecialistsOxnard, California  93030
UCLA Medical Group/Pasadena OncologyPasadena, California  91105
Cancer Care Associates Meidcal Group, Inc.Redondo Beach, California  90277
Sansum Santa Barbara Foundation Medical ClinicSanta Barbara, California  93105
Santa Barbara Hematology Oncology Medical Group, Inc.Santa Barbara, California  93105
Cancer Care Associates Medical Group, Inc.Torrance, California  90505
UCLA/Santa Clarita Valley Cancer CenterValencia, California  91355
San Diego Cancer Center Medical GroupVista, California  92083
Division of Hematology/Oncology, University of Miami, School of MedicineMiami, Florida  33136
Oncology Specialists,S.C.Park Ridge, Illinois  60068
Indiana Oncology and Hematology ConsultantsIndianapolis, Indiana  46202
Hematology and Oncology Specialists, LLCNew Orleans, Louisiana  70115
Louisiana State University Health Sciences Center and VAShreveport, Louisiana  71130
Maine Center for Cancer Medicine & Blood DisordersScarborough, Maine  04074
Northern New Jersey Cancer AssociatesHackensack, New Jersey  07601
Erie County Medical CenterBuffalo, New York  14215
Weill Medical College of Cornell University/New York Presbyterian HospitalNew York, New York  10021
East Carolina University School of Medicine, Department of Medicine, Division of Hematology/OncologyGreenville, North Carolina  27858-4354
Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteColumbus, Ohio  43210
Germantown Cancer FoundationGermantown, Tennessee  38138