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Phase 2
18 Years
Not Enrolling
Lymphoma, Non-Hodgkin

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Trial Information

Inclusion Criteria


- Diagnosis: CD20+ B-cell non-Hodgkin's lymphoma (NHL) classified as intermediate- or
high-grade according to the Working Formulation, subtypes D to H. Must have
measureable progressive or refractory disease after no more than three prior
chemotherapy regimens.


- Clinically significant cardiac dysfunction, or a history of myocardial infarction or
heart failure within 6 months of first study treatment

- Clinically significant pulmonary dysfunction.

- Liver disease (note hepatitis C seropositive subjects may be enrolled if they have no
active disease as demonstrated by undetectable HCV viral loads, biopsy showing no
active disease, and/or history of normal transaminases on at least three different
dates within one year of first study treatment).

- Symptomatic thyroid disease requiring medical intervention other than replacement
treatment for hypothyroidism.

- History of autoimmune disease.

- History of positive serology for human immunodeficiency virus (HIV).

Type of Study:


Study Design:

Primary Purpose: Treatment


United States: Food and Drug Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Lymphoma, Non-Hodgkin
  • Intermediate and High-Grade Non-Hodgkin's Lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin



Memorial Sloan Kettering Cancer Center New York, New York  10021
Stanford University Medical Center Stanford, California  94305-5408
John Wayne Cancer Institute Santa Monica, California  90404
Cancer Centers of the Carolinas Greenville, South Carolina  29605
Rush Cancer Institute Chicago, Illinois  60612
Vanderbilt University Medical Center Nashville, Tennessee  37232-2516
Washington Cancer Institute Washington, District of Columbia  20010
Cancer Care Center New Albany, Indiana  47150
Consultants in Blood Disorders and Cancer Louisville, Kentucky  40207
University of Pennsylvania Philadelphia, Pennsylvania  19104
California Cancer Medical Center West Covina, California  91790
The Cleveland Clinic Foundation Cleveland, Ohio  
Kansas City Oncology and Hematology Group Kansas City, Missouri  64111
Hoag Cancer Center Newport Beach, California  92658
Oncology Specialists, S.C. Park Ridge, Illinois  60068
ACRC/Arizona Clinical Research Center, Inc. Tucson, Arizona  85712
UC Davis Cancer Center Sacramento, California  95817
Georgetown University Medical Center, Lombardi Cancer Center Washington, District of Columbia  20007
Division of Hematology/Oncology, University of Miami School of Medicine Miami, Florida  333136
Northwestern University, Feinberg School of Medicine Chicago, Illinois  60611
Louisiana Health Sciences Center, Department of Medicine, Hematology/Oncology Shreveport, Louisiana  71130
Arch Medical Group, LLC St. Louis, Missouri  63141
Dartmouth-Hitchcock-Medical Center Lebanon, New Hampshire  03756
Our Lady of Mercy Medical Center, Comprehensive Cancer Center Bronx, New York  10466
East Carolina University School of Medicine/ Division of Hematology/Oncology Greenville, North Carolina  27858
Roger Maris Health System Fargo, North Dakota  58122
Gabrail Cancer Center Canton, Ohio  44718
Oncology Hematology Care Inc. Cincinnati, Ohio  45242
Hematology /Oncology Consultants Inc. Columbus, Ohio  43235
Oregon Heath and Science University Portland, Oregon  97201
Germantown Cancer Center Germantown, Tennessee  38138
Cancer Specialists of South Texas, P.A. Corpus Christi, Texas  78412
Virginia Cancer Institute Richmond, Virginia  23230