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Phase 2
18 Years
Not Enrolling
Lymphoma, Non-Hodgkin

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Trial Information

Inclusion Criteria


- Diagnosis: CD20+ B-cell non-Hodgkin's lymphoma (NHL) classified as intermediate- or
high-grade according to the Working Formulation, subtypes D to H. Must have
measureable progressive or refractory disease after no more than three prior
chemotherapy regimens.


- Clinically significant cardiac dysfunction, or a history of myocardial infarction or
heart failure within 6 months of first study treatment

- Clinically significant pulmonary dysfunction.

- Liver disease (note hepatitis C seropositive subjects may be enrolled if they have no
active disease as demonstrated by undetectable HCV viral loads, biopsy showing no
active disease, and/or history of normal transaminases on at least three different
dates within one year of first study treatment).

- Symptomatic thyroid disease requiring medical intervention other than replacement
treatment for hypothyroidism.

- History of autoimmune disease.

- History of positive serology for human immunodeficiency virus (HIV).

Type of Study:


Study Design:

Primary Purpose: Treatment


United States: Food and Drug Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Lymphoma, Non-Hodgkin
  • Intermediate and High-Grade Non-Hodgkin's Lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin



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University of PennsylvaniaPhiladelphia, Pennsylvania  19104
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Arch Medical Group, LLCSt. Louis, Missouri  63141
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East Carolina University School of Medicine/ Division of Hematology/OncologyGreenville, North Carolina  27858
Roger Maris Health SystemFargo, North Dakota  58122
Gabrail Cancer CenterCanton, Ohio  44718
Oncology Hematology Care Inc.Cincinnati, Ohio  45242
Hematology /Oncology Consultants Inc.Columbus, Ohio  43235
Oregon Heath and Science UniversityPortland, Oregon  97201
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