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A Multicenter, Randomized Trial for Stage IIIB or IV NSCLC Comparing Weekly Taxol(Paclitaxel) and Carboplatin(Paraplatin) Regimen Versus Standard Taxol and Carboplatin Administered Every Three Weeks, Followed by Weekly Taxol.

Phase 3
18 Years
Not Enrolling
Carcinoma, Non-Small-Cell Lung

Thank you

Trial Information

A Multicenter, Randomized Trial for Stage IIIB or IV NSCLC Comparing Weekly Taxol(Paclitaxel) and Carboplatin(Paraplatin) Regimen Versus Standard Taxol and Carboplatin Administered Every Three Weeks, Followed by Weekly Taxol.

Inclusion Criteria

Inclusion criteria:

- Confirmation of non-small cell bronchogenic carcinoma (epidermoid, squamous, adeno,
large cell anaplastic carcinoma, but no small cell or carcinoid) must be
histologically or cytologically confirmed.

- No prior antineoplastic chemotherapy, hormonal therapy or therapy with biological
response modifiers

- No previous irradiation to the only area of measurable disease.

Exclusion Criteria:

- Past or current history of neoplasm other than the entry diagnosis. Exceptions are
curatively treated basal cell or squamous cell skin cancer, carcinoma in situ of the
cervix or other cancers treated by surgery or radiation with a disease free survival
longer than 5 years.

- Patients who have undergone surgery less than 3 weeks prior to enrollment.

- History of serious cardiac disease not adequately controlled.

- Patients with serious active infections or other serious underlying medical

- Uncontrolled diabetes mellitis.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment


United States: Food and Drug Administration

Study ID:




Start Date:

June 2000

Completion Date:

December 2004

Related Keywords:

  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma
  • Carcinoma, Non-Small-Cell Lung



Beth Israel Deaconess Medical Center Boston, Massachusetts  02215
Community Medical Center Toms River, New Jersey  08755
Madigan Army Medical Center Tacoma, Washington  98431-5048
West Suburban Center for Cancer Care River Forest, Illinois  60305
Maimonides Medical Center Brooklyn, New York  11219
Creighton University Cancer Center Omaha, Nebraska  68131-2197
Southwest Regional Cancer Center Austin, Texas  78705
Good Samaritan Medical Center West Palm Beach, Florida  33401
Louisiana Oncology Associates Lafayette, Louisiana  70506
WellStar Cobb Hospital Austell, Georgia  30106
Mercy Cancer Center Mason City, Iowa  50401
Ellis Fischel Cancer Center Columbia, Missouri  65203
Highlands Oncology Group Springdale, Arkansas  72764
Genesis Cancer Center Hot Springs, Arkansas  71913
Medical Oncology Care Associates Orange, California  92668
Hennepin County Medical Center Minneapolis, Minnesota  
Maine General Medical Center Waterville, Maine  04901
Advanced Oncology Associates Armonk, New York  10504
New Mexico Oncology Hematology Consultants Albuquerque, New Mexico  87102
Little Rock Hematology/Oncology Associates Little Rock, Arkansas  72205
Naval Medical Center San Diego, California  92134
Danbury Hospital/Praxair Cancer Center Danbury, Connecticut  06810
Washington VA Medical Center Washington, District of Columbia  20422
Walter Reed Army Hospital Washington, District of Columbia  20307
Joliet Oncology/Hematology Associates,Ltd. Joliet, Illinois  60435
Mid Illinois Hematology and Oncology Associates, Ltd. Normal, Illinois  61761
Community Cancer Care, Inc. Indianapolis, Indiana  46202
Associated Physicians & Surgeons Clinic, LLC Terre Haute, Indiana  47804
Siouxland Hematology/Oncology Associates Sioux City, Iowa  51101
Jewish Medical Plaza Louisville, Kentucky  40202
University of Louisville Louisville, Kentucky  40202
Louisiana State University Health Sciences Center Shreveport, Louisiana  71130
Hematology and Oncology Associates of Southern Michigan,P.C Jackson, Michigan  49201
Fairview-University Medical Center, University of Minnesota Minneapolis, Minnesota  55455
Metro Minnesota CCOP St. Louis Park, Minnesota  55416
The Center for Cancer and Hematologic Disease Cherry Hill, New Jersey  08003
Hematology-Oncology of Central New Jersey Red Bank, New Jersey  07701
Brooklyn VA Brooklyn, New York  11209
Clifton Springs Hospital and Clinic Clifton Springs, New York  14432
Goshen Medical Associates Goshen, New York  10924
New York Oncology-Hematology,P.C./Capital District Hematology, Oncology Associates Latham, New York  12110
Hematology/Oncology of Rockland New York, New York  
Upstate New York Cancer R & E Rochester, New York  14623
Raleigh Hematology Associates, Wake Practice Cary, North Carolina  27609
Quadrangle Medical Specialists, Southern Oncology Research Greenville, North Carolina  27834
Mid Dakota Clinic Bismarck, North Dakota  58501
Columbus CCOP Columbus, Ohio  43206
Central Pennsylvania Hematology & Medical Oncology Associates, P.C. Lemoyne, Pennsylvania  17043
Albert Einstein Healthcare Network Philadelphia, Pennsylvania  19141
University of Pittsburgh Medical Center/University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania  15213
Guthrie Clinic Ltd Sayre, Pennsylvania  18840
Boston Cancer Group, PLC Memphis, Tennessee  38104
Don & Sybil Harrington Cancer Center Amarillo, Texas  79106
Brackenridge Hospital Austin, Texas  78701
Southwest Cancer Center Lubbock, Texas  79415
Northwest Medical Specialties, PLLC Tacoma, Washington  98405