Inclusion Criteria:

- Histologic confirmation of non-small-cell lung cancer

- Stable systemic disease

- Maximum of one prior chemotherapy regimen for metastatic systemic disease

- Radiotherapy for local control or palliative bony lesions is allowed

- Karnofsky of greater than or equal to 70%

- Adequate hematologic, renal and liver function

Exclusion Criteria:

- Patients eligible for surgery of the brain

- Any previous chemotherapy for the brain metastasis

- Chemotherapy within 4 weeks or previous temozolomide

- Prior radiotherapy to the brain

- Radiation therapy to greater than 50% of the bone marrow

- Insufficient recovery from previous therapies

- Active nonmalignant systemic disease

- Inability to take oral medication

- Pregnant or nursing women

- Non use of adequate contraceptive techniques, negative urine pregnancy test is
required

- Known AIDS related illness