The UK Familial Ovarian Cancer Screening Study
- Determine an optimal screening procedure for ovarian cancer, in terms of the most
appropriate screening test, criteria for interpretation of results, and screening
intervals, in women at high genetic risk for developing ovarian cancer.
- Determine the physical morbidity and the resource implications associated with ovarian
cancer screening in these women.
- Assess the feasibility of screening this high-risk population in terms of compliance
OUTLINE: Patients undergo transvaginal ultrasonography of the ovaries (scheduled for the
early follicular phase, day 3-6 of the menstrual cycle) and CA 125 measurement annually.
Blood samples are collected every 4 months for analysis of CA 125 levels and novel markers.
Peer Reviewed and Funded or Endorsed by Cancer Research UK
PROJECTED ACCRUAL: A total of 5,000 patients will be accrued for this study.
Primary Purpose: Screening
James Mackay, MD, MA, FRCP, FRCPE
Institute of Child Health
United States: Federal Government