Radical Prostatectomy for Locally Advanced Prostate Cancer. A Feasibility Study
- Determine the success rate of radical prostatectomy in patients with locally advanced
adenocarcinoma of the prostate.
- Determine the serious toxic event rate of this surgery in these patients.
- Determine the pN status of patients treated with this surgery.
- Determine the percentage of patients found to have organ-confined tumors (pT2) after
undergoing this surgery.
- Determine the 2-year prostate-specific antigen-free survival rate of patients treated
with this surgery.
- Determine the surgical morbidity rates of patients treated with this surgery.
OUTLINE: This is a multicenter study.
Patients undergo limited pelvic lymphadenectomy and then radical retropubic prostatectomy.
Patients who are found to have pN-positive disease receive further treatment according to
the investigator's discretion. Patients with pN0 disease are followed every 3 months for 1
year and then every 4 months for 1 year.
PROJECTED ACCRUAL: A total of 32-74 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Treatment
Hein van Poppel, MD, PhD
United States: Federal Government