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Total Body Irradiation for Bone Marrow Transplants: Collaborative Efforts


Phase 2
N/A
N/A
Not Enrolling
Both
Neoplasm

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Trial Information

Total Body Irradiation for Bone Marrow Transplants: Collaborative Efforts


Most bone marrow transplantations for malignant and non-malignant disease include whole body
irradiation. Techniques for administering that treatment, including patient positioning,
lung and soft tissue compensation, dose rate, total dose and fractionation differ between
institutions. These differences are optimized at each institution to limit toxicity and
maximize therapeutic outcome.

Technically complex procedures such as total body radiation are subject to equipment
failures. Such failures mid-treatment could be catastrophic to the patient, since therapy
must be timely and compatible therapy may not be available elsewhere in the community. The
purpose of this protocol is to provide backup between George Washington University Medical
Center and the Radiation Oncology Branch of the NCI to allow for orderly, safe, and
compatible therapies in the event of equipment failure; or replacement of a linear
accelerator or any other malfunctioning equipment necessary to deliver TBI; or any emergent
situation.

Inclusion Criteria


INCLUSION CRITERIA:

Patients must sign informed consent.

Supporting institution physicians must agree that therapy is appropriate and safe.

Type of Study:

Interventional

Study Design:

Endpoint Classification: Safety/Efficacy Study, Primary Purpose: Treatment

Authority:

United States: Federal Government

Study ID:

950003

NCT ID:

NCT00026858

Start Date:

October 1994

Completion Date:

November 2002

Related Keywords:

  • Neoplasm
  • Bone Marrow Transplantation
  • Leukemia
  • Breast Cancer
  • Multiple Myeloma
  • Total Body Irradiation
  • Neoplasms

Name

Location

National Cancer Institute (NCI)Bethesda, Maryland  20892