Treatment of Children With Newly Diagnosed Diffuse Pontine Gliomas Using Conventional Radiotherapy and High Dose Tamoxifen
- Determine whether high-dose tamoxifen with radiotherapy increases the median survival
and overall survival of children with newly diagnosed brain stem gliomas.
- Determine the time to neurologic or radiographic progression in patients treated with
- Determine the acute and chronic toxicity of high-dose tamoxifen in these patients.
OUTLINE: This is a multicenter study.
Patients undergo radiotherapy once daily 5 days a week for 6 weeks. Within 2 weeks after the
initiation of radiotherapy, patients receive oral high-dose tamoxifen once daily. Tamoxifen
continues in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: Approximately 60 patients will be accrued for this study within 4 years.
Primary Purpose: Treatment
Anthony Michalski, MD
Great Ormond Street Hospital for Children NHS Foundation Trust
United States: Federal Government