A Randomized Trial of Radical Prostatectomy Versus Brachytherapy for Patients With T1c or T2a N0 M0 Prostate Cancer
- Compare overall survival in patients with stage II prostate cancer treated with radical
prostatectomy vs brachytherapy.
- Compare metastasis-free survival and probability of survival without symptoms of
patients treated with these regimens.
- Compare the side effects of these treatment regimens in these patients.
OUTLINE: This is a randomized study. Patients are randomized to one of two treatment arms.
- Arm I: Patients undergo radical prostatectomy.
- Arm II: Patients undergo brachytherapy with implanted iodine I 125 or palladium Pd 103
seeds Patients are followed every 6 months for 5 years and then annually thereafter.
PROJECTED ACCRUAL: A total of 1,980 patients (990 per treatment arm) will be accrued for
this study within 5.5 years.
Allocation: Randomized, Primary Purpose: Treatment
Paul H. Lange, MD
University of Washington
United States: Federal Government
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|
|University of Texas - MD Anderson Cancer Center||Houston, Texas 77030-4009|
|Walter Reed Army Medical Center||Washington, District of Columbia 20307-5000|
|H. Lee Moffitt Cancer Center and Research Institute||Tampa, Florida 33612|
|Washington University School of Medicine||Saint Louis, Missouri 63110|
|Beth Israel Deaconess Medical Center||Boston, Massachusetts 02215|
|Comprehensive Cancer Center at Wake Forest University||Winston-Salem, North Carolina 27157-1082|
|Dixie Regional Medical Center||Saint George, Utah 84770|
|LDS Hospital||Salt Lake City, Utah 84143|
|Holden Comprehensive Cancer Center at University of Iowa||Iowa City, Iowa 52242-1002|
|Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center||Nashville, Tennessee 37232-2516|
|Cleveland Clinic Taussig Cancer Center||Cleveland, Ohio 44195|
|Veterans Affairs Medical Center - Seattle||Seattle, Washington 98108|
|Madigan Army Medical Center||Tacoma, Washington 98431-5048|
|Utah Valley Regional Medical Center - Provo||Provo, Utah 84604|
|Veterans Affairs Medical Center - Richmond||Richmond, Virginia 23249|
|UCSF Comprehensive Cancer Center||San Francisco, California 94115|
|Southern Illinois University School of Medicine||Springfield, Illinois 62794-9658|
|Wilford Hall Medical Center||Lackland Air Force Base, Texas 78236-5300|
|Winship Cancer Institute of Emory University||Atlanta, Georgia 30322|
|Wellspan Health - York Cancer Center||York, Pennsylvania 17403|
|James P. Wilmot Cancer Center at University of Rochester Medical Center||Rochester, New York 14642|
|American Fork Hospital||American Fork, Utah 84003|
|McKay-Dee Hospital Center||Ogden, Utah 84403|
|University Cancer Center at University of Washington Medical Center||Seattle, Washington 98195|
|Fletcher Allen Health Care - Medical Center Campus||Burlington, Vermont 05401|
|Kansas Cancer Institute at the University of Kansas Medical Center||Kansas City, Kansas 66160-7357|
|Sentara Norfolk General Hospital||Norfolk, Virginia 23507|
|St. Vincent Cancer Center||Little Rock, Arkansas 72205-5499|
|Northeast Heights Cancer Center||Albuquerque, New Mexico 87109|