Gene Expression Analysis in Cutaneous T-Cell Lymphoma
- Identify gene expression patterns in malignant T cells that can be used to diagnose
cutaneous T-cell lymphoma.
- Determine the patterns of gene expression that distinguish normal skin-homing T cells
from malignant T cells.
OUTLINE: Patients are stratified by disease (Sezary syndrome vs mycosis fungoides) and prior
treatment (yes vs no).
All patients receive a physical examination, and a medical history is taken. Patients with
Sezary syndrome undergo leukapheresis. Patients with plaque/tumor stage mycosis fungoides
undergo skin biopsy of involved skin. Malignant T cells from blood or skin are then isolated
and patterns of gene expression in the malignant T cells are compared to those in normal
skin-homing T cells from healthy donors using a "gene chip" (Lymphochip).
Patients are followed annually for 5 years.
PROJECTED ACCRUAL: A total of 40 patients (20 per disease stratum) will be accrued for this
study within 2 years.
Primary Purpose: Diagnostic
Sam T. Hwang, MD, PhD
NCI - Dermatology Branch
United States: Federal Government
|Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support||Bethesda, Maryland 20892-1182|