Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed pancreatic, gastric, biliary system, or
hepatocellular carcinoma beyond the scope of surgical resection Gastrointestinal tract
carcinoid tumor or carcinoma of the small bowel allowed Bidimensionally measurable disease
Ineligible for ECOG 6296 (gastric cancer) No brain metastases, unless completely resected
and CT scan of the brain is normal

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-1 Life expectancy:
Not specified Hematopoietic: WBC at least 4,000/mm3 Platelet count at least 100,000/mm3
Hepatic: Bilirubin less than 3 times normal SGOT less than 3 times normal Renal:
Creatinine no greater than 2.0 mg/dL Cardiovascular: No New York Heart Association class
III or IV heart disease No chronic or uncontrolled angina No significant coronary artery
disease (even if asymptomatic) on cardiac catheterization or thallium stress test, in
patients with a history of atherosclerotic heart disease No congestive heart failure No
arrhythmia Pulmonary: No chronic obstructive pulmonary disease No chronic pulmonary
disease, including asthma, chronic bronchitis, emphysema, sarcoid, or bronchiectasis
Neurologic: No cerebellar disease No seizure disorder Other: HIV negative No active or
serious underlying infection No AIDS No psychiatric illness No organic mental syndrome No
major psychoaffective disorder No poorly controlled diabetes mellitus No serious
underlying illness that would preclude study No recent history of alcohol or drug abuse
Not pregnant or nursing Negative pregnancy test Fertile patients must use effective
contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent immunotherapy Chemotherapy: No
prior systemic chemotherapy for advanced disease Prior fluorouracil or gemcitabine as
radiosensitizer allowed No other prior chemotherapy Endocrine therapy: No concurrent
systemic steroids No concurrent hormonal therapy (excluding birth control pills) No
concurrent steroids as antiemetics or for chronic treatment Radiotherapy: At least 1 month
since prior radiotherapy Surgery: See Disease Characteristics Recovered from prior surgery
Other: At least 1 week since prior beta blockers No concurrent chronic treatment with
aspirin, non-steroidal anti-inflammatory drugs, antihistamines, antianginal medication,
extraordinary antihypertensive regimens, or antiarrhythmics (except cardiac glycosides)