Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed relapsed or refractory grade I, II, or III non-Hodgkin's
lymphoma (NHL), including follicular, small lymphocytic, or marginal zone/MALT
lymphoma

- Previously treated with radiotherapy, immunotherapy, and/or chemotherapy for NHL

- Progression of disease or no response since last treatment for NHL

- 1D10+ lymphoma by immunohistochemistry or flow cytometry

- Bidimensionally measurable disease at least 2 cm in a single dimension

- No CNS metastases

- Circulating tumor cells no greater than 5,000/mm^3

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- ECOG 0-2

Life expectancy:

- At least 3 months

Hematopoietic:

- Platelet count at least 75,000/mm^3 (unless disease related)

- Neutrophil count at least 1,000/mm^3 (unless disease related)

- Hemoglobin greater than 8.0 g/dL

Hepatic:

- Bilirubin less than 2.5 mg/dL

- SGOT less than 4 times upper limit of normal

Renal:

- Creatinine less than 2.5 mg/dL

Cardiovascular:

- No clinically significant cardiac disease (New York Heart Association class III or
IV)

- No evidence of myocardial infarction or cardiac arrhythmia (unless surgically
repaired) within the past 6 months

Pulmonary:

- No clinically significant pulmonary disease

Other:

- No other malignancy within the past 2 years except non-melanoma skin cancer or
carcinoma in situ

- No significant psychiatric or CNS impairment

- No active serious infection

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 1 month after study

- Negative anti-Hu1D10 antibody response (HAHA/HAMA)

- HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- See Disease Characteristics

- At least 4 weeks since prior interferon therapy

- At least 3 months since prior immunotherapy

- No prior monoclonal antibody Hu1D10

Chemotherapy:

- See Disease Characteristics

- At least 4 weeks since prior cytotoxic chemotherapy

Endocrine therapy:

- At least 4 weeks since prior corticosteroids (more than 10 mg prednisone/day)

- No concurrent corticosteroids at more than 10 mg prednisone/day for pre-existing
diseases or adverse reactions

Radiotherapy:

- See Disease Characteristics

- At least 4 weeks since prior external beam radiotherapy

- At least 3 months since prior radioimmunotherapy

Surgery:

- Not specified

Other:

- No other concurrent lymphoma therapy