Clinical Significance of Genetic Markers in Colon Cancer
- Determine the clinical and pathologic significance of unstable DNA elements in
colorectal cancer (tumor microsatellite instability).
- Determine the clinical and pathologic significance of loss of heterozygosity for
chromosomes 5, 8, 17, and 18 (as the primary targets) and of chromosomes 1, 14, and 22
(as the secondary targets) in colorectal cancer.
OUTLINE: DNA is examined for unstable elements (microsatellite instability and loss of
heterozygosity) by analyzing at least 10 separate (CA)n-repeats localized to 5 separate
chromosomes (5q, 8p, 15, 17p, and 18q). Loss of heterozygosity is analyzed for at least four
chromosomal arms (5q, 8p, 17p, and 18q) and later other chromosomes (e.g., 1, 14, and 22).
Immunohistochemistry is used to test for the presence or absence of the genes involved in
DNA mismatch repair (hMLH1 and hMSH2).
Patients do not receive the results of the genetic testing and the results do not influence
the type or duration of treatment.
PROJECTED ACCRUAL: This study will accrue up to 708 specimens.
Steven R. Alberts, MD
United States: Federal Government
|Mayo Clinic - Jacksonville||Jacksonville, Florida 32224|
|Mayo Clinic Cancer Center||Rochester, Minnesota 55905|
|CCOP - Mayo Clinic Scottsdale Oncology Program||Scottsdale, Arizona 85259|