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Treatment Decision Intervention for Veterans With Prostate Cancer

50 Years
80 Years
Not Enrolling
Prostate Cancer

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Trial Information

Treatment Decision Intervention for Veterans With Prostate Cancer


Newly diagnosed localized prostate cancer patients face difficult decisions about treatment
and management; including radiation therapy, radical prostatectomy, brachytherapy, and
observation. Previous studies have cited patient preference and physician recommendation
for treatment as major roles in treatment decisions.


This grant will be used to develop and evaluate a decision analysis based intervention to
improve decision-making among veterans with newly diagnosed localized prostate cancer.
While the ultimate goal of this study is to improve decision-making among these patients,
factors influencing physician recommendations for treatment will be sought. The former will
be achieved by evaluating the efficacy of providing physicians with information
incorporating patient preference for alternative health states with probabilities of
treatment outcomes. Factors influencing physician recommendations for treatment will be
determined through qualitative interviews with physicians.


Patients were accrued at the VA Chicago Health Care System Lakeside Urology Clinic. Upon
consent for participation in the study, comorbidities, histologic grade of the biopsy, and
age were obtained for 13 patients with newly diagnosed localized prostate cancer. Using a
standard gamble technique, interviewers obtained patient utilities for 5 distinct health
states related to prostate cancer treatment. Clinical and pathologic characteristics were
incorporated into the decision analytic model, and the derived quality-adjusted life
expectancies (QALEs) were shared with the treating urologist before patient-physician
discussion of treatment options. The feasibility of the decision analytic intervention and
unbiased estimates of the impact of the intervention was evaluated. The long-range
objective of this proposal is to design an intervention for veterans that increases
physician understanding of patient treatment preferences and patient understanding of
choices in prostate cancer treatment.



Inclusion Criteria:

1) biopsy confirmed diagnosis of localized prostate cancer; 2) newly diagnosed-no prior
treatment (including watchful waiting) or discussion with their prior physicians about
treatment options; 3) no previous neoplasms in the last five years, with the exception of
basal cell cancer of the skin; 4) speak english; 5) no major psychiatric disorder that
would preclude their participation; 6) be between 50 and 80 years of age.

Exclusion Criteria:

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Principal Investigator

Charles L. Bennett, MD PhD MPP

Investigator Role:

Principal Investigator

Investigator Affiliation:

Jesse Brown VAMC (WestSide Division)


United States: Federal Government

Study ID:

PCI 99-159



Start Date:

Completion Date:

December 2001

Related Keywords:

  • Prostate Cancer
  • Prostatic Neoplasms



Jesse Brown VAMC (WestSide Division) Chicago, Illinois  60612