PROTOCOL OUTLINE: Patients receive fludarabine IV over 2 hours on days -4 to -2 followed by
total body irradiation and peripheral blood stem cell or bone marrow transplantation on day
0. Patients also receive oral or IV cyclosporine 2-3 times daily on days -3 to 50 (related
donor) or 100 (unrelated donor) and oral mycophenolate mofetil twice daily on days 0 to 28
(related donor) or 40 (unrelated donor).
Patients may also receive donor lymphocyte infusion for continued treatment of symptoms in
the event of mixed chimerism and in the absence of graft-versus-host disease.
Patients are followed weekly for 1 month, monthly for 2 years, and then annually thereafter.
Primary Purpose: Treatment
Fred Hutchinson Cancer Research Center
|Fred Hutchinson Cancer Research Center||Seattle, Washington 98109|