Allogeneic Hematopoietic Stem Cell Transplantation for Induction of Mixed Hematopoietic Chimerism in Patients Infected With Human Immunodeficiency Virus-1 Using a Non-Marrow Ablative Conditioning Regimen Containing Total Body Irradiation in Combination With Post-Transplant Immunosuppression With Cyclosporine and Mycophenolate Mofetil
Patients receive oral or IV cyclosporine 2-3 times daily on Days -1 to 50. Patients undergo
total body irradiation followed by allogeneic peripheral blood stem cell or bone marrow
transplantation on Day 0 (assuming donor is available). Beginning within 6 hours of
transplantation, patients receive oral mycophenolate mofetil every 12 hours until Day 27.
Patients with an unstable level of chimerism may receive 1-2 donor lymphocyte infusions.
Patients are followed at Days 14, 28, 56, 80, 180, and 360.
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Mortality due to infection, donor chimerism
Days 14, 28, 56, 80, 180, and 360
Fred Hutchinson Cancer Research Center
United States: Federal Government
|Fred Hutchinson Cancer Research Center||Seattle, Washington 98109|