Study Of The Survival Without Degradation To The Quality Of Life During Chemotherapy For Metastatic Breast Cancer In Women
- Determine the survival without degradation of quality of life in elderly women with
metastatic breast cancer treated with leucovorin calcium, fluorouracil, and
- Determine the efficacy of this regimen, in terms of response and survival without
progression, in these patients.
- Determine the tolerance of these patients to this regimen.
OUTLINE: This is a multicenter study.
Patients receive mitoxantrone IV and leucovorin calcium IV over 2 hours on day 1. Patients
then receive fluorouracil IV over 46 hours on days 1-2. Treatment repeats every 21 days for
a maximum of 8 courses in the absence of disease progression or unacceptable toxicity.
Quality of life is assessed at baseline, after 3 courses, and at treatment completion.
Patients are followed every 3 months.
PROJECTED ACCRUAL: A total of 39 patients will be accrued for this study.
Primary Purpose: Treatment
Elisabeth Carola, MD
United States: Federal Government