Study Of Post-Operative Concomitant Radio-Chemotherapy With A Continuous Infusion Of Flourouracil For Adjuvant Treatment Of Resected Pancreatic Cancer
- Determine the tolerance of adjuvant fluorouracil with concurrent radiotherapy in
patients with resected pancreatic adenocarcinoma.
- Determine survival without local relapse in these patients treated with this regimen.
- Determine overall survival of these patients treated with this regimen.
- Determine the effectiveness of this adjuvant therapy in these patients.
OUTLINE: This is a multicenter study.
Patients receive high-dose radiotherapy 5 days a week for 5 weeks. Patients also receive
low-dose radiotherapy 4 times a week during the last 2 weeks of the 5-week course of
treatment. Patients concurrently receive fluorouracil IV continuously for 5 weeks in the
absence of disease progression or unacceptable toxicity.
Patients are followed for survival.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Primary Purpose: Treatment
Jacques Balosso, MD, PhD
CHU de Grenoble - Hopital de la Tronche
United States: Federal Government